Isoneosolaniol (4,8-diacetoxy-12,13-epoxytrichothec-9-ene-3,15-diol) and other unidentified trichothecene mycotoxins were isolated from culture extracts of two highly toxigenic strains of Fusarium compactum cultured from waste peanuts involved in an acute intoxication of sandhill cranes (Grus canadensis). Neosolaniol and other unidentified trichothecenes were detected in waste peanuts collected from affected areas. The structure of isoneosolaniol was determined by 1H and 13C NMR analyses and by high-resolution mass spectometry. Isoneosolaniol was hightly toxic to 1-day-old chickens and to a HEp2 cell culture assay. It was concluded that the most logical cause of the sandhill crane intoxication was Fusarium spp. Contaminated peanuts and various trichothecene mycotoxins acting alone or in conjunction with other Fusarium mycotoxins.
|Title||Isolation and identification of trichothecenes from Fusarium compactum suspected in the aetiology of a major intoxication of sandhill cranes|
|Authors||Richard J. Cole, Joe W. Dorner, John Gilbert, David N. Mortimer, Colin Crews, J.C. Mitchell, Ronald M. Windingstad, Paul E. Nelson, Horace G. Cutler|
|Publication Subtype||Journal Article|
|Series Title||Journal of Agricultural and Food Chemistry|
|Record Source||USGS Publications Warehouse|
|USGS Organization||National Wildlife Health Center|