Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
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Managing prairie dogs by managing plague: a vaccine for the future? Managing prairie dogs by managing plague: a vaccine for the future?
The Black-footed Ferret Recovery Implementation Team Executive Committee is conducting a project to develop, and (hopefully) eventually implement, a plague vaccination program for prairie dogs. The project is a component of the Western Association of Fish and Wildlife Agencies Grasslands Conservation Initiative. An effective, field-worthy vaccine against plague could be the biggest...
Authors
Terry B. Johnson, Tonie E. Rocke, Pete Gober, Bill E. Van Pelt, Michael W. Miller, Daniel W. Tripp, Rachel C. Abbott, David L. Bergman
Season and application rates affect vaccine bait consumption by prairie dogs in Colorado and Utah, USA Season and application rates affect vaccine bait consumption by prairie dogs in Colorado and Utah, USA
Plague, a zoonotic disease caused by the bacterium Yersinia pestis, causes high rates of mortality in prairie dogs (Cynomys spp.). An oral vaccine against plague has been developed for prairie dogs along with a palatable bait to deliver vaccine and a biomarker to track bait consumption. We conducted field trials between September 2009 and September 2012 to develop recommendations for...
Authors
Daniel W. Tripp, Tonie E. Rocke, Sean P. Streich, Nathanael L. Brown, Julia Rodriguez-Ramos Fernandez, Michael W. Miller
A rapid field test for sylvatic plague exposure in wild animals A rapid field test for sylvatic plague exposure in wild animals
Plague surveillance is routinely conducted to predict future epizootics in wildlife and exposure risk for humans. The most common surveillance method for sylvatic plague is detection of antibodies to Yersinia pestis F1 capsular antigen in sentinel animals, such as coyotes (Canis latrans). Current serologic tests for Y. pestis, hemagglutination (HA) test and enzyme-linked immunosorbent...
Authors
Rachel C. Abbott, Robert Hudak, Roy Mondesire, Laurie A. Baeten, Robin E. Russell, Tonie E. Rocke
A recombinant raccoon poxvirus vaccine expressing both Yersinia pestis F1 and truncated V antigens protects animals against lethal plague. A recombinant raccoon poxvirus vaccine expressing both Yersinia pestis F1 and truncated V antigens protects animals against lethal plague.
In previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rRCN) expressing Yersinia pestis antigens (F1 and V307-a truncated version of the V protein) provided superior protection against plague challenge compared to individual single antigen constructs. To reduce costs of vaccine production and facilitate...
Authors
Tonie E. Rocke, B Kingstad-Bakke, W Berlier, J.E. Osorio
The innate immune response may be important for surviving plague in wild Gunnison's prairie dogs The innate immune response may be important for surviving plague in wild Gunnison's prairie dogs
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis, with ≥99% mortality reported from multiple studies of plague epizootics. A colony of Gunnison's prairie dogs (Cynomys gunnisoni) in the Aubrey Valley (AV) of northern Arizona appears to have survived several regional epizootics of plague, whereas nearby colonies have been severely affected by Y. pestis. To examine...
Authors
Joseph D. Busch, Roger Van Andel, Nathan E. Stone, Kacy R. Cobble, Roxanne Nottingham, Judy Lee, Michael VerSteeg, Jeff Corcoran, Jennifer Cordova, William E. Van Pelt, Megan M. Shuey, Jeffrey T. Foster, James M. Schupp, Stephen Beckstrom-Sternberg, James Beckstrom-Sternberg, Paul Keim, Susan Smith, Julia Rodriguez-Ramos, Judy L. Williamson, Tonie E. Rocke, David M. Wagner
Mapping monkeypox transmission risk through time and space in the Congo Basin Mapping monkeypox transmission risk through time and space in the Congo Basin
Monkeypox is a major public health concern in the Congo Basin area, with changing patterns of human case occurrences reported in recent years. Whether this trend results from better surveillance and detection methods, reduced proportions of vaccinated vs. non-vaccinated human populations, or changing environmental conditions remains unclear. Our objective is to examine potential...
Authors
Yoshinori J. Nakazawa, R. Ryan Lash, Darin S. Carroll, Inger K. Damon, Kevin L. Karem, Mary G. Reynolds, Jorge E. Osorio, Tonie E. Rocke, Jean Malekani, Jean-Jacques Muyembe, Pierre Formenty, A. Townsend Peterson
Science and Products
Filter Total Items: 16
No Result Found
Filter Total Items: 134
Managing prairie dogs by managing plague: a vaccine for the future? Managing prairie dogs by managing plague: a vaccine for the future?
