Hepatic Transcriptome of Japanese quail (Coturnix japonica) Exposed to 17B.-Trenbolone
The files in this data release are RNA seq datafiles from a study that examined the effects of the synthetic anabolic steroid 17B. hydroxyestra 4,9,11 trien-3-one, trenbolone (17B.T - CAS 10161-33-8), a common contaminant of wastes from confined animal feeding operations (CAFOs). Japanese quail (Coturnix japonica) were exposed in the egg and through feed to multiple doses of 17βT and liver transcriptomes were examined to identify genes and pathways directly affected by this androgenic compound. RNA was extracted from liver of adults and embryos and analyzed (1x50 bp) on an Illumina HiSeq 2000. NCBI Biosample accessions and the raw counts that were input into the differential expression analysis are provided in this dataset. The raw sequence data are available at the NCBI Sequence Read Archive under Bioproject numbers PRJNA313918 and PRJNA313931.
Citation Information
| Publication Year | 2021 |
|---|---|
| Title | Hepatic Transcriptome of Japanese quail (Coturnix japonica) Exposed to 17B.-Trenbolone |
| DOI | 10.5066/P9M4JOOV |
| Authors | Natalie K Karouna, Robert S Cornman |
| Product Type | Data Release |
| Record Source | USGS Digital Object Identifier Catalog |
| USGS Organization | Eastern Ecological Science Center at the Leetown Research Laboratory |
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Sex- and developmental stage-related differences in the hepatic transcriptome of Japanese quail (Coturnix japonica) exposed to 17β-Trenbolone
Endocrine-disrupting chemicals can cause transcriptomic changes that may disrupt biological processes associated with reproductive function including metabolism, transport, and cell growth. We investigated effects from in ovo and dietary exposure to 17β-trenbolone (at 0, 1, and 10 ppm) on the Japanese quail (Coturnix japonica) hepatic transcriptome. Our objectives were to identify differentially eAuthorsKrittika Mittal, Paula F. P. Henry, Robert S. Cornman, Catherine M. Maddox, Niladri Basu, Natalie K. Karouna-Renier - Connect