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Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents

January 1, 1993

In recent years contamination of the Great Lakes ecosystem with planar chlorinated hydrocarbons (PCHs) has attracted considerable concern due to their known reproductive and teratogenic effects. The H4IIE bioassay has been standardized as a means of measuring the biological potency of a PCH mixture as 2,3,7,8-tetrachloro-p-dibenzodioxin equivalents (TCDD-EQ). Using this bioassay we have investigated the biomagnification of TCDD-EQ in a semi-closed ecosystem. The biomagnification of TCDD-EQ is demonstrated and results indicate that the food chain is the major pathway for TCDD-EQ through this ecosystem. The H4IIE assay system is demonstrated to be a viable integrative measure of the total concentration of TCDD-EQ in different trophic levels.

Citation Information

Publication Year 1993
Title Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents
DOI 10.1016/0045-6535(93)90206-K
Authors P.D. Jones, G.T. Ankley, D. A. Best, R. Crawford, N. DeGalan, J.P. Giesy, T.J. Kubiak, J. P. Ludwig, J.L. Newsted, D. E. Tillitt, D.A. Verbrugge
Publication Type Article
Publication Subtype Journal Article
Series Title Chemosphere
Series Number
Index ID 70177919
Record Source USGS Publications Warehouse
USGS Organization Columbia Environmental Research Center