The Black-footed Ferret Recovery Implementation Team Executive Committee is conducting a project to develop, and (hopefully) eventually implement, a plague vaccination program for prairie dogs. The project is a component of the Western Association of Fish and Wildlife Agencies Grasslands Conservation Initiative. An effective, field-worthy vaccine against plague could be the biggest...
Authors
Terry B. Johnson, Tonie E. Rocke, Pete Gober, Bill E. Van Pelt, Michael W. Miller, Daniel W. Tripp, Rachel C. Abbott, David L. Bergman
Season and application rates affect vaccine bait consumption by prairie dogs in Colorado and Utah, USA Season and application rates affect vaccine bait consumption by prairie dogs in Colorado and Utah, USA
Plague, a zoonotic disease caused by the bacterium Yersinia pestis, causes high rates of mortality in prairie dogs (Cynomys spp.). An oral vaccine against plague has been developed for prairie dogs along with a palatable bait to deliver vaccine and a biomarker to track bait consumption. We conducted field trials between September 2009 and September 2012 to develop recommendations for...
Authors
Daniel W. Tripp, Tonie E. Rocke, Sean P. Streich, Nathanael L. Brown, Julia Rodriguez-Ramos Fernandez, Michael W. Miller
A rapid field test for sylvatic plague exposure in wild animals A rapid field test for sylvatic plague exposure in wild animals
Plague surveillance is routinely conducted to predict future epizootics in wildlife and exposure risk for humans. The most common surveillance method for sylvatic plague is detection of antibodies to Yersinia pestis F1 capsular antigen in sentinel animals, such as coyotes (Canis latrans). Current serologic tests for Y. pestis, hemagglutination (HA) test and enzyme-linked immunosorbent...
Authors
Rachel C. Abbott, Robert Hudak, Roy Mondesire, Laurie A. Baeten, Robin E. Russell, Tonie E. Rocke
A recombinant raccoon poxvirus vaccine expressing both Yersinia pestis F1 and truncated V antigens protects animals against lethal plague. A recombinant raccoon poxvirus vaccine expressing both Yersinia pestis F1 and truncated V antigens protects animals against lethal plague.
In previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rRCN) expressing Yersinia pestis antigens (F1 and V307-a truncated version of the V protein) provided superior protection against plague challenge compared to individual single antigen constructs. To reduce costs of vaccine production and facilitate...
Authors
Tonie E. Rocke, B Kingstad-Bakke, W Berlier, J.E. Osorio
The innate immune response may be important for surviving plague in wild Gunnison's prairie dogs The innate immune response may be important for surviving plague in wild Gunnison's prairie dogs
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis, with ≥99% mortality reported from multiple studies of plague epizootics. A colony of Gunnison's prairie dogs (Cynomys gunnisoni) in the Aubrey Valley (AV) of northern Arizona appears to have survived several regional epizootics of plague, whereas nearby colonies have been severely affected by Y. pestis. To examine...
Authors
Joseph D. Busch, Roger Van Andel, Nathan E. Stone, Kacy R. Cobble, Roxanne Nottingham, Judy Lee, Michael VerSteeg, Jeff Corcoran, Jennifer Cordova, William E. Van Pelt, Megan M. Shuey, Jeffrey T. Foster, James M. Schupp, Stephen Beckstrom-Sternberg, James Beckstrom-Sternberg, Paul Keim, Susan Smith, Julia Rodriguez-Ramos, Judy L. Williamson, Tonie E. Rocke, David M. Wagner
Mapping monkeypox transmission risk through time and space in the Congo Basin Mapping monkeypox transmission risk through time and space in the Congo Basin
Monkeypox is a major public health concern in the Congo Basin area, with changing patterns of human case occurrences reported in recent years. Whether this trend results from better surveillance and detection methods, reduced proportions of vaccinated vs. non-vaccinated human populations, or changing environmental conditions remains unclear. Our objective is to examine potential...
Authors
Yoshinori J. Nakazawa, R. Ryan Lash, Darin S. Carroll, Inger K. Damon, Kevin L. Karem, Mary G. Reynolds, Jorge E. Osorio, Tonie E. Rocke, Jean Malekani, Jean-Jacques Muyembe, Pierre Formenty, A. Townsend Peterson