Lizabeth Bowen
Biography
My research program focuses on the interactions among immunology, toxicology, disease ecology, and ecosystem health. I analyze the physiologic and metabolic effects of stressors on organisms and how subsequent vulnerabilities translate into population and ecosystem health. Stressors can be either chemical (pesticides, petroleum hydrocarbons), physical (e.g., elevated water temperature), or biological (toxins, pathogens). My long-term goal is to better understand the effects of anthropogenic and natural stressors on individuals and how those stressors are reflected in an individual organism’s fitness (survival and reproduction), the population level effects of differential survival and reproduction of individuals, and the ecosystem level effects of population change.
RESEARCH INTERESTS
- Eco-immunology
- Nearshore marine ecosystem health
- Conservation biology
- Eco-toxicology
- Individual and population level susceptibility
EDUCATION
Ph.D., Ecology, University of California, Davis. 2003.
- Thesis: Immunogenetics in the California sea lion (Zalophus californianus): evolution of the major histocompatibility complex under differential ecological pressures
Master of Science, Ecology, University of California, Davis. 1995.
- Thesis: Defenses of insular endemic plants in the absence of herbivory
Bachelor of Arts, Biology. University of California, Santa Cruz. 1989.
PROFESSIONAL EXPERIENCE
- Ecologist, U. S. Geological Survey, 2004–present
- Assistant Project Scientist, UC Davis, 2005– 2009
- Postdoctoral Fellow, UC Davis, 2003-2004
- Post Graduate Researcher, UC Davis. 1998-2003
- Post Graduate Researcher, UC Davis, 1998
- Research Assistant, UC Davis, 1996
- Teaching Assistant, UC Davis, 1994-1996
Science and Products
Assessing heat stress in migrating Yukon River Chinook Salmon
We will examine evidence of heat stress in Yukon River Chinook salmon (Oncorhynchus tshawytscha) using heat shock proteins and gene expression.
Polar Bear Health and Disease Diagnostics
In 2012, scientists noticed that nearly a third of polar bears sampled in a study in Alaska were suffering from hair loss and poor health. Drs. Lizabeth Bowen and A. Keith Miles of WERC used new technology to track down and identify the factors responsible for driving disease in Alaskan polar bears.
Developing Physiological Diagnostics for the Desert Tortoise
The Mojave desert tortoise is listed as “threatened” under the Endangered Species Act and faces threats from habitat loss, predators, and disease. Drs. Lizabeth Bowen and A. Keith Miles with WERC are designing new methods to determine the type and influence of stressors present in the environment for the tortoise and other wildlife.
Environmental Stressors and Wildlife Health
Environmental stressors such as contaminants and disease can cause physiological imbalance in all types of wildlife. WERC’s Drs. Lizabeth Bowen and A. Keith Miles develop gene transcription profiles to detect organisms’ physiological responses to environmental stressors and provide resource managers with early warnings for potential effects on wildlife and ecosystem health.
Davis Field Station
The Davis Field Station is home to research programs that focus on coastal ecosystem dynamics, ecological stressors, and their effects on wildlife populations. These studies primarily take place along the Pacific coast from the Aleutian Islands to southern California. Current projects investigate sea-level rise along both coasts of North America, landscape-scale aquatic and terrestrial ecology...
Translocations maintain genetic diversity and increase connectivity in sea otters, Enhydra lutris
Sea otters, Enhydra lutris, were once abundant along the nearshore areas of the North Pacific. The international maritime fur trade that ended in 1911 left 13 small remnant populations with low genetic diversity. Subsequent translocations into previously occupied habitat resulted in several reintroduced populations along the coast of North...
Larson, Shawn E.; Gagne, Roderick B.; Bodkin, James L.; Murray, Michael J.; Ralls, Katherine; Bowen, Lizabeth; Leblois, Raphael; Piry, Sylvain; Penedo, Maria Cecilia; Tinker, M. Tim; Ernest, Holly B. Sea otter population collapse in southwest Alaska: Assessing ecological covariates, consequences, and causal factors
Sea otter (Enhydra lutris) populations in southwest Alaska declined substantially between about 1990 and the most recent set of surveys in 2015. Here we report changes in the distribution and abundance of sea otters, and covarying patterns in reproduction, mortality, body size and condition, diet and foraging behavior, food availability, health...
Tinker, M Tim; Bodkin, James L; Bowen, Lizabeth; Ballachey, Brenda; Bentall, Gena; Burdin, Alexander; Coletti, Heather; Esslinger, George G.; Hatfield, Brian; Kenner, Michael C.; Kloecker, Kimberly A.; Konar, Brenda; Miles, A. Keith; Monson, Daniel; Murray, Michael J.; Weitzman, Ben; Estes, James A A manipulative thermal challenge protocol for adult salmonids in remote field settings
Manipulative experiments provide stronger evidence for identifying cause-and-effect relationships than correlative studies, but protocols for implementing temperature manipulations are lacking for large species in remote settings. We developed an experimental protocol for holding adult Chinook salmon (Oncorhynchus tshawytscha) and exposing them to...
Donnelly, Daniel S.; von Biela, Vanessa R.; McCormick, Stephen D.; Laske, Sarah M.; Carey, Michael P.; Waters, Shannon C.; Bowen, Lizabeth; Brown, Randy J; Larson, Sean; Zimmerman, Christian E. Transcriptomic response to elevated water temperatures in adult migrating Yukon River Chinook salmon (Oncorhynchus tshawytscha)
Chinook salmon (Oncorhynchus tshawytscha) declines are widespread and may be attributed, at least in part, to warming river temperatures. Water temperatures in the Yukon River and tributaries often exceed 18°C, a threshold commonly associated with heat stress and elevated mortality in Pacific salmon. Untangling the complex web of direct and...
