Durga Ghosh

Durga Ghosh, Ph.D.

QA Coordinator,

Chesapeake Bay Program

MD-DE-DC Water Science Center

email: dghosh@chesapeakebay.net

email: dghosh@usgs.gov

Phone: 410-267-5750

Address: 410 Severn Avenue, Annapolis, MD 21403

Biography

BIOGRAPHY

Expertise

Durga is a QA Coordinator working for the US Geological Survey at the Chesapeake Bay
Program Office in Annapolis, Maryland. She provides technical support for the water quality
and quality assurance activities of the Chesapeake Bay Program. She also serves as the technical
lead for quality assessment of proposals funded by EPA through an interagency agreement with
the CBP. She is also responsible for the audit and assessment of the quality systems of the state
partners and other division grantees.

Education

  • Ph.D., Biochemistry. Department of Life Sciences, University of Bombay, India
  • M.S., Biotechnical Sciences. Department of Life Sciences, University of Bombay, India
  • B.S., Microbiology and Environmental Biology. Department of Microbiology, University of Bombay, India

Professional Experience

  • Oct. 2017-Present Quality Assurance Coordinator, Chesapeake Bay Program Office Quality Management System, Annapolis, MD
  • Nov. 2015-Sep. 2017 Chemist, U.S. Geological Survey, Baltimore, MD
  • June 2015-Nov. 2015 Scientist III, U.S. Geological Survey, Baltimore, MD
  • June 2007-May 2015 Research Associate, The Pennsylvania State University, State College, PA
  • Apr. 1998-May 2007 Postdoctoral Researcher, The Pennsylvania State University, StateCollege, PA

Professional Responsibilities

  • 2011-2015 Alternate member, University Faculty Senate
  • 2009-2012 Climate and Diversity Committee, Eberly College of Science, The Pennsylvania State University

Teaching Experience

  • Lecturer, Genetics and Biotechnology, Department of Life Sciences, Jai Hind College, University of Bombay
  • Lecturer, Environmental Chemistry, Microbiology, and Ecology, Garware Institute of Career Education and Development, University of Bombay

Professional Affiliations

  • The American Chemical Society
  • The RNA Society

Selected Peer-Reviewed Publications

  • Kranick, J.C., Chadalavada, D.M., Sahu, D., and Showalter, S.A. 2017. Engineering double-stranded binding activity into the Drosha double-stranded RNA binding domain results in loss of MicroRNA processing function. PLOS ONE, e0182445
  • Quarles, K.A., Chadalavada, D.M., and Showalter, S.A. 2015. Deformability in the cleavage site of primary MicroRNA is not sensed by the double-stranded RNA binding domains in the Microprocessor component DGCR8. Proteins: Structure, Function, and Bioinformatics 83, 1165
  • Chadalavada, D.M., Gratton, E.A., and Bevilacqua, P.C. 2010. The human HDV-like CPEB3 ribozyme is intrinsically fast-reacting. Biochemistry, 49, 5321. Featured Article
  • Chen, J-H., Yajima, R., Chadalavada, D.M., Chase, E., Bevilacqua, P.C., and Golden, B.L. 2010. A 1.9 Å crystal structure of the HDV ribozyme pre-cleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage. Biochemistry, 49, 6508
  • Gong, B., Chen, Y., Christian, E.L., Chen, J-H., Chase, E., Chadalavada, D.M., Yajima, R., Golden, B.L., Bevilacqua, P.C., and Carey, P.R. 2008. Detection of innersphere interactions between magnesium hydrate and the phosphate backbone of the HDV ribozyme using Raman crystallography. J. Am. Chem. Soc., 130, 9670
  • Chadalavada, D.M., Senchak, S.E., and Bevilacqua, P.C. 2002. The folding pathway of the genomic hepatitis delta virus ribozyme is dominated by slow folding of the pseudoknots. J. Mol. Biol., 317, 559
  • Chadalavada, D.M., Knudsen, S.M., Nakano, S., and Bevilacqua, P.C. 2000. A role for upstream RNA structure in facilitating the catalytic fold of the genomic hepatitis delta virus ribozyme. J. Mol. Biol., 301, 349
  • Nakano, S., Chadalavada, D.M., and Bevilacqua, P.C. 2000. General acid-base catalysis in the mechanism of an HDV Ribozyme. Science, 287, 1493

Published Book Chapters

  • Chadalavada, D.M.*, Cerrone-Szakal, A.L., Wilcox, J.L., Siegfried, N.A., and Bevilacqua, P.C. 2012. Mechanistic analysis of the Hepatitis Delta Virus (HDV) ribozyme: methods for RNA preparation, structure mapping, solvent isotope effects, and co-transcriptional cleavage. Methods in Molecular Biology, Vol. 848, Springer. * Corresponding Author
  • Gong, B., Chen, J-H., Yajima, R., Chen, Y., Chase, E., Chadalavada, D.M., Golden, B.L., Carey, P.R., and Bevilacqua, P.C. 2009. Raman crystallography of RNA. Methods, Vol. 49, Elsevier Inc.
  • Chadalavada, D.M., and Bevilacqua, P.C. 2009. Analyzing RNA and DNA folding using Temperature Gradient Gel Electrophoresis (TGGE) with application to in vitro selections. Methods in Enzymology, Vol. 468, Academic Press
  • Bevilacqua, P.C., Brown, T.S., Chadalavada, D.M., Parente, A.D., and Yajima, R. 2003. Kinetic analysis of ribozyme cleavage. Kinetic Analysis of Molecules: A Practical Approach, Oxford University Press