On March 31, and May 4 and 5, 1973, the first Earth Resources Technology Satellite (ERTS-1) obtained multispectral scanner imagery over the Mississippi River below St. Louis, Missouri. The river was in flood, and the ERTS data provided the first opportunity for regional synoptic mapping of the extent of flooding at the time the imagery was obtained along a 1200 river-mile reach and some of its tributaries. The flood data were compared with imagery collected by ERTS on October 1 and 2, 1972, when the rivers were confined to their normal channels. The specially processed data were analyzed by additive-color techniques, and special enhancements were prepared to aid in interpretation of the data. The extent of flooding was delineated by additive-color, temporal composites of MSS band 7 infrared images. The temporal composites vividly depict, on a single scene, the flooded areas in relation to the normal channel. Color composites of the two near-infrared bands, which usually accentuate surface water, were enlarged to a scale of 1:250,000. Excellent registration was obtained between the image and transparencies of the 1:250,000 topographic maps used as overlays. The resulting image maps were then used as an interim product for preparation of maps showing the extent of flooding at the same scale.