The USGS currently has MOUs, signed by the Director, with the following Federal agencies/entities:
- Academia
- Clean Beaches Council
- Council of Lake Committees
- Department of Agriculture
- Department of Commerce
- Department of Defense
- Department of Energy
- Department of Health and Human Services
- Department of Homeland Security
- Department of State
- Department of the Interior
- Environmental Protection Agency
- Association of American State Geologists
- United States Agency for International Development (USAID)
- USGS-IGBST and the Eastern Shoshone and Northern Arapaho Tribes
- Multi-Agency and Others As Necessary
- National Aeronautics and Space Administration
- National Archives and Records Administration
- National Association of State Universities and Land-Grant Colleges
- National Hispanic Environmental Council
- National Science Foundation
- Nuclear Regulatory Commission
- Reston Association
- Smithsonian Tropical Research Institute
- Southwest Consortium for Environmental Research and Policy (SCERP)
- The Weather Company, LLC
- The Wildlife Society
- U.S. Geological Survey and Yukon River Inter-Tribal Watershed Council
- United States International Boundary and Water Commission
- Department of Transportation