Maureen K Purcell, Ph.D. (Former Employee)
Science and Products
Filter Total Items: 14
AquaDePTH-Aquatic Disease and Pathogen Repository
The Aquatic Disease and Pathogen Repository (AquaDePTH) will be a public-facing national repository to support biosurveillance of aquatic animal diseases and pathogens. By collating historically published data, plus new aquatic pathogen and disease information, stakeholders will be able monitor fish kill and aquatic pathogen trends spatially and temporally in freshwater and marine environments...
Partners - FHP
For more than five decades the WFRC Fish Health Program has worked with partners to provide research findings to managers of aquatic resources. Those partners form a network of colleagues, co-investigators, and customers. Our partners include Department of the Interior bureaus, tribal and state fisheries agencies, other federal partners and the private sector.
Fish Health Program Lead Scientists and Areas of Expertise
Lead Scientists - Expertise
Species Studied by the Fish Health Program
List of species studied by the Fish Health Program. These species include bacteria, fish, parasites, and viruses. The list contains both common and scientific names. Descriptions of species and studies can be found under the "Related Science" tab.
Tribal Collaboration - Fish Health Program (FHP)
The Fish Health Program has a strong commitment to respond to requests for research and technical support from Tribal fisheries agencies.
Herring Disease Program
Using an approach that involves a combination of field- and laboratory-based studies, we are investigating fish health factors that may be contributing to the failed recovery of Pacific herring populations in Prince William Sound, AK. Field studies are providing infection and disease prevalence data to inform the population models, serological data that indicate the prior exposure history and...
Entry and spread of specialist and generalist infectious hematopoietic necrosis virus (IHNV) genotypes in Chinook salmon, steelhead and sockeye salmon Entry and spread of specialist and generalist infectious hematopoietic necrosis virus (IHNV) genotypes in Chinook salmon, steelhead and sockeye salmon
Infectious hematopoietic necrosis virus (IHNV) represents one of the most critical challenges for salmonids in the Pacific Northwest. There are three genogroups of IHNV, designated U, M, and L; the U is further delineated into two subgroups, UC and UP, and the M is further delineated into four subgroups (MA – MD). The UP, UC and MD subgroups co-occur in the Columbia River Basin where the...
Detections, Physical Captures, Water Quality, and Fish Health associated with Endangered Suckers in Three Net Pens in Upper Klamath Lake, 2020 Detections, Physical Captures, Water Quality, and Fish Health associated with Endangered Suckers in Three Net Pens in Upper Klamath Lake, 2020
To determine how initial length affects survival of captively-reared juvenile suckers, we introduced Passive Integrated Transponder (PIT) tagged juvenile suckers into three net pens in Upper Klamath Lake. The suckers originated from the U.S. Fish and Wildlife Service's Sucker Assisted Rearing Program in Klamath Falls, Oregon, which rears suckers collected as larvae in Upper Klamath Lake...
Analytical and diagnostic validation of a molecular test to detect and discriminate IHNV genogroups U and M Analytical and diagnostic validation of a molecular test to detect and discriminate IHNV genogroups U and M
Infectious hematopoietic necrosis virus (IHNV) is an acute pathogen of salmonids in North America, Europe and Asia that is phylogenetically classified into five major virus genogroups (U, M, L, E and J). The geographic range of the U and M genogroup isolates overlap in the North American Columbia River Basin and Washington Coast region, where these genogroups pose different risks...
Histological and molecular testing of nuclear inclusion X in Pacific Razor clams from select locations in Washington, USA Histological and molecular testing of nuclear inclusion X in Pacific Razor clams from select locations in Washington, USA
Nuclear inclusion X (NIX), the etiological agent of bacterial gill disease in Pacific razor clams (Siliqua patula) was associated with host mortality events in coastal Washington, USA during the mid-1980s. Ongoing observations of truncated razor clam size distributions in Kalaloch Beach, Washington raised concerns that NIX continues to impact populations. We conducted a series of spatial...
Spatial and temporal survey of waterborne myxozoan parasites in the Lake Sammamish watershed, Washington, from 2019 - 2021 Spatial and temporal survey of waterborne myxozoan parasites in the Lake Sammamish watershed, Washington, from 2019 - 2021
There is a fundamental knowledge gap on the distribution, prevalence, intensity, and ecology of salmonid myxozoan parasites in the Lake Sammamish watershed, Washington. To address this knowledge gap, we tested water samples for Ceratonova shasta, Parvicapsula minibicornis and Tetracapsuloides bryosalmonae DNA from 84 sites distributed throughout the Lake Sammamish watershed in fall 2019...
