Tonie Rocke
Tonie Rocke is a Research Epidemiologist at the National Wildlife Health Center.
Science and Products
Filter Total Items: 14
No Result Found
Filter Total Items: 130
Burrow dusting or oral vaccination prevents plague-associated prairie dog colony collapse
Plague impacts prairie dogs (Cynomys spp.), the endangered black-footed ferret (Mustela nigripes) and other sensitive wildlife species. We compared efficacy of prophylactic treatments (burrow dusting with deltamethrin or oral vaccination with recombinant “sylvatic plague vaccine” [RCN-F1/V307]) to placebo treatment in black-tailed prairie dog (C. ludovicianus) colonies. Between 2013 and 2015, we m
Authors
Daniel W. Tripp, Tonie E. Rocke, Jonathan P. Runge, Rachel C. Abbott, Michael W. Miller
Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.)
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, a
Authors
Elizabeth Falendysz, Juan G. Lopera, Jeffrey B. Doty, Yoshinori J. Nakazawa, Colleen Crill, Faye Lorenzsonn, Lem's N. Kalemba, Monica Ronderos, Andres Meija, Jean M. Malekani, Kevin L. Karem, Darrin Caroll, Jorge E. Osorio, Tonie E. Rocke
Sylvatic plague vaccine partially protects prairie dogs (Cynomys spp.) in field trials
Sylvatic plague, caused by Yersinia pestis, frequently afflicts prairie dogs (Cynomys spp.), causing population declines and local extirpations. We tested the effectiveness of bait-delivered sylvatic plague vaccine (SPV) in prairie dog colonies on 29 paired placebo and treatment plots (1–59 ha in size; average 16.9 ha) in 7 western states from 2013 to 2015. We compared relative abundance (using ca
Authors
Tonie E. Rocke, Daniel W. Tripp, Robin E. Russell, Rachel C. Abbott, Katherine Richgels, Marc R. Matchett, Dean E. Biggins, Randall Griebel, Greg Schroeder, Shaun M. Grassel, David R. Pipkin, Jennifer Cordova, Adam Kavalunas, Brian Maxfield, Jesse T. Boulerice, Michael W. Miller
Responses of juvenile black-tailed prairie dogs (Cynomys ludovicianus) to a commercially produced oral plague vaccine delivered at two doses
We confirmed safety and immunogenicity of mass-produced vaccine baits carrying an experimental, commercial-source plague vaccine (RCN-F1/V307) expressing Yersinia pestis V and F1 antigens. Forty-five juvenile black-tailed prairie dogs (Cynomys ludovicianus) were randomly divided into three treatment groups (n=15 animals/group). Animals in the first group received one standard-dose vaccine bait (5×
Authors
Elsa M. Cárdenas-Canales, Lisa L. Wolfe, Tripp. Daniel W., Tonie E. Rocke, Rachel C. Abbott, Michael W. Miller
Infectivity of attenuated poxvirus vaccine vectors and immunogenicity of a raccoonpox vectored rabies vaccine in the Brazilian Free-tailed bat (Tadarida brasiliensis)
Bats (Order Chiroptera) are an abundant group of mammals with tremendous ecological value as insectivores and plant dispersers, but their role as reservoirs of zoonotic diseases has received more attention in the last decade. With the goal of managing disease in free-ranging bats, we tested modified vaccinia Ankara (MVA) and raccoon poxvirus (RCN) as potential vaccine vectors in the Brazilian Free
Authors
Benjamin Stading, Jorge E. Osorio, Andres Velasco-Villa, Michael Smotherman, Brock Kingstad-Bakke, Tonie E. Rocke
Genetic variation at the MHC DRB1 locus is similar across Gunnison's prairie dog (Cynomys gunnisoni) colonies regardless of plague history
Yersinia pestis was introduced to North America around 1900 and leads to nearly 100% mortality in prairie dog (Cynomys spp.) colonies during epizootic events, which suggests this pathogen may exert a strong selective force. We characterized genetic diversity at an MHC class II locus (DRB1) in Gunnison's prairie dog (C. gunnisoni) and quantified population genetic structure at the DRB1versus 12 mic
Authors
Kacy R. Cobble, Katy J. Califf, Nathan E. Stone, Megan M. Shuey, Dawn Birdsell, Rebecca E. Colman, James M. Schupp, Maliha Aziz, Roger Van Andel, Tonie E. Rocke, David M. Wagner, Joseph D. Busch
Evaluation of Yersinia pestis transmission pathways for sylvatic plague in prairie dog populations in the western U.S.
