Jeff Meinertz (Former Employee)
Science and Products
Marker residue depletion from the skin-on fillet tissue of rainbow trout exposed to AQUI S 20E:
Among the data required by the U.S. Food and Drug Administration (FDA) for approval of an aquaculture drug are the data that characterize the depletion of a drugs marker residue from the edible fillet tissue of fish after exposure. Eugenol is the marker residue for AQUI-S 20E, a product proposed for use as a sedative for fish.Rainbow trout (Onchorynchus mykiss; a representative cold water fish sp
Filter Total Items: 32
Evaluation of a method for quantifying eugenol concentrations in the fillet tissue from freshwater fish species
AQUI-S 20E® (active ingredient, eugenol; AQUI-S New Zealand Ltd, Lower Hutt, New Zealand) is being pursued for approval as an immediate-release sedative in the United States. A validated method to quantify the primary residue (the marker residue) in fillet tissue from AQUI-S 20E–exposed fish was needed. A method was evaluated for determining concentrations of the AQUI-S 20E marker residue, eugenol
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Scott T. Porcher, Justin Smerud
Florfenicol residues in Rainbow Trout after oral dosing in recirculating and flow-through culture systems
Aquaflor is a feed premix for fish containing the broad spectrum antibacterial agent florfenicol (FFC) incorporated at a ratio of 50% (w/w). To enhance the effectiveness of FFC for salmonids infected with certain isolates of Flavobacterium psychrophilum causing coldwater disease, the FFC dose must be increased from the standard 10 mg·kg−1 body weight (BW)·d−1 for 10 consecutive days. A residue dep
Authors
Jeffery R. Meinertz, Karina R. Hess, Jeffry A. Bernady, M. P. Gaikowski, Melissa Whitsel, R. G. Endris
Determination of the exposure parameters that maximise the concentrations of the anaesthetic/sedative eugenol in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue
Studies were conducted to determine the anaesthetic/sedative concentrations and durations that would maximize anaesthetic/sedative residue concentrations in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue. Rainbow trout (167–404 g) were exposed to 50 mg l−1 AQUI-S® 20E (10% active ingredient, eugenol) in 17°C freshwater for durations up to 1440 min, 100 and 250 mg l−1 AQUI-S® 20E for dur
Authors
Jeffery R. Meinertz, Scott T. Porcher, Justin Smerud
Depletion of eugenol residues from the skin-on fillet tissue of rainbow trout exposed to 14C-labeled eugenol
The U.S. is lagging in access to an approved immediate-release sedative, i.e. a compound that can be safely and effectively used to sedate fish and has no withdrawal period. AQUI-S® 20E (10% active ingredient, eugenol) is under investigation as an immediate-release sedative for freshwater finfish. Because of its investigational status, data are needed to characterize the depletion, distribution, a
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Scott T. Porcher, Justin Smerud, Mark P. Gaikowski
Evaluation of analytical techniques to determine AQUI-S® 20E (eugenol) concentrations in water
There is a critical need in U.S. public aquaculture and fishery management programs for an immediate-release sedative, i.e. a compound that can be safely and effectively used to sedate fish and subsequently, allow for their immediate release. AQUI-S® 20E (10% active ingredient, eugenol; any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the
Authors
Jeffery R. Meinertz, Karina R. Hess
Feeding response of sport fish after electrical immobilization, chemical sedation, or both
Fishery managers frequently capture wild fish for a variety of fishery management activities. Though some activities can be accomplished without immobilizing the fish, others are accomplished more readily, humanely, and safely (for both the handler and the fish) when fish are immobilized by physical (e.g., electrical immobilization) or chemical sedation. A concern regarding the use of chemical sed
Authors
Jeffery R. Meinertz, Kim T. Fredricks, Ryan D. Ambrose, Leanna M. Jackan, Jeremy K. Wise
Survival and growth of newly transformed Lampsilis cardium and Lampsilis siliquoidea in a flow-through, continuous feeding test system
A test system was evaluated for assessing chronic toxicity of waterborne chemicals with early life stage mussels. To determine if the test system could result in ≥80% survival in a control (unexposed) group, fat mucket mussels (Lampsilis siliquoidea Barnes, 1823) and plain pocketbook mussels (L. cardium Rafinesque, 1820) 1 day post transformation were stocked into test chambers (250 mL beakers, wa