Survival, viral load and neutralizing antibodies in steelhead trout and cell cultures exposed to infectious hematopoietic necrosis virus (IHNV) at 3 temperatures Survival, viral load and neutralizing antibodies in steelhead trout and cell cultures exposed to infectious hematopoietic necrosis virus (IHNV) at 3 temperatures
Environmental variation has important effects on host-pathogen interactions, affecting large-scale ecological processes such as the severity and frequency of epidemics. However, less is known about how the environment modulates viral fitness traits and within host infection processes. Viral genetic variation, fish host immune response and environmental parameters such as temperature have...
Filter Total Items: 88
Safety and immunogenicity of poultry vaccine for protecting critically endangered avian species against highly pathogenic avian influenza virus, United States Safety and immunogenicity of poultry vaccine for protecting critically endangered avian species against highly pathogenic avian influenza virus, United States
In 2023, an outbreak of highly pathogenic avian influenza occurred among critically endangered California condors (Gymnogyps californianus), and >21 died. We evaluated safety, immunogenicity, vaccination strategies, and correlates of antibody response of an influenza vaccine for poultry in black vultures (Coragyps atratus) and then California condors. We noted differences in antibody...
Authors
Todd E. Katzner, Ashleigh V. Blackford, Mary Donahue, Samantha E.J. Gibbs, Julianna B. Lenoch, Michael K. Martin, Tonie E. Rocke, J. Jeffrey Root, Darren Styles, Sunny Cooper, Kristin Dean, Zachary Dvornicky-Raymond, Dominique Keller, Carlos Sanchez, Brett Dunlap, Thomas Grier, Michael P. Jones, Gregory Nitzel, Erin Patrick, Maureen Purcell, Aaron J. Specht, David L. Suarez
Genome-wide association analysis of the resistance to infectious hematopoietic necrosis virus in two rainbow trout aquaculture lines confirms oligogenic architecture with several moderate effect quantitative trait loci Genome-wide association analysis of the resistance to infectious hematopoietic necrosis virus in two rainbow trout aquaculture lines confirms oligogenic architecture with several moderate effect quantitative trait loci
Infectious hematopoietic necrosis (IHN) is a disease of salmonid fish that is caused by the IHN virus (IHNV), which can cause substantial mortality and economic losses in rainbow trout aquaculture and fisheries enhancement hatchery programs. In a previous study on a commercial rainbow trout breeding line that has undergone selection, we found that genetic resistance to IHNV is controlled...
Authors
Yniv Palti, Roger L. Vallejo, Maureen K. Purcell, Guangtu Gao, Kristy L. Shewbridge, Roseanna L. Long, Christopher Setzke, Breno O. Fragomeni, Hao Cheng, Kyle E. Martin, Kerrry A. Naish
Local and systemic replicative fitness for viruses in specialist, generalist, and non-specialist interactions with salmonid hosts Local and systemic replicative fitness for viruses in specialist, generalist, and non-specialist interactions with salmonid hosts
Host tissues represent diverse resources or barriers for pathogen replicative fitness. We tested whether viruses in specialist, generalist, and non-specialist interactions replicate differently in local entry tissue (fin), and systemic target tissue (kidney) using infectious hematopoietic necrosis virus (IHNV) and three salmonid fish hosts. Virus tissue replication was host specific, but...
Authors
David James Paez, Gael Kurath, Rachel L. Powers, Kerry A. Naish, Maureen K. Purcell
Evaluating the effect of nuclear inclusion X (NIX) infections on Pacific razor clam populations Evaluating the effect of nuclear inclusion X (NIX) infections on Pacific razor clam populations
ABSTRACT: Nuclear inclusion X (NIX), the etiological agent of bacterial gill disease in Pacific razor clams Siliqua patula, was associated with host mortality events in coastal Washington State, USA, during the mid-1980s. Ongoing observations of truncated razor clam size distributions in Kalaloch Beach, Washington, raised concerns that NIX continues to impact populations. We conducted a...
Authors
Maya Groner, Paul Hershberger, Steven C. Fradkin, Carla M. Conway, Aine C. Hawthorn, Maureen K. Purcell
Variation in within-host replication kinetics among virus genotypes provides evidence of specialist and generalist infection strategies across three salmonid host species Variation in within-host replication kinetics among virus genotypes provides evidence of specialist and generalist infection strategies across three salmonid host species
Theory of the evolution of pathogen specialization suggests that a specialist pathogen gains high fitness in one host, but this comes with fitness loss in other hosts. By contrast, a generalist pathogen does not achieve high fitness in any host, but gains ecological fitness by exploiting different hosts, and has higher fitness than specialists in nonspecialized hosts. As a result...