Sylvatic plague, caused by the bacterium Yersinia pestis, is periodically responsible for large die-offs in rodent populations that can spillover and cause human mortalities. In the western US, prairie dog populations experience nearly 100% mortality during plague outbreaks, suggesting that multiple transmission pathways combine to amplify plague dynamics. Several alternate pathways in addition to
Authors
Katherine L. D. Richgels, Robin E. Russell, Gebbiena Bron, Tonie E. Rocke
VNTR diversity in Yersinia pestis isolates from an animal challenge study reveals the potential for in vitro mutations during laboratory cultivation
Underlying mutation rates and other evolutionary forces shape the population structure of bacteria in nature. Although easily overlooked, similar forces are at work in the laboratory and may influence observed mutations. Here, we investigated tissue samples and Yersinia pestis isolates from a rodent laboratory challenge with strain CO92 using whole genome sequencing and multi-locus variable-number
Authors
Amy J. Vogler, Roxanne Nottingham, Joseph D. Busch, Jason W. Sahl, Megan M. Shuey, Jeffrey T. Foster, James M. Schupp, Susan Smith, Tonie E. Rocke, Paul Klein, David M. Wagner
Further assessment of Monkeypox Virus infection in Gambian pouched rats (Cricetomys gambianus) using in vivo bioluminescent imaging
Monkeypox is a zoonosis clinically similar to smallpox in humans. Recent evidence has shown a potential risk of increased incidence in central Africa. Despite attempts to isolate the virus from wild rodents and other small mammals, no reservoir host has been identified. In 2003,Monkeypox virus (MPXV) was accidentally introduced into the U.S. via the pet trade and was associated with the Gambian po
Authors
Elizabeth Falendysz, Juan G. Lopera, Faye Lorenzsonn, Johanna S. Salzer, Christina L. Hutson, Jeffrey Doty, Nadia Gallardo-Romero, Darin S. Carroll, Jorge E. Osorio, Tonie E. Rocke
Laboratory investigations of African Pouched Rats (Cricetomys gambianus) as a potential reservoir host species for Monkeypox Virus
Monkeypox is a zoonotic disease endemic to central and western Africa, where it is a major public health concern. Although Monkeypox virus (MPXV) and monkeypox disease in humans have been well characterized, little is known about its natural history, or its maintenance in animal populations of sylvatic reservoir(s). In 2003, several species of rodents imported from Ghana were involved in a monkeyp
Authors
Christina L. Hutson, Yoshinori J. Nakazawa, Joshua Self, Victoria A. Olson, Russell L. Regnery, Zachary Braden, Sonja Weiss, Jean Malekani, Eddie Jackson, Mallory Tate, Kevin L. Karem, Tonie E. Rocke, Jorge E. Osorio, Inger K. Damon, Darin S. Carroll
Apparent field safety of a raccoon poxvirus-vectored plague vaccine in free-ranging prairie dogs (Cynomys spp.), Colorado, USA
Prairie dogs (Cynomys spp.) suffer high rates of mortality from plague. An oral sylvatic plague vaccine using the raccoon poxvirus vector (designated RCN-F1/V307) has been developed for prairie dogs. This vaccine is incorporated into palatable bait along with rhodamine B as a biomarker. We conducted trials in August and September 2012 to demonstrate uptake and apparent safety of the RCN-F1/V307 va
Authors
Daniel W. Tripp, Tonie E. Rocke, Sean P. Streich, Rachel C. Abbott, Jorge E. Osorio, Michael W. Miller
Age at vaccination may influence response to sylvatic plague vaccine (SPV) in Gunnison’s prairie dogs (Cynomys gunnisoni)
Gunnison’s prairie dogs (Cynomys gunnisoni) have been considered at greater risk from Yersinia pestis (plague) infection in the montane portion of their range compared to populations at lower elevations, possibly due to factors related to flea transmission of the bacteria or greater host susceptibility. To test the latter hypothesis and determine whether vaccination against plague with an oral syl
Authors
Tonie E. Rocke, Daniel W. Tripp, Faye Lorenzsonn, Elizabeth A. Falendysz, Susan Smith, Judy L. Williamson, Rachel C. Abbott
Science and Products
Filter Total Items: 14
No Result Found
Filter Total Items: 130
Burrow dusting or oral vaccination prevents plague-associated prairie dog colony collapse
Plague impacts prairie dogs (Cynomys spp.), the endangered black-footed ferret (Mustela nigripes) and other sensitive wildlife species. We compared efficacy of prophylactic treatments (burrow dusting with deltamethrin or oral vaccination with recombinant “sylvatic plague vaccine” [RCN-F1/V307]) to placebo treatment in black-tailed prairie dog (C. ludovicianus) colonies. Between 2013 and 2015, we m
Authors
Daniel W. Tripp, Tonie E. Rocke, Jonathan P. Runge, Rachel C. Abbott, Michael W. Miller
Characterization of Monkeypox virus infection in African rope squirrels (Funisciurus sp.)
