Knowledge of the factors affecting the vigor of desert riparian trees is important for their conservation and management. I used multiple regression to assess effects of streamflow and climate (12–14 years of data) or climate alone (up to 60 years of data) on radial growth of clonal narrowleaf cottonwood (Populus angustifolia), a foundation species in the arid, Closed Basin portion of the San Luis Valley, Colorado. I collected increment cores from trees (14–90 cm DBH) at four sites along each of Sand and Deadman creeks (total N = 85), including both perennial and ephemeral reaches. Analyses on trees