Endocrine Disruption

Summary of the published study: Exposure to 17α-ethinylestradiol results in differential susceptibility of largemouth bass (Micropterus salmoides) to bacterial infection (Leet et al. in review)

Effects-directed analysis (EDA) reverse-engineers environmental toxicity testing by measuring effects on cells first, and identifying the particular chemicals later. In this publication, we reviewed published information on EDA methods to improve future methods.

Early development is a sensitive window for estrogenic endocrine disruption in largemouth bass. Atrazine treatments caused changes to gene expression patterns that were both similar to estrogen and distinct from estrogen.