Bowen, Lizabeth; von Biela, Vanessa R.; McCormick, Stephen D.; Regish, Amy M.; Waters, Shannon C.; Durbin-Johnson, Blythe; Britton, Monica; Settles, Matt; Donnelly, Daniel S.; Laske, Sarah M.; Carey, Michael P.; Brown, Randy J; Zimmerman, Christian E. Evidence of prevalent heat stress in Yukon River Chinook salmon
Migrating adult Pacific salmon (Oncorhynchus spp.) are sensitive to warm water (>18 °C), with a range of consequences from decreased spawning success to early mortality. We examined the proportion of Yukon River Chinook salmon (O. tshawytscha) exhibiting evidence of heat stress to assess the potential that high temperatures contribute to...
von Biela, Vanessa R.; Bowen, Lizabeth; McCormick, Stephen D.; Carey, Michael P.; Donnelly, Daniel S.; Waters, Shannon C.; Regish, Amy M.; Laske, Sarah M.; Brown, Randy J; Larson, Sean; Zuray, Stan; Zimmerman, Christian E. Gene transcript profiling in desert bighorn sheep
Respiratory disease is a key factor affecting the conservation and recovery of bighorn sheep (Ovis canadensis ) populations. Innovative, minimally invasive tools such as gene transcription–based diagnostics have the potential to improve our understanding of the broad range of factors that can affect the health of wild sheep. Evaluation of...
Bowen, Lizabeth; Longshore, Kathleen; Wolff, Peregrine; Klinger, Robert C.; Cox, Mike; Bullock, Sarah; Waters, Shannon C.; Miles, A. Keith Monitoring nearshore ecosystem health using Pacific razor clams (Siliqua patula) as an indicator species
An emerging approach to ecosystem monitoring involves the use of physiological biomarker analyses in combination with gene transcription assays. For the first time, we employed these tools to evaluate the Pacific razor clam (Siliqua patula), which is important both economically and ecologically, as a bioindicator species in the northeast Pacific....
Bowen, Lizabeth; Counihan, Katrina; Ballachey, Brenda E.; Colletti, Heather A; Hollmen, Tuula E.; Pister, Benjamin; Wilson, Tammy L Physiological and gene transcription assays to assess responses of mussels to environmental changes
Coastal regions worldwide face increasing management concerns due to natural and anthropogenic forces that have the potential to significantly degrade nearshore marine resources. The goal of our study was to develop and test a monitoring strategy for nearshore marine ecosystems in remote areas that are not readily accessible for sampling. Mussel...
Counihan, Katrina; Bowen, Lizabeth; Ballachey, Brenda; Coletti, Heather A.; Hollman, Tuula; Pister, Benjamin; Wilson, Tammy L
Southern sea otter (Enhydra lutris nereis) population biology at Big Sur and Monterey, California --Investigating the consequences of resource abundance and anthropogenic stressors for sea otter recovery
The range of the southern sea otter (Enhydra lutris nereis) spans most of the central California coast from Half Moon Bay to Gaviota. Some coastal areas within this range are heavily developed and highly impacted by humans, while other areas are wild and largely pristine. Determining the relative importance of food resource abundance,...
Tinker, M. Tim; Tomoleoni, Joseph A.; Weitzman, Benjamin P.; Staedler, Michelle; Jessup, Dave; Murray, Michael J.; Miller, Melissa; Burgess, Tristan; Bowen, Lizabeth; Miles, A. Keith; Thometz, Nicole; Tarjan, Lily; Golson, Emily; Batac, Francesca; Dodd, Erin; Berberich, Eva; Kunz, Jessica; Bentall, Gena; Fujii, Jessica; Nicholson, Teri; Newsome, Seth; Melli, Ann; LaRoche, Nicole; MacCormick, Holly; Johnson, Andy; Henkel, Laird; Kreuder-Johnson, Chris; Conrad, Pat Complex immune responses and molecular reactions to pathogens and disease in a desert reptile (Gopherus agassizii)
Immune function plays an important role in an animal's defense against infectious disease. In reptiles, immune responses may be complex and counterintuitive, and diagnostic tools used to identify infection, such as induced antibody responses are limited. Recent studies using gene transcription profiling in tortoises have proven useful in...
Drake, K. Kristina; Aiello, Christina M.; Bowen, Lizabeth; Lewison, Rebecca L.; Esque, Todd C.; Nussear, Kenneth E.; Waters, Shannon C.; Hudson, Peter J. Using gene transcription to assess ecological and anthropological stressors in brown bears
Increasingly, population- and ecosystem-level health assessments are performed using sophisticated molecular tools. Advances in molecular technology enable the identification of synergistic effects of multiple stressors on the individual physiology of different species. Brown bears (Ursus arctos) are an apex predator; thus, they are ideal...
Bowen, Lizabeth; Miles, A. Keith; Waters, Shannon C.; Gustine, Dave; Joly, Kyle; Hilderbrand, Grant V. MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans
We examined the associations between California sea lion MHC class II DRB (Zaca-DRB) configuration and diversity, and leptospirosis. As Zaca-DRB gene sequences are involved with antigen presentation of bacteria and other extracellular pathogens, we predicted that they would play a role in determining responses to these pathogenic spirochaetes....
Acevedo-Whitehouse, Karina; Gulland, Frances; Bowen, Lizabeth