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Stimulation of coho salmon growth by insulin-like growth factor I

January 1, 1992

The effect of insulin-like growth factor I on growth rate of coho salmon (Oncorhynchus kisutch) was examined. Juvenile coho salmon received implants of osmotic minipumps containing recombinant bovine insulin-like growth factor I (rbIGF-I) or saline for a period of 3 to 4 weeks. High doses of rbIGF-I (>0.13 μg · g−1 · d−1) resulted in hypoglycemia and death. In 2-year-old coho salmon, 0.09 μg · g−1 · d−1 rbIGF-I administered for 25 days doubled linear growth rate and increased growth rate in weight by 40%. In rapidly growing, 1-year-old coho salmon, growth rate was not altered by rbIGF-I at 0.01 or 0.05 μg · g−1 · d−1 for 31 days. In ration-limited fish exhibiting slow growth in the control group, rbIGF-I (0.02 to 0.12 μg · g−1 · d−1) increased linear growth rate by up to threefold and growth rate in weight by up to fourfold. The results indicate that exogenous treatment with mammalian IGF-I can stimulate coho salmon growth under some conditions, and that endogenous IGF-I may be an important factor in regulating growth of teleosts.

Publication Year 1992
Title Stimulation of coho salmon growth by insulin-like growth factor I
DOI 10.1016/0016-6480(92)90064-Q
Authors S. D. McCormick, K.M. Kelley, G. Young, R. S. Nishioka, H. A. Bern
Publication Type Article
Publication Subtype Journal Article
Series Title General and Comparative Endocrinology
Index ID 1014564
Record Source USGS Publications Warehouse
USGS Organization Leetown Science Center