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Changes in temperature and precipitation patterns under global climate change are expected to expand the range of suitable habitat for non-natives within stream networks, resulting in significant increases in the distribution and abundance of non-natives. However, our understanding of how landscape attributes can affect local thermal and hydrologic patterns suggests that changes in global climate patterns will not translate evenly across large spatial scales. Robust assessments of how the range of suitable habitat for non-natives will shift in response to climate change will require downscaled (that is, watershed and regional) climate predictions that integrate local landscape processes and niche models describing conditions suitable for non-native species. Ultimately, integrating these two components will allow managers to prioritize where and when to implement non-native control measures to minimize or eliminate non-native interactions under global climate change.