More than 6,500 nonindigenous species are now established in the United States, posing risks to human and wildlife health, native plants and animals, and our valued ecosystems. The annual environmental, economic, and health-related costs of invasive species are substantial. Invasive species can drive native species onto the endangered species list, resulting in associated regulatory costs; exacerbate the threat of wildland fire, which destroys property and threatens lives; increase the cost of delivering water and power; damage infrastructure; and degrade recreation opportunities and discourage tourism. The U.S. Geological Survey (USGS) works with sister agencies in the U.S. Department of the Interior (DOI) and other Federal, State, and territorial agencies, Tribes, and other stakeholders to provide information and tools needed to help solve problems posed by invasive species across the country. Key components of USGS invasive species science include developing novel prevention, forecasting, early detection, decision support, and control tools.