Forest cover is of great interest to a variety of scientific and land management applications, many of which require not only information on forest categories, but also tree canopy density. In previous studies, large area tree canopy density had been estimated at spatial resolutions of 1km or coarser using coarse resolution satellite images. In this study, a strategy is developed for estimating tree canopy density at a spatial resolution of 30 m. This strategy is based on empirical relationships between tree canopy density and Landsat data, established using linear regression and regression tree techniques. One-meter digital orthophoto quadrangles were used to derive reference tree canopy density data needed for calibrating the relationships between canopy density and Landsat spectral data. This strategy was tested over three areas of the United States. In general, models derived using both linear regression and regression tree techniques were statistically significant. The regression tree was found more robust than linear regression, primary due to its capability of approximating complex non-linear relationships using a set of linear equations. This strategy will be recommended for use in developing a nation wide tree canopy density data set at a 30 m resolution as part of the Multi-Resolution Land Characteristics 2000 project.