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Effects of selected polybrominated diphenyl ether flame retardants on lake trout (Salvelinus namaycush) thymocyte viability, apoptosis, and necrosis

January 1, 2005

Polybrominated diphenyl ether (PBDE) flame-retardants have been identified as an emergent contaminants issue in many parts of the world. In vitro analyses were conducted to test the hypothesis that selected PBDEs congeners affect viability, apoptosis, and necrosis of thymocytes from laboratory-reared lake trout (Salvelinus namaycush). At current environmental levels (<1 mg/L), effects of the tested PBDEs on thymocytes were negligible. However, at 100 mg/L, major effects were seen for congener brominated diphenyl ether 47 (BDE-47) and minor effects were seen for congener BDE-99.

Citation Information

Publication Year 2005
Title Effects of selected polybrominated diphenyl ether flame retardants on lake trout (Salvelinus namaycush) thymocyte viability, apoptosis, and necrosis
DOI 10.1897/04-347R.1
Authors Kelly L. Birchmeier, Kimberly A. Smith, Dora R. Passino-Reader, Leonard I. Sweet, Sergei M. Chernyak, Jean V. Adams, Geneva M. Omann
Publication Type Article
Publication Subtype Journal Article
Series Title Environmental Toxicology and Chemistry
Series Number
Index ID 1001080
Record Source USGS Publications Warehouse
USGS Organization Great Lakes Science Center