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Karina R. Hess, Michelle Bartsch
Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Diphenhydramine hydrochloride (DH; Benadryl™, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to E
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Jeffry A. Bernardy, Jeanne L. Franz
Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system
Approval of a new animal drug application for AQUAMYCIN 100® (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ET’s impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on
Authors
J.R. Meinertz, Theresa M. Schreier, J.A. Bernardy
Depletion of florfenicol amine, marker residue of florfenicol, from the edible fillet of tilapia (Oreochromis niloticus x O. niloticus and O. niloticus x O. aureus) following florfenicol administration in feed
Aquaflor??, a 50% feed premix containing the broad spectrum antibacterial agent florfenicol is available globally to control mortality associated with economically significant systemic bacterial diseases of fish. Florfenicol (FFC) is effective in controlling mortality associated with Streptococcus iniae in tilapia Oreochromis sp. when administered in medicated feed at a dose of 15 mg/kg bodyweight
Authors
M.P. Gaikowski, M. Mushtaq, P. Cassidy, J.R. Meinertz, S.M. Schleis, D. Sweeney, R.G. Endris
Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Diphenhydramine hydrochloride (DH; Benadryl TM, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 lg/L for 21 days or to
Authors
J.R. Meinertz, Theresa M. Schreier, J.A. Bernardy, J.L. Franz
Depletion of isoeugenol residues from the fillet tissue of AQUI-S™ exposed rainbow trout (Oncorhynchus mykiss)
There is a critical need in U.S. public aquaculture and fishery management for an approved sedative that allows for the immediate release of fish after sedation. AQUI-STM is a fish anesthetic/sedative approved for use in several countries and until recently was being developed in the U.S. as a sedative for immediate release of fish after sedation. The U.S. National Toxicology Program reported that
Authors
Jeffery R. Meinertz, Theresa M. Schreier
Science and Products
Marker residue depletion from the skin-on fillet tissue of rainbow trout exposed to AQUI S 20E:
Among the data required by the U.S. Food and Drug Administration (FDA) for approval of an aquaculture drug are the data that characterize the depletion of a drugs marker residue from the edible fillet tissue of fish after exposure. Eugenol is the marker residue for AQUI-S 20E, a product proposed for use as a sedative for fish.Rainbow trout (Onchorynchus mykiss; a representative cold water fish sp
Filter Total Items: 32
Evaluation of a method for quantifying eugenol concentrations in the fillet tissue from freshwater fish species
AQUI-S 20E® (active ingredient, eugenol; AQUI-S New Zealand Ltd, Lower Hutt, New Zealand) is being pursued for approval as an immediate-release sedative in the United States. A validated method to quantify the primary residue (the marker residue) in fillet tissue from AQUI-S 20E–exposed fish was needed. A method was evaluated for determining concentrations of the AQUI-S 20E marker residue, eugenol
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Scott T. Porcher, Justin Smerud
Florfenicol residues in Rainbow Trout after oral dosing in recirculating and flow-through culture systems
Aquaflor is a feed premix for fish containing the broad spectrum antibacterial agent florfenicol (FFC) incorporated at a ratio of 50% (w/w). To enhance the effectiveness of FFC for salmonids infected with certain isolates of Flavobacterium psychrophilum causing coldwater disease, the FFC dose must be increased from the standard 10 mg·kg−1 body weight (BW)·d−1 for 10 consecutive days. A residue dep
Authors
Jeffery R. Meinertz, Karina R. Hess, Jeffry A. Bernady, M. P. Gaikowski, Melissa Whitsel, R. G. Endris
Determination of the exposure parameters that maximise the concentrations of the anaesthetic/sedative eugenol in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue
Studies were conducted to determine the anaesthetic/sedative concentrations and durations that would maximize anaesthetic/sedative residue concentrations in rainbow trout (Oncorhynchus mykiss) skin-on fillet tissue. Rainbow trout (167–404 g) were exposed to 50 mg l−1 AQUI-S® 20E (10% active ingredient, eugenol) in 17°C freshwater for durations up to 1440 min, 100 and 250 mg l−1 AQUI-S® 20E for dur
Authors
Jeffery R. Meinertz, Scott T. Porcher, Justin Smerud
Depletion of eugenol residues from the skin-on fillet tissue of rainbow trout exposed to 14C-labeled eugenol
The U.S. is lagging in access to an approved immediate-release sedative, i.e. a compound that can be safely and effectively used to sedate fish and has no withdrawal period. AQUI-S® 20E (10% active ingredient, eugenol) is under investigation as an immediate-release sedative for freshwater finfish. Because of its investigational status, data are needed to characterize the depletion, distribution, a
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Scott T. Porcher, Justin Smerud, Mark P. Gaikowski
Evaluation of analytical techniques to determine AQUI-S® 20E (eugenol) concentrations in water
There is a critical need in U.S. public aquaculture and fishery management programs for an immediate-release sedative, i.e. a compound that can be safely and effectively used to sedate fish and subsequently, allow for their immediate release. AQUI-S® 20E (10% active ingredient, eugenol; any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the
Authors
Jeffery R. Meinertz, Karina R. Hess
Feeding response of sport fish after electrical immobilization, chemical sedation, or both
Fishery managers frequently capture wild fish for a variety of fishery management activities. Though some activities can be accomplished without immobilizing the fish, others are accomplished more readily, humanely, and safely (for both the handler and the fish) when fish are immobilized by physical (e.g., electrical immobilization) or chemical sedation. A concern regarding the use of chemical sed
Authors
Jeffery R. Meinertz, Kim T. Fredricks, Ryan D. Ambrose, Leanna M. Jackan, Jeremy K. Wise
Survival and growth of newly transformed Lampsilis cardium and Lampsilis siliquoidea in a flow-through, continuous feeding test system
A test system was evaluated for assessing chronic toxicity of waterborne chemicals with early life stage mussels. To determine if the test system could result in ≥80% survival in a control (unexposed) group, fat mucket mussels (Lampsilis siliquoidea Barnes, 1823) and plain pocketbook mussels (L. cardium Rafinesque, 1820) 1 day post transformation were stocked into test chambers (250 mL beakers, wa
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Karina R. Hess, Michelle Bartsch
Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Diphenhydramine hydrochloride (DH; Benadryl™, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to E
Authors
Jeffery R. Meinertz, Theresa M. Schreier, Jeffry A. Bernardy, Jeanne L. Franz
Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system
Approval of a new animal drug application for AQUAMYCIN 100® (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ET’s impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on
Authors
J.R. Meinertz, Theresa M. Schreier, J.A. Bernardy
Depletion of florfenicol amine, marker residue of florfenicol, from the edible fillet of tilapia (Oreochromis niloticus x O. niloticus and O. niloticus x O. aureus) following florfenicol administration in feed
Aquaflor??, a 50% feed premix containing the broad spectrum antibacterial agent florfenicol is available globally to control mortality associated with economically significant systemic bacterial diseases of fish. Florfenicol (FFC) is effective in controlling mortality associated with Streptococcus iniae in tilapia Oreochromis sp. when administered in medicated feed at a dose of 15 mg/kg bodyweight
Authors
M.P. Gaikowski, M. Mushtaq, P. Cassidy, J.R. Meinertz, S.M. Schleis, D. Sweeney, R.G. Endris
Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
Diphenhydramine hydrochloride (DH; Benadryl TM, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 lg/L for 21 days or to
Authors
J.R. Meinertz, Theresa M. Schreier, J.A. Bernardy, J.L. Franz
Depletion of isoeugenol residues from the fillet tissue of AQUI-S™ exposed rainbow trout (Oncorhynchus mykiss)
There is a critical need in U.S. public aquaculture and fishery management for an approved sedative that allows for the immediate release of fish after sedation. AQUI-STM is a fish anesthetic/sedative approved for use in several countries and until recently was being developed in the U.S. as a sedative for immediate release of fish after sedation. The U.S. National Toxicology Program reported that
Authors
Jeffery R. Meinertz, Theresa M. Schreier