In Response: Biological arguments for selecting effect sizes in ecotoxicological testing—A governmental perspective
October 31, 2015
Criticisms of the uses of the no-observed-effect concentration (NOEC) and the lowest-observed-effect concentration (LOEC) and more generally the entire null hypothesis statistical testing scheme are hardly new or unique to the field of ecotoxicology [1-4]. Among the criticisms of NOECs and LOECs is that statistically similar LOECs (in terms of p value) can represent drastically different levels of effect. For instance, my colleagues and I found that a battery of chronic toxicity tests with different species and endpoints yielded LOECs with minimum detectable differences ranging from 3% to 48% reductions from controls [5].
Citation Information
Publication Year | 2015 |
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Title | In Response: Biological arguments for selecting effect sizes in ecotoxicological testing—A governmental perspective |
DOI | 10.1002/etc.3108 |
Authors | Christopher A. Mebane |
Publication Type | Article |
Publication Subtype | Journal Article |
Series Title | Environmental Toxicology and Chemistry |
Index ID | 70169071 |
Record Source | USGS Publications Warehouse |
USGS Organization | Idaho Water Science Center |