This chapter addresses the immediately south of the Cascades in the Sierra Nevada bioregion, extending nearly half the length of the state of California. This bioregion is one of the most striking features of the state of California, extending from the southern Cascade Mountains in the north to the Tehachapi Mountains and Mojave Desert 700 km to the south. Moreover, the fire responses of important species and fire regime-plant community interactions in the foothill shrubland and the woodland zone, the lower-montane forest ecological zone, the upper-montane forest, the subalpine forest, the alpine meadow, and the shrubland zone and eastside forest and woodland are explained. The success of the management of the Sierra Nevada is contingent on the ability and willingness to keep fire an integral part of these ecosystems.