Donald Tillitt, PhD (Former Employee)
Science and Products
Filter Total Items: 215
Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology
The effects of consumption of environmental contaminants contained in carp (Cyprinus carpio)from Saginaw Bay, Michigan on various hematological parameters and liver integrity of adult female mink (Mustela vison) were determined. Mink were fed diets that contained 0 (control), 10, 20, or 40% carp prior to and throughout the reproductive period (182 days). The diets contained 0.015, 0.72...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout
This study was undertaken to evaluate the relationship between mammalian and piscine 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalency factors (TEFs) for PCBs, based on induction of CYP1A enzyme activity, catalytic protein, and mRNA. Rainbow trout administered a single i.p. injection of TCDD had an average (±SD) ED50 of 0.91 ± 0.14 μg TCDD/kg for induction of ethoxyresorufin O
Authors
John L. Newsted, Paul D. Jones, John P. Giesy, Robert A. Crawford, Gerald T. Ankley, Donald E. Tillitt, Jay W. Gooch, Michael S. Denison
Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations
Carp (Cyprinus carpio) collected from Saginaw Bay, Michigan, containing 8.4 mg total polychlorinated biphenyls (PCBs)/kg and 194 ng of 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents (TEQs)/kg, were substituted for marine fish at levels of 0, 10, 20, or 40% in the diets of adult ranch mink (Mustela vison). The diets, containing 0.015, 0.72, 1.53, and 2.56 mg PCBs/kg diet, or 1.03, 19.41...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon
No abstract available.
Authors
Kevin P. Feltz, Donald E. Tillitt, Robert W. Gale, Paul H. Peterman
Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification
Mink are known to be very sensitive to the toxic effects of planar polychlorinated biphenyls (pPCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), collectively known as planar halogenated hydrocarbons (PHHs). Previously, we reported the reproductive effects in mink fed a diet containing 10, 20, or 40% fish taken from Saginaw Bay, Lake Huron. The...
Authors
Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajicek, Paul H. Peterman, Silvia N. Heaton, Paul D. Jones, Steven J. Bursian, Timothy J. Kubiak, John P. Giesy, Richard J. Aulerich
Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations
Semipermeable membrane devices (SPMDs) were used to passively sample aqueous polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in Bayou Meto, AR. The two sites were upstream and downstream from the confluence with a tributary that delivers PCDDs and PCDFs to the Bayou. Following dialysis, cleanup, and fractionation, four replicate 17-9 SPMD samples from...
Authors
Jon A. Lebo, Robert W. Gale, Jimmie D. Petty, Donald E. Tillitt, James N. Huckins, John C. Meadows, Carl E. Orazio, Kathy R. Echols, Dennis J. Schroeder, Lloyd E. Inmon
Deformities in birds of the Great Lakes region. Assigning causality Deformities in birds of the Great Lakes region. Assigning causality
No abstract available.
Authors
John P. Giesy, James P. Ludwig, Donald E. Tillitt
A toxic equivalency factor scale for polychlorinated dibenzofurans A toxic equivalency factor scale for polychlorinated dibenzofurans
The ethoxyresorufin O-deethylase (EROD) induction of 20 polychiorinated dibenzofurans (PCDFs) was examined in the H4IIE rat hepatoma cell bioassay. The selection of the compounds tested was based on a multivariate chemical characterization laying the groundwork for covering the whole chemical series of PCDFs. The EROD induction potency was found to vary in ED50 values from 25 to 100,000...
Authors
M. Tysklind, D. Tillitt, L. Eriksson, K. Lundgren, C. Rappe
Relation among cytochrome P450, AH-active PCB congeners and dioxin equivalents in pipping black-crowned night-heron embryos Relation among cytochrome P450, AH-active PCB congeners and dioxin equivalents in pipping black-crowned night-heron embryos
Pipping black-crowned night-heron (Nycticorax nycticorax) embryos were collected from a relatively uncontaminated site (next to Chincoteague National Wildlife Refuge, VA) and three polluted sites (Cat Island, Green Bay, Lake Michigan, WI; Bair Island, San Francisco Bay, CA; West Marin Island, San Francisco Bay, CA). Hepatic cytochrome P-450-associated monooxygenases and cytochrome P-450...
Authors
Barnett A. Rattner, Jeff S. Hatfield, M. J. Melancon, T. W. Custer, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink
Populations of mink (Mustela vison) have declined in many areas of the world. Such declines have been linked to exposures to synthetic, halogenated hydrocarbons. In the Great Lakes region, mink are fewer in areas along the shore of the Great Lakes and their tributaries where mink have access to fish from the Great Lakes. Recently, there has been discussion of the relative merits of...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury
Fishes of the Great Lakes contain hazardous chemicals such as synthetic halogenated hydrocarbons and metals. These fish can move from the lakes into the Great Lakes tributaries of Michigan. In doing so, they transport concentrationsof contaminants which may represent a risk to wildlife. Concentrations of mercury (Hg), total polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, M. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds
No abstract available.
