Skip to main content
U.S. flag

An official website of the United States government

Expressed MHC class II genes in sea otters (Enhydra lutris) from geographically disparate populations

January 1, 2006

The major histocompatibility complex (MHC) is central to maintaining the immunologic vigor of individuals and populations. Classical MHC class II genes were targeted for partial sequencing in sea otters (Enhydra lutris) from populations in California, Washington, and Alaska. Sequences derived from sea otter peripheral blood leukocyte mRNAs were similar to those classified as DQA, DQB, DRA, and DRB in other species. Comparisons of the derived amino acid compositions supported the classification of these as functional molecules from at least one DQA, DQB, and DRA locus and at least two DRB loci. While limited in scope, phylogenetic analysis of the DRB peptide‐binding region suggested the possible existence of distinct clades demarcated by geographic region. These preliminary findings support the need for additional MHC gene sequencing and expansion to a comprehensive study targeting additional otters.

Citation Information

Publication Year 2006
Title Expressed MHC class II genes in sea otters (Enhydra lutris) from geographically disparate populations
DOI 10.1111/j.1399-0039.2006.00559.x
Authors Lizabeth Bowen, B.M. Aldridge, A. Keith Miles, J.L. Stott
Publication Type Article
Publication Subtype Journal Article
Series Title Tissue Antigens
Series Number
Index ID 70030486
Record Source USGS Publications Warehouse
USGS Organization Western Ecological Research Center