A computer model of hydrologic and water-quality processes of the Irondequoit Creek basin in Monroe and Ontario Counties, N.Y., was developed during 2000-02 to enable water-resources managers to simulate the effects of future development and stormwater-detention basins on peak flows and water quality of Irondequoit Creek and its tributaries. The model was developed with the program Hydrological Simulation Program-Fortran (HSPF) such that proposed or hypothetical land-use changes and instream stormwater-detention basins could be simulated, and their effects on peak flows and loads of total suspended solids, total phosphorus, ammonia-plus-organic nitrogen, and nitrate-plus-nitrite nitrogen could be analyzed, through an interactive computer program known as Generation and Analysis of Model Simulation Scenarios for Watersheds (GenScn). This report is a user's manual written to guide the Irondequoit Creek Watershed Collaborative in (1) the creation of land-use and flow-detention scenarios for simulation by the HSPF model, and (2) the use of GenScn to analyze the results of these simulations. These analyses can, in turn, aid the group in making basin-wide water-resources-management decisions.