Authors
David James Paez, Douglas G. McKenney, Maureen K. Purcell, Kerry A. Naish, Gael Kurath
A phylogeny based on cytochrome-c oxidase gene sequences identifies sympatric Ichthyophonus genotypes in the NE Pacific Ocean A phylogeny based on cytochrome-c oxidase gene sequences identifies sympatric Ichthyophonus genotypes in the NE Pacific Ocean
ABSTRACT: In recent decades, evidence has accumulated to suggest that the widespread and highly variable parasite Ichthyophonus hoferi is actually a species complex. Highly plastic morphology and a general lack of defining structures has contributed to the likely underestimate of biodiversity within this group. Molecular methods are a logical next step in the description of these...
Authors
Jacob L. Gregg, Paul Hershberger, Abigail S. Neat, Hiruni T. Jayasekera, Jayde A. Ferguson, Rachel L. Powers, Maureen K. Purcell
Non-USGS Publications**
Purcell, M., G. Mackey, E. LaHood, H. Huber, and L. Park. 2004. Molecular methods for the genetic identification of salmonid prey from Pacific harbor seal (Phoca vitulina richardsi ) scat. Fish. Bull. 1002: 213-220.
Lage, C., M. Purcell, M. Forgarty, and I. Kornfield. 2001. Microsatellite evaluation of haddock (Melanogrammus aeglefinus) stocks in the northwest Atlantic Ocean. Can. J. Fish. Aquat. Sci. 58: 982-990. DOI: 10.1139/cjfas-58-5-982.
Purcell, M.K., J-L. Mu, D.C. Higgins, R. Elango, H. Whitmore, S. Harris, and B. Paigen. 2001. Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Mammalian Genome 12(7): 495-500. DOI: 10.1007/s00335001-0006-9.
Purcell, M.K., I.L. Kornfield, M.J. Fogarty and A. Parker. (1996) Interdecadal heterogeneity of mitochondrial DNA in Atlantic haddock (Melanogrammus aeglefinus) from Georges Bank. Molecular Marine Biology and Biotechnology. 5:185-192.
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
Science and Products
Filter Total Items: 14
AquaDePTH-Aquatic Disease and Pathogen Repository
The Aquatic Disease and Pathogen Repository (AquaDePTH) will be a public-facing national repository to support biosurveillance of aquatic animal diseases and pathogens. By collating historically published data, plus new aquatic pathogen and disease information, stakeholders will be able monitor fish kill and aquatic pathogen trends spatially and temporally in freshwater and marine environments...
Partners - FHP
For more than five decades the WFRC Fish Health Program has worked with partners to provide research findings to managers of aquatic resources. Those partners form a network of colleagues, co-investigators, and customers. Our partners include Department of the Interior bureaus, tribal and state fisheries agencies, other federal partners and the private sector.
Fish Health Program Lead Scientists and Areas of Expertise
Lead Scientists - Expertise
Species Studied by the Fish Health Program
List of species studied by the Fish Health Program. These species include bacteria, fish, parasites, and viruses. The list contains both common and scientific names. Descriptions of species and studies can be found under the "Related Science" tab.
Tribal Collaboration - Fish Health Program (FHP)
The Fish Health Program has a strong commitment to respond to requests for research and technical support from Tribal fisheries agencies.
Herring Disease Program
Using an approach that involves a combination of field- and laboratory-based studies, we are investigating fish health factors that may be contributing to the failed recovery of Pacific herring populations in Prince William Sound, AK. Field studies are providing infection and disease prevalence data to inform the population models, serological data that indicate the prior exposure history and...
Entry and spread of specialist and generalist infectious hematopoietic necrosis virus (IHNV) genotypes in Chinook salmon, steelhead and sockeye salmon Entry and spread of specialist and generalist infectious hematopoietic necrosis virus (IHNV) genotypes in Chinook salmon, steelhead and sockeye salmon
Infectious hematopoietic necrosis virus (IHNV) represents one of the most critical challenges for salmonids in the Pacific Northwest. There are three genogroups of IHNV, designated U, M, and L; the U is further delineated into two subgroups, UC and UP, and the M is further delineated into four subgroups (MA – MD). The UP, UC and MD subgroups co-occur in the Columbia River Basin where the...
