Donald Tillitt, PhD (Former Employee)

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February 8, 2019

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...

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Ecosystems Mission Area, Species Management Research Program, Columbia Environmental Research Center

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

February 8, 2019

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...

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July 5, 2016

Adverse reproductive and developmental health outcomes following prenatal exposure to a 2 hydraulic fracturing chemical mixture in female C57Bl/6 mice Adverse reproductive and developmental health outcomes following prenatal exposure to a 2 hydraulic fracturing chemical mixture in female C57Bl/6 mice

Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly used hydraulic fracturing chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors in a human endometrial cancer cell reporter gene assay and...

Authors

Christopher D. Kassotis, John J. Bromfield, Kara C. Klemp, Chun-Xia Meng, Andrew R. Wolfe, Thomas Zoeller, Victoria D. Balise, Chiamaka J. Isiguzo, Donald E. Tillitt, Susan C. Nagel

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

October 14, 2015

Endocrine-disrupting activity of hydraulic fracturing chemicals and adverse health outcomes after prenatal exposure in male mice Endocrine-disrupting activity of hydraulic fracturing chemicals and adverse health outcomes after prenatal exposure in male mice

Oil and natural gas operations have been shown to contaminate surface and ground water with endocrine-disrupting chemicals. In the current study, we fill several gaps in our understanding of the potential environmental impacts related to this process. We measured the endocrine-disrupting activities of 24 chemicals used and/or produced by oil and gas operations for five nuclear receptors...

Authors

Christopher D. Kassotis, Kara C. Klemp, Danh C. Vu, Chung-Ho Lin, Chun-Xia Meng, Cynthia L. Besch-Williford, Lisa Pinatti, R. Thomas Zoeller, Erma Z. Drobnis, Victoria D. Balise, Chiamaka J. Isiguzo, Michelle A. Williams, Donald E. Tillitt, Susan C. Nagel

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

August 27, 2015

Endocrine-disrupting chemicals and oil and natural gas operations: Potential environmental contamination and recommendations to assess complex environmental mixtures Endocrine-disrupting chemicals and oil and natural gas operations: Potential environmental contamination and recommendations to assess complex environmental mixtures

Background: Hydraulic fracturing technologies, developed over the last 65 years, have only recently been combined with horizontal drilling to unlock oil and gas reserves previously deemed inaccessible. While these technologies have dramatically increased domestic oil and natural gas production, they have also raised concerns for the potential contamination of local water supplies with...

Authors

Christopher D. Kassotis, Donald E. Tillitt, Chung-Ho Lin, Jane A. McElroy, Susan C. Nagel

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

June 17, 2015

Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species

Endocrine disrupting chemicals (EDCs), including the mass-produced component of plastics, bisphenol A (BPA) are widely prevalent in aquatic and terrestrial habitats. Many aquatic species, such as fish, