Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system
January 1, 2010
Diphenhydramine hydrochloride (DH; Benadryl TM, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 lg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 (mu or u)g/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 (mu or u)g/L and for ET was 248 (mu or u)g/L.
Citation Information
| Publication Year | 2010 |
|---|---|
| Title | Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to Daphnia, Daphnia magna, in a continuous exposure test system |
| Authors | J.R. Meinertz, Theresa M. Schreier, J.A. Bernardy, J.L. Franz |
| Publication Type | Article |
| Publication Subtype | Journal Article |
| Series Title | Bulletin of Environmental Contamination and Toxicology |
| Index ID | 70003552 |
| Record Source | USGS Publications Warehouse |
| USGS Organization | Upper Midwest Environmental Sciences Center |