This USGS Data Release represents water and sediment quality data collected in the Grand Canyon region of northern Arizona. There are 3 separate datasets associated with this Data Release: Water and sediment quality data from major Colorado River tributary monitoring sites in and near Grand Canyon from 2015 through 2019. Water quality results from spring and stream sites in Grand Canyon that were sampled by U.S. National Park Service personnel in 2016 and 2017. Time series water quality results from select spring sites in Grand Canyon that were sampled using a Minisipper autosampler. Filtered water samples were analyzed using inductively coupled plasma - mass spectrometry (ICP-MS). Sediment samples were first decomposed using a mixture of hydrochloric, nitric, perchloric, and hydrofluoric acids at low temperature. The resulting solution was analyzed by ICP optical emission spectrometry (OES) and ICP-MS.