Witchweed [(Striga asiatica (L.) O. Kuntze)] is a parasitic weed from Asia and Africa that attaches to the roots of grasses and grass crops such as corn and sorghum. Witchweed was first detected in the western hemisphere in a corn field in Columbus County, North Carolina, in July, 1956. Since that time, a federal/state cooperative program has eliminated over 99% of the 432,000+ acres that have been found infested with witchweed in the eastern Carolinas. This chapter provides an overview of the USDA-Carolinas Witchweed Eradication Program, as well as the methods and procedures that have been employed to achieve this remarkable level of success.