This dataset captures the Zebra Mussel dose-response to four independent toxicants and each binary mixture of those toxicants. Toxicants included EarthTec QZ, Clam-Trol CT-2 (syn. Spectrus CT1300), niclosamide, and potassium chloride. Each dose of toxicant was verified with either ICP-OES or UHPLC, depending on analyte, and comparison to a standard curve. Mortality was tabulated for each observation.