Detections, Physical Captures, Water Quality, and Fish Health associated with Endangered Suckers in Three Net Pens in Upper Klamath Lake, 2020 Detections, Physical Captures, Water Quality, and Fish Health associated with Endangered Suckers in Three Net Pens in Upper Klamath Lake, 2020
To determine how initial length affects survival of captively-reared juvenile suckers, we introduced Passive Integrated Transponder (PIT) tagged juvenile suckers into three net pens in Upper Klamath Lake. The suckers originated from the U.S. Fish and Wildlife Service's Sucker Assisted Rearing Program in Klamath Falls, Oregon, which rears suckers collected as larvae in Upper Klamath Lake...
Analytical and diagnostic validation of a molecular test to detect and discriminate IHNV genogroups U and M Analytical and diagnostic validation of a molecular test to detect and discriminate IHNV genogroups U and M
Infectious hematopoietic necrosis virus (IHNV) is an acute pathogen of salmonids in North America, Europe and Asia that is phylogenetically classified into five major virus genogroups (U, M, L, E and J). The geographic range of the U and M genogroup isolates overlap in the North American Columbia River Basin and Washington Coast region, where these genogroups pose different risks...
Histological and molecular testing of nuclear inclusion X in Pacific Razor clams from select locations in Washington, USA Histological and molecular testing of nuclear inclusion X in Pacific Razor clams from select locations in Washington, USA
Nuclear inclusion X (NIX), the etiological agent of bacterial gill disease in Pacific razor clams (Siliqua patula) was associated with host mortality events in coastal Washington, USA during the mid-1980s. Ongoing observations of truncated razor clam size distributions in Kalaloch Beach, Washington raised concerns that NIX continues to impact populations. We conducted a series of spatial...
Spatial and temporal survey of waterborne myxozoan parasites in the Lake Sammamish watershed, Washington, from 2019 - 2021 Spatial and temporal survey of waterborne myxozoan parasites in the Lake Sammamish watershed, Washington, from 2019 - 2021
There is a fundamental knowledge gap on the distribution, prevalence, intensity, and ecology of salmonid myxozoan parasites in the Lake Sammamish watershed, Washington. To address this knowledge gap, we tested water samples for Ceratonova shasta, Parvicapsula minibicornis and Tetracapsuloides bryosalmonae DNA from 84 sites distributed throughout the Lake Sammamish watershed in fall 2019...
Survival, viral load and neutralizing antibodies in steelhead trout and cell cultures exposed to infectious hematopoietic necrosis virus (IHNV) at 3 temperatures Survival, viral load and neutralizing antibodies in steelhead trout and cell cultures exposed to infectious hematopoietic necrosis virus (IHNV) at 3 temperatures
Environmental variation has important effects on host-pathogen interactions, affecting large-scale ecological processes such as the severity and frequency of epidemics. However, less is known about how the environment modulates viral fitness traits and within host infection processes. Viral genetic variation, fish host immune response and environmental parameters such as temperature have...
Filter Total Items: 88
Safety and immunogenicity of poultry vaccine for protecting critically endangered avian species against highly pathogenic avian influenza virus, United States Safety and immunogenicity of poultry vaccine for protecting critically endangered avian species against highly pathogenic avian influenza virus, United States
In 2023, an outbreak of highly pathogenic avian influenza occurred among critically endangered California condors (Gymnogyps californianus), and >21 died. We evaluated safety, immunogenicity, vaccination strategies, and correlates of antibody response of an influenza vaccine for poultry in black vultures (Coragyps atratus) and then California condors. We noted differences in antibody...
Authors
Todd E. Katzner, Ashleigh V. Blackford, Mary Donahue, Samantha E.J. Gibbs, Julianna B. Lenoch, Michael K. Martin, Tonie E. Rocke, J. Jeffrey Root, Darren Styles, Sunny Cooper, Kristin Dean, Zachary Dvornicky-Raymond, Dominique Keller, Carlos Sanchez, Brett Dunlap, Thomas Grier, Michael P. Jones, Gregory Nitzel, Erin Patrick, Maureen Purcell, Aaron J. Specht, David L. Suarez
Genome-wide association analysis of the resistance to infectious hematopoietic necrosis virus in two rainbow trout aquaculture lines confirms oligogenic architecture with several moderate effect quantitative trait loci Genome-wide association analysis of the resistance to infectious hematopoietic necrosis virus in two rainbow trout aquaculture lines confirms oligogenic architecture with several moderate effect quantitative trait loci
Infectious hematopoietic necrosis (IHN) is a disease of salmonid fish that is caused by the IHN virus (IHNV), which can cause substantial mortality and economic losses in rainbow trout aquaculture and fisheries enhancement hatchery programs. In a previous study on a commercial rainbow trout breeding line that has undergone selection, we found that genetic resistance to IHNV is controlled...
