Potential evapotranspiration (PET), and reference evapotranspiration (ETo) are estimated at an approximately 1-kilometer spatial resolution and daily time-step from January 1, 2021 to December 31, 2021 for Florida, Alabama, Georgia, South Carolina, and parts of Mississippi, North Carolina, and Tennessee. PET and ETo were computed on the basis of solar radiation, meteorological data (min/max temperature, mean actual and saturation vapor pressure, and mean wind speed at 2-meter height), and shortwave blue-sky albedo data. Solar radiation was computed from Geostationary Operational Environmental Satellite (GOES) sensor data, blue-sky albedo was computed from the Moderate Resolution Imaging Spectrometer (MODIS) MCD43A1 BRDF/Albedo data product, and meteorological data were simulated using a high-resolution Weather Research and Forecasting (WRF) model. Actual and saturation vapor pressure are calculated from the WRF-simulated 2-meter air temperature ("T2") and water vapor mixing ratio ("Q2") output variables. PET and ETo estimates were bias corrected using evapotranspiration computed from meteorological data at 122 weather stations in Florida and Georgia. Open-source tools for managing the NetCDF files in this data release can be found at https://code.usgs.gov/jbellino/florida-goes-et.