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Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents

July 1, 2010

Facilities involved in the manufacture of pharmaceutical products are an under-investigated source of pharmaceuticals to the environment. Between 2004 and 2009, 35 to 38 effluent samples were collected from each of three wastewater treatment plants (WWTPs) in New York and analyzed for seven pharmaceuticals including opioids and muscle relaxants. Two WWTPs (NY2 and NY3) receive substantial flows (>20% of plant flow) from pharmaceutical formulation facilities (PFF) and one (NY1) receives no PFF flow. Samples of effluents from 23 WWTPs across the United States were analyzed once for these pharmaceuticals as part of a national survey. Maximum pharmaceutical effluent concentrations for the national survey and NY1 effluent samples were generally <1 microg/L. Four pharmaceuticals (methadone, oxycodone, butalbital, and metaxalone) in samples of NY3 effluent had median concentrations ranging from 3.4 to >400 microg/L. Maximum concentrations of oxycodone (1700 microg/L) and metaxalone (3800 microg/L) in samples from NY3 effluent exceeded 1000 microg/L. Three pharmaceuticals (butalbital, carisoprodol, and oxycodone) in samples of NY2 effluent had median concentrations ranging from 2 to 11 microg/L. These findings suggest that current manufacturing practices at these PFFs can result in pharmaceuticals concentrations from 10 to 1000 times higher than those typically found in WWTP effluents.

Publication Year 2010
Title Pharmaceutical formulation facilities as sources of opioids and other pharmaceuticals to wastewater treatment plant effluents
DOI 10.1021/es100356f
Authors Patrick J. Phillips, Steven G. Smith, Dana W. Kolpin, Brooke W. Stinson, Steven D. Zaugg, Herbert T. Buxton, Edward T. Furlong, Kathleen Esposito
Publication Type Article
Publication Subtype Journal Article
Series Title Environmental Science & Technology
Index ID 70200010
Record Source USGS Publications Warehouse
USGS Organization National Water Quality Laboratory; Toxic Substances Hydrology Program
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