We provide a comprehensive review of the status of non-native fishes in the central Indian River Lagoon (from Cape Canaveral to Grant-Valkaria, east of I-95) through literature review and field surveys. Historical records exist for 17 taxa (15 species, one hybrid, one species complex). We found historical records for one additional species and collected one species in our field survey that had never been recorded in the region before (and which we eradicated). Thus, we evaluate 19 total taxa herein. Of these, we document range expansion of four salt-tolerant cichlid species, extirpation of six species that were previously recorded from the area and eradication of three species. There was no noticeable change in geographic range for one widespread species and the records for one species are doubtful and may be erroneous. Currently, there is not enough information to evaluate geographic range for four species although at least one of these is established. We provide information on how non-native fishes may interact with or exacerbate phytoplankton blooms and resulting trophic cascades.