These data are comprised of measurements of aluminum, iron, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, silver, cadmium, thallium, lead, bismuth, thorium, uranium, and mercury in soil, vegetation, and small rodents. Gross alpha activity, gross beta activity, and radionuclide activities (isotopic U, isotopic Th) are also presented for vegetation and soil. Radioactivities for small rodents were previously presented at https://doi.org/10.5066/P9HARTQ4. The data also include histopathological analysis of liver tissues collected from small rodents. Samples were collected at the Kanab North Mine and Canyon Mine (post-mining, pre-reclamation) in the Grand Canyon watershed.