Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
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Laboratory investigations of African Pouched Rats (Cricetomys gambianus) as a potential reservoir host species for Monkeypox Virus Laboratory investigations of African Pouched Rats (Cricetomys gambianus) as a potential reservoir host species for Monkeypox Virus
Monkeypox is a zoonotic disease endemic to central and western Africa, where it is a major public health concern. Although Monkeypox virus (MPXV) and monkeypox disease in humans have been well characterized, little is known about its natural history, or its maintenance in animal populations of sylvatic reservoir(s). In 2003, several species of rodents imported from Ghana were involved in...
Authors
Christina L. Hutson, Yoshinori J. Nakazawa, Joshua Self, Victoria A. Olson, Russell L. Regnery, Zachary Braden, Sonja Weiss, Jean Malekani, Eddie Jackson, Mallory Tate, Kevin L. Karem, Tonie E. Rocke, Jorge E. Osorio, Inger K. Damon, Darin S. Carroll
Apparent field safety of a raccoon poxvirus-vectored plague vaccine in free-ranging prairie dogs (Cynomys spp.), Colorado, USA Apparent field safety of a raccoon poxvirus-vectored plague vaccine in free-ranging prairie dogs (Cynomys spp.), Colorado, USA
Prairie dogs (Cynomys spp.) suffer high rates of mortality from plague. An oral sylvatic plague vaccine using the raccoon poxvirus vector (designated RCN-F1/V307) has been developed for prairie dogs. This vaccine is incorporated into palatable bait along with rhodamine B as a biomarker. We conducted trials in August and September 2012 to demonstrate uptake and apparent safety of the RCN...
Authors
Daniel W. Tripp, Tonie E. Rocke, Sean P. Streich, Rachel C. Abbott, Jorge E. Osorio, Michael W. Miller
Age at vaccination may influence response to sylvatic plague vaccine (SPV) in Gunnison’s prairie dogs (Cynomys gunnisoni) Age at vaccination may influence response to sylvatic plague vaccine (SPV) in Gunnison’s prairie dogs (Cynomys gunnisoni)
Gunnison’s prairie dogs (Cynomys gunnisoni) have been considered at greater risk from Yersinia pestis (plague) infection in the montane portion of their range compared to populations at lower elevations, possibly due to factors related to flea transmission of the bacteria or greater host susceptibility. To test the latter hypothesis and determine whether vaccination against plague with...
Authors
Tonie E. Rocke, Daniel W. Tripp, Faye Lorenzsonn, Elizabeth A. Falendysz, Susan Smith, Judy L. Williamson, Rachel C. Abbott
Attenuation of monkeypox virus by deletion of genomic regions Attenuation of monkeypox virus by deletion of genomic regions
Monkeypox virus (MPXV) is an emerging pathogen from Africa that causes disease similar to smallpox. Two clades with different geographic distributions and virulence have been described. Here, we utilized bioinformatic tools to identify genomic regions in MPXV containing multiple virulence genes and explored their roles in pathogenicity; two selected regions were then deleted singularly...
Authors
Juan G. Lopera, Elizabeth A. Falendysz, Tonie E. Rocke, Jorge E. Osorio
Clostridium botulinum Clostridium botulinum
No abstract available.
Authors
Tonie E. Rocke, Rachel C. Abbott
Evaluation of monkeypox virus infection of prairie dogs (Cynomys ludovicianus) using in vivo bioluminescent imaging Evaluation of monkeypox virus infection of prairie dogs (Cynomys ludovicianus) using in vivo bioluminescent imaging
Monkeypox (MPX) is a re-emerging zoonotic disease that is endemic in Central and West Africa, where it can cause a smallpox-like disease in humans. Despite many epidemiologic and field investigations of MPX, no definitive reservoir species has been identified. Using recombinant viruses expressing the firefly luciferase (luc) gene, we previously demonstrated the suitability of in vivo
Authors
Elizabeth A. Falendysz, Angela M. Londono-Navas, Carol U. Meteyer, Nicola Pussini, Juan G. Lopera, Jorge E. Osorio, Tonie E. Rocke
Science and Products
Filter Total Items: 16
No Result Found
Filter Total Items: 134
Laboratory investigations of African Pouched Rats (Cricetomys gambianus) as a potential reservoir host species for Monkeypox Virus Laboratory investigations of African Pouched Rats (Cricetomys gambianus) as a potential reservoir host species for Monkeypox Virus
Monkeypox is a zoonotic disease endemic to central and western Africa, where it is a major public health concern. Although Monkeypox virus (MPXV) and monkeypox disease in humans have been well characterized, little is known about its natural history, or its maintenance in animal populations of sylvatic reservoir(s). In 2003, several species of rodents imported from Ghana were involved in...
