Water resources data for the 2000 water year for South Carolina consist of records of stage, discharge, and water quality of streams; stage and contents of lakes and reservoirs; and ground-water levels. This report contains discharge records for 120 gaging stations; stage-only records for 39 gaging stations; stage and contents for 15 lakes and reservoirs; water quality for 38 gaging stations; and water levels for 46 observation wells. Also included are data for 52 crest-stage partial-record stations and discharge measurements at 7 miscellaneous sites. Additional water data were collected at various sites, not part of the systematic data collection program, and are published as miscellaneous investigations of water quality. These data represent that part of the National Water Data System collected by the U.S. Geological Survey and cooperating State and Federal agencies in South Carolina.