Authors
J. P. Giesy, J. P. Ludwig, D. E. Tillitt
Science and Products
Filter Total Items: 215
Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology
The effects of consumption of environmental contaminants contained in carp (Cyprinus carpio)from Saginaw Bay, Michigan on various hematological parameters and liver integrity of adult female mink (Mustela vison) were determined. Mink were fed diets that contained 0 (control), 10, 20, or 40% carp prior to and throughout the reproductive period (182 days). The diets contained 0.015, 0.72...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout
This study was undertaken to evaluate the relationship between mammalian and piscine 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalency factors (TEFs) for PCBs, based on induction of CYP1A enzyme activity, catalytic protein, and mRNA. Rainbow trout administered a single i.p. injection of TCDD had an average (±SD) ED50 of 0.91 ± 0.14 μg TCDD/kg for induction of ethoxyresorufin O
Authors
John L. Newsted, Paul D. Jones, John P. Giesy, Robert A. Crawford, Gerald T. Ankley, Donald E. Tillitt, Jay W. Gooch, Michael S. Denison
Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations
Carp (Cyprinus carpio) collected from Saginaw Bay, Michigan, containing 8.4 mg total polychlorinated biphenyls (PCBs)/kg and 194 ng of 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents (TEQs)/kg, were substituted for marine fish at levels of 0, 10, 20, or 40% in the diets of adult ranch mink (Mustela vison). The diets, containing 0.015, 0.72, 1.53, and 2.56 mg PCBs/kg diet, or 1.03, 19.41...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon
No abstract available.
Authors
Kevin P. Feltz, Donald E. Tillitt, Robert W. Gale, Paul H. Peterman
Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification
Mink are known to be very sensitive to the toxic effects of planar polychlorinated biphenyls (pPCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), collectively known as planar halogenated hydrocarbons (PHHs). Previously, we reported the reproductive effects in mink fed a diet containing 10, 20, or 40% fish taken from Saginaw Bay, Lake Huron. The...
Authors
Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajicek, Paul H. Peterman, Silvia N. Heaton, Paul D. Jones, Steven J. Bursian, Timothy J. Kubiak, John P. Giesy, Richard J. Aulerich
Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations
Semipermeable membrane devices (SPMDs) were used to passively sample aqueous polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in Bayou Meto, AR. The two sites were upstream and downstream from the confluence with a tributary that delivers PCDDs and PCDFs to the Bayou. Following dialysis, cleanup, and fractionation, four replicate 17-9 SPMD samples from...
Authors
Jon A. Lebo, Robert W. Gale, Jimmie D. Petty, Donald E. Tillitt, James N. Huckins, John C. Meadows, Carl E. Orazio, Kathy R. Echols, Dennis J. Schroeder, Lloyd E. Inmon
Deformities in birds of the Great Lakes region. Assigning causality Deformities in birds of the Great Lakes region. Assigning causality
No abstract available.
Authors
John P. Giesy, James P. Ludwig, Donald E. Tillitt
A toxic equivalency factor scale for polychlorinated dibenzofurans A toxic equivalency factor scale for polychlorinated dibenzofurans
The ethoxyresorufin O-deethylase (EROD) induction of 20 polychiorinated dibenzofurans (PCDFs) was examined in the H4IIE rat hepatoma cell bioassay. The selection of the compounds tested was based on a multivariate chemical characterization laying the groundwork for covering the whole chemical series of PCDFs. The EROD induction potency was found to vary in ED50 values from 25 to 100,000...
Authors
M. Tysklind, D. Tillitt, L. Eriksson, K. Lundgren, C. Rappe
Relation among cytochrome P450, AH-active PCB congeners and dioxin equivalents in pipping black-crowned night-heron embryos Relation among cytochrome P450, AH-active PCB congeners and dioxin equivalents in pipping black-crowned night-heron embryos
Pipping black-crowned night-heron (Nycticorax nycticorax) embryos were collected from a relatively uncontaminated site (next to Chincoteague National Wildlife Refuge, VA) and three polluted sites (Cat Island, Green Bay, Lake Michigan, WI; Bair Island, San Francisco Bay, CA; West Marin Island, San Francisco Bay, CA). Hepatic cytochrome P-450-associated monooxygenases and cytochrome P-450...
Authors
Barnett A. Rattner, Jeff S. Hatfield, M. J. Melancon, T. W. Custer, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink
Populations of mink (Mustela vison) have declined in many areas of the world. Such declines have been linked to exposures to synthetic, halogenated hydrocarbons. In the Great Lakes region, mink are fewer in areas along the shore of the Great Lakes and their tributaries where mink have access to fish from the Great Lakes. Recently, there has been discussion of the relative merits of...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury
Fishes of the Great Lakes contain hazardous chemicals such as synthetic halogenated hydrocarbons and metals. These fish can move from the lakes into the Great Lakes tributaries of Michigan. In doing so, they transport concentrationsof contaminants which may represent a risk to wildlife. Concentrations of mercury (Hg), total polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, M. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds
No abstract available.
Authors
J. P. Giesy, J. P. Ludwig, D. E. Tillitt
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