This data release contains measured stream discharge and total dissolved solids (TDS) data and estimated values for daily stream TDS loads, daily baseflow discharge, and daily baseflow TDS loads for 205 locations in the Upper Colorado River Basin. The estimated values, which represent conditions between 10/1/1985 and 9/30/2020, were obtained using the Weighted Regressions on Time, Discharge, and Season (WRTDS) program and a previously published method for hydrograph separation.