Authors
Christina L. Hutson, Yoshinori J. Nakazawa, Joshua Self, Victoria A. Olson, Russell L. Regnery, Zachary Braden, Sonja Weiss, Jean Malekani, Eddie Jackson, Mallory Tate, Kevin L. Karem, Tonie E. Rocke, Jorge E. Osorio, Inger K. Damon, Darin S. Carroll
Apparent field safety of a raccoon poxvirus-vectored plague vaccine in free-ranging prairie dogs (Cynomys spp.), Colorado, USA Apparent field safety of a raccoon poxvirus-vectored plague vaccine in free-ranging prairie dogs (Cynomys spp.), Colorado, USA
Prairie dogs (Cynomys spp.) suffer high rates of mortality from plague. An oral sylvatic plague vaccine using the raccoon poxvirus vector (designated RCN-F1/V307) has been developed for prairie dogs. This vaccine is incorporated into palatable bait along with rhodamine B as a biomarker. We conducted trials in August and September 2012 to demonstrate uptake and apparent safety of the RCN...
Authors
Daniel W. Tripp, Tonie E. Rocke, Sean P. Streich, Rachel C. Abbott, Jorge E. Osorio, Michael W. Miller
Age at vaccination may influence response to sylvatic plague vaccine (SPV) in Gunnison’s prairie dogs (Cynomys gunnisoni) Age at vaccination may influence response to sylvatic plague vaccine (SPV) in Gunnison’s prairie dogs (Cynomys gunnisoni)
Gunnison’s prairie dogs (Cynomys gunnisoni) have been considered at greater risk from Yersinia pestis (plague) infection in the montane portion of their range compared to populations at lower elevations, possibly due to factors related to flea transmission of the bacteria or greater host susceptibility. To test the latter hypothesis and determine whether vaccination against plague with...
Authors
Tonie E. Rocke, Daniel W. Tripp, Faye Lorenzsonn, Elizabeth A. Falendysz, Susan Smith, Judy L. Williamson, Rachel C. Abbott
Attenuation of monkeypox virus by deletion of genomic regions Attenuation of monkeypox virus by deletion of genomic regions
Monkeypox virus (MPXV) is an emerging pathogen from Africa that causes disease similar to smallpox. Two clades with different geographic distributions and virulence have been described. Here, we utilized bioinformatic tools to identify genomic regions in MPXV containing multiple virulence genes and explored their roles in pathogenicity; two selected regions were then deleted singularly...
Authors
Juan G. Lopera, Elizabeth A. Falendysz, Tonie E. Rocke, Jorge E. Osorio
Clostridium botulinum Clostridium botulinum
No abstract available.
Authors
Tonie E. Rocke, Rachel C. Abbott
Evaluation of monkeypox virus infection of prairie dogs (Cynomys ludovicianus) using in vivo bioluminescent imaging Evaluation of monkeypox virus infection of prairie dogs (Cynomys ludovicianus) using in vivo bioluminescent imaging
Monkeypox (MPX) is a re-emerging zoonotic disease that is endemic in Central and West Africa, where it can cause a smallpox-like disease in humans. Despite many epidemiologic and field investigations of MPX, no definitive reservoir species has been identified. Using recombinant viruses expressing the firefly luciferase (luc) gene, we previously demonstrated the suitability of in vivo
Authors
Elizabeth A. Falendysz, Angela M. Londono-Navas, Carol U. Meteyer, Nicola Pussini, Juan G. Lopera, Jorge E. Osorio, Tonie E. Rocke