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Use of Rhodamine B as a biomarker for oral plague vaccination of prairie dogs

January 22, 2012

Oral vaccination against Yersinia pestis could provide a feasible approach for controlling plague in prairie dogs (Cynomys spp.) for conservation and public health purposes. Biomarkers are useful in wildlife vaccination programs to demonstrate exposure to vaccine baits. Rhodamine B (RB) was tested as a potential biomarker for oral plague vaccination because it allows nonlethal sampling of animals through hair, blood, and feces. We found that RB is an appropriate marker for bait uptake studies of C. ludovicianus) when used at concentrations <0.5% of bait mass dosed to deliver >10 mg RB per kg target animal mass. Whiskers with follicles provided the best sample for RB detection.

Citation Information

Publication Year 2011
Title Use of Rhodamine B as a biomarker for oral plague vaccination of prairie dogs
DOI 10.7589/0090-3558-47.3.765
Authors Julia Rodriguez-Ramos Fernandez, Tonie E. Rocke
Publication Type Article
Publication Subtype Journal Article
Series Title Journal of Wildlife Diseases
Series Number
Index ID 70005592
Record Source USGS Publications Warehouse
USGS Organization National Wildlife Health Center

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