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Experimental infection of meadow voles (Microtus pennsylvanicus) with sheep scrapie

January 1, 2015

Meadow voles (Microtus pennsylvanicus) are permissive to chronic wasting disease (CWD) infection, but their susceptibility to other transmissible spongiform encephalopathies (TSEs) is poorly characterized. In this initial study, we intracerebrally challenged 6 meadow voles with 2 isolates of sheep scrapie. Three meadow voles acquired a TSE after the scrapie challenge and an extended incubation period. The glycoform profile of proteinase K-resistant prion protein (PrP(res)) in scrapie-sick voles remained similar to the sheep inocula, but differed from that of voles clinically affected by CWD. Vacuolization patterns and disease-associated prion protein (PrP(Sc)) deposition were generally similar in all scrapie-affected voles, except in the hippocampus, where PrP(Sc) staining varied markedly among the animals. Our results demonstrate that meadow voles can acquire a TSE after intracerebral scrapie challenge and that this species could therefore prove useful for characterizing scrapie isolates.

Citation Information

Publication Year 2015
Title Experimental infection of meadow voles (<i>Microtus pennsylvanicus</i>) with sheep scrapie
DOI
Authors CM Carlson, Jay R. Schneider, Janice C. Pedersen, Dennis M. Heisey, Christopher J. Johnson
Publication Type Article
Publication Subtype Journal Article
Series Title Canadian Journal of Veterinary Research
Series Number
Index ID 70146550
Record Source USGS Publications Warehouse
USGS Organization National Wildlife Health Center