Data were collected in the White River and its tributaries in and near Indianapolis, Indiana, on the diversity and density of benthic invertebrates; concentrations of metals, insecticides, herbicides, and semivolatile organic compounds sorbed on streambed sediments; and particle-size distribution of streambed sediments. A total of 369 benthic-invertebrate samples were collected at 21 sites during late spring or summer and early fall 1994 through 1996; of these, 30 were quality-control samples. A total of 33 streambed-sediment samples were collected at 14 sites during August 1994, 1995, and 1996; of these, 10 were quality-control samples.