Authors
Yniv Palti, Roger L. Vallejo, Maureen K. Purcell, Guangtu Gao, Kristy L. Shewbridge, Roseanna L. Long, Christopher Setzke, Breno O. Fragomeni, Hao Cheng, Kyle E. Martin, Kerrry A. Naish
Local and systemic replicative fitness for viruses in specialist, generalist, and non-specialist interactions with salmonid hosts Local and systemic replicative fitness for viruses in specialist, generalist, and non-specialist interactions with salmonid hosts
Host tissues represent diverse resources or barriers for pathogen replicative fitness. We tested whether viruses in specialist, generalist, and non-specialist interactions replicate differently in local entry tissue (fin), and systemic target tissue (kidney) using infectious hematopoietic necrosis virus (IHNV) and three salmonid fish hosts. Virus tissue replication was host specific, but...
Authors
David James Paez, Gael Kurath, Rachel L. Powers, Kerry A. Naish, Maureen K. Purcell
Evaluating the effect of nuclear inclusion X (NIX) infections on Pacific razor clam populations Evaluating the effect of nuclear inclusion X (NIX) infections on Pacific razor clam populations
ABSTRACT: Nuclear inclusion X (NIX), the etiological agent of bacterial gill disease in Pacific razor clams Siliqua patula, was associated with host mortality events in coastal Washington State, USA, during the mid-1980s. Ongoing observations of truncated razor clam size distributions in Kalaloch Beach, Washington, raised concerns that NIX continues to impact populations. We conducted a...
Authors
Maya Groner, Paul Hershberger, Steven C. Fradkin, Carla M. Conway, Aine C. Hawthorn, Maureen K. Purcell
Variation in within-host replication kinetics among virus genotypes provides evidence of specialist and generalist infection strategies across three salmonid host species Variation in within-host replication kinetics among virus genotypes provides evidence of specialist and generalist infection strategies across three salmonid host species
Theory of the evolution of pathogen specialization suggests that a specialist pathogen gains high fitness in one host, but this comes with fitness loss in other hosts. By contrast, a generalist pathogen does not achieve high fitness in any host, but gains ecological fitness by exploiting different hosts, and has higher fitness than specialists in nonspecialized hosts. As a result...
Authors
David James Paez, Douglas G. McKenney, Maureen K. Purcell, Kerry A. Naish, Gael Kurath
A phylogeny based on cytochrome-c oxidase gene sequences identifies sympatric Ichthyophonus genotypes in the NE Pacific Ocean A phylogeny based on cytochrome-c oxidase gene sequences identifies sympatric Ichthyophonus genotypes in the NE Pacific Ocean
ABSTRACT: In recent decades, evidence has accumulated to suggest that the widespread and highly variable parasite Ichthyophonus hoferi is actually a species complex. Highly plastic morphology and a general lack of defining structures has contributed to the likely underestimate of biodiversity within this group. Molecular methods are a logical next step in the description of these...
Authors
Jacob L. Gregg, Paul Hershberger, Abigail S. Neat, Hiruni T. Jayasekera, Jayde A. Ferguson, Rachel L. Powers, Maureen K. Purcell
Non-USGS Publications**
Purcell, M., G. Mackey, E. LaHood, H. Huber, and L. Park. 2004. Molecular methods for the genetic identification of salmonid prey from Pacific harbor seal (Phoca vitulina richardsi ) scat. Fish. Bull. 1002: 213-220.
Lage, C., M. Purcell, M. Forgarty, and I. Kornfield. 2001. Microsatellite evaluation of haddock (Melanogrammus aeglefinus) stocks in the northwest Atlantic Ocean. Can. J. Fish. Aquat. Sci. 58: 982-990. DOI: 10.1139/cjfas-58-5-982.
Purcell, M.K., J-L. Mu, D.C. Higgins, R. Elango, H. Whitmore, S. Harris, and B. Paigen. 2001. Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in mice. Mammalian Genome 12(7): 495-500. DOI: 10.1007/s00335001-0006-9.
Purcell, M.K., I.L. Kornfield, M.J. Fogarty and A. Parker. (1996) Interdecadal heterogeneity of mitochondrial DNA in Atlantic haddock (Melanogrammus aeglefinus) from Georges Bank. Molecular Marine Biology and Biotechnology. 5:185-192.
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
*Disclaimer: Listing outside positions with professional scientific organizations on this Staff Profile are for informational purposes only and do not constitute an endorsement of those professional scientific organizations or their activities by the USGS, Department of the Interior, or U.S. Government