Monkeypox (MPX) is a zoonotic disease endemic in Central and West Africa and is caused by Monkeypox virus (MPXV), the most virulent Orthopoxvirus affecting humans since the eradication of Variola virus (VARV). Many aspects of the MPXV transmission cycle, including the natural host of the virus, remain unknown. African rope squirrels (Funisciurus spp.) are considered potential reservoirs of MPXV, a
Authors
Elizabeth Falendysz, Juan G. Lopera, Jeffrey B. Doty, Yoshinori J. Nakazawa, Colleen Crill, Faye Lorenzsonn, Lem's N. Kalemba, Monica Ronderos, Andres Meija, Jean M. Malekani, Kevin L. Karem, Darrin Caroll, Jorge E. Osorio, Tonie E. Rocke
Sylvatic plague vaccine partially protects prairie dogs (Cynomys spp.) in field trials
Sylvatic plague, caused by Yersinia pestis, frequently afflicts prairie dogs (Cynomys spp.), causing population declines and local extirpations. We tested the effectiveness of bait-delivered sylvatic plague vaccine (SPV) in prairie dog colonies on 29 paired placebo and treatment plots (1–59 ha in size; average 16.9 ha) in 7 western states from 2013 to 2015. We compared relative abundance (using ca
Authors
Tonie E. Rocke, Daniel W. Tripp, Robin E. Russell, Rachel C. Abbott, Katherine Richgels, Marc R. Matchett, Dean E. Biggins, Randall Griebel, Greg Schroeder, Shaun M. Grassel, David R. Pipkin, Jennifer Cordova, Adam Kavalunas, Brian Maxfield, Jesse T. Boulerice, Michael W. Miller
Responses of juvenile black-tailed prairie dogs (Cynomys ludovicianus) to a commercially produced oral plague vaccine delivered at two doses
We confirmed safety and immunogenicity of mass-produced vaccine baits carrying an experimental, commercial-source plague vaccine (RCN-F1/V307) expressing Yersinia pestis V and F1 antigens. Forty-five juvenile black-tailed prairie dogs (Cynomys ludovicianus) were randomly divided into three treatment groups (n=15 animals/group). Animals in the first group received one standard-dose vaccine bait (5×
Authors
Elsa M. Cárdenas-Canales, Lisa L. Wolfe, Tripp. Daniel W., Tonie E. Rocke, Rachel C. Abbott, Michael W. Miller
Infectivity of attenuated poxvirus vaccine vectors and immunogenicity of a raccoonpox vectored rabies vaccine in the Brazilian Free-tailed bat (Tadarida brasiliensis)
Bats (Order Chiroptera) are an abundant group of mammals with tremendous ecological value as insectivores and plant dispersers, but their role as reservoirs of zoonotic diseases has received more attention in the last decade. With the goal of managing disease in free-ranging bats, we tested modified vaccinia Ankara (MVA) and raccoon poxvirus (RCN) as potential vaccine vectors in the Brazilian Free
Authors
Benjamin Stading, Jorge E. Osorio, Andres Velasco-Villa, Michael Smotherman, Brock Kingstad-Bakke, Tonie E. Rocke
Genetic variation at the MHC DRB1 locus is similar across Gunnison's prairie dog (Cynomys gunnisoni) colonies regardless of plague history
Yersinia pestis was introduced to North America around 1900 and leads to nearly 100% mortality in prairie dog (Cynomys spp.) colonies during epizootic events, which suggests this pathogen may exert a strong selective force. We characterized genetic diversity at an MHC class II locus (DRB1) in Gunnison's prairie dog (C. gunnisoni) and quantified population genetic structure at the DRB1versus 12 mic
Authors
Kacy R. Cobble, Katy J. Califf, Nathan E. Stone, Megan M. Shuey, Dawn Birdsell, Rebecca E. Colman, James M. Schupp, Maliha Aziz, Roger Van Andel, Tonie E. Rocke, David M. Wagner, Joseph D. Busch
Evaluation of Yersinia pestis transmission pathways for sylvatic plague in prairie dog populations in the western U.S.
Sylvatic plague, caused by the bacterium Yersinia pestis, is periodically responsible for large die-offs in rodent populations that can spillover and cause human mortalities. In the western US, prairie dog populations experience nearly 100% mortality during plague outbreaks, suggesting that multiple transmission pathways combine to amplify plague dynamics. Several alternate pathways in addition to
Authors
Katherine L. D. Richgels, Robin E. Russell, Gebbiena Bron, Tonie E. Rocke
VNTR diversity in Yersinia pestis isolates from an animal challenge study reveals the potential for in vitro mutations during laboratory cultivation
Underlying mutation rates and other evolutionary forces shape the population structure of bacteria in nature. Although easily overlooked, similar forces are at work in the laboratory and may influence observed mutations. Here, we investigated tissue samples and Yersinia pestis isolates from a rodent laboratory challenge with strain CO92 using whole genome sequencing and multi-locus variable-number
Authors
Amy J. Vogler, Roxanne Nottingham, Joseph D. Busch, Jason W. Sahl, Megan M. Shuey, Jeffrey T. Foster, James M. Schupp, Susan Smith, Tonie E. Rocke, Paul Klein, David M. Wagner
Further assessment of Monkeypox Virus infection in Gambian pouched rats (Cricetomys gambianus) using in vivo bioluminescent imaging
Monkeypox is a zoonosis clinically similar to smallpox in humans. Recent evidence has shown a potential risk of increased incidence in central Africa. Despite attempts to isolate the virus from wild rodents and other small mammals, no reservoir host has been identified. In 2003,Monkeypox virus (MPXV) was accidentally introduced into the U.S. via the pet trade and was associated with the Gambian po
Authors
Elizabeth Falendysz, Juan G. Lopera, Faye Lorenzsonn, Johanna S. Salzer, Christina L. Hutson, Jeffrey Doty, Nadia Gallardo-Romero, Darin S. Carroll, Jorge E. Osorio, Tonie E. Rocke
Laboratory investigations of African Pouched Rats (Cricetomys gambianus) as a potential reservoir host species for Monkeypox Virus
Monkeypox is a zoonotic disease endemic to central and western Africa, where it is a major public health concern. Although Monkeypox virus (MPXV) and monkeypox disease in humans have been well characterized, little is known about its natural history, or its maintenance in animal populations of sylvatic reservoir(s). In 2003, several species of rodents imported from Ghana were involved in a monkeyp
Authors
Christina L. Hutson, Yoshinori J. Nakazawa, Joshua Self, Victoria A. Olson, Russell L. Regnery, Zachary Braden, Sonja Weiss, Jean Malekani, Eddie Jackson, Mallory Tate, Kevin L. Karem, Tonie E. Rocke, Jorge E. Osorio, Inger K. Damon, Darin S. Carroll
Apparent field safety of a raccoon poxvirus-vectored plague vaccine in free-ranging prairie dogs (Cynomys spp.), Colorado, USA
Prairie dogs (Cynomys spp.) suffer high rates of mortality from plague. An oral sylvatic plague vaccine using the raccoon poxvirus vector (designated RCN-F1/V307) has been developed for prairie dogs. This vaccine is incorporated into palatable bait along with rhodamine B as a biomarker. We conducted trials in August and September 2012 to demonstrate uptake and apparent safety of the RCN-F1/V307 va
Authors
Daniel W. Tripp, Tonie E. Rocke, Sean P. Streich, Rachel C. Abbott, Jorge E. Osorio, Michael W. Miller
Age at vaccination may influence response to sylvatic plague vaccine (SPV) in Gunnison’s prairie dogs (Cynomys gunnisoni)
Gunnison’s prairie dogs (Cynomys gunnisoni) have been considered at greater risk from Yersinia pestis (plague) infection in the montane portion of their range compared to populations at lower elevations, possibly due to factors related to flea transmission of the bacteria or greater host susceptibility. To test the latter hypothesis and determine whether vaccination against plague with an oral syl
Authors
Tonie E. Rocke, Daniel W. Tripp, Faye Lorenzsonn, Elizabeth A. Falendysz, Susan Smith, Judy L. Williamson, Rachel C. Abbott