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Lyme disease ecology in a changing world: Consensus, uncertainty and critical gaps for improving control

April 24, 2017

Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi. Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host–vector-borne zoonotic disease.

Publication Year 2017
Title Lyme disease ecology in a changing world: Consensus, uncertainty and critical gaps for improving control
DOI 10.1098/rstb.2016.0117
Authors A. Marm Kilpatrick, Andrew D.M. Dobson, Taal Levi, Daniel J. Salkeld, Andrea Swei, Howard S. Ginsberg, Anne Kjemtrup, Kerry A. Padgett, Per A. Jensen, Durland Fish, Nick H. Ogden, Maria A. Diuk-Wasser
Publication Type Article
Publication Subtype Journal Article
Series Title Philosophical Transactions of the Royal Society B: Biological Sciences
Index ID 70187122
Record Source USGS Publications Warehouse
USGS Organization Patuxent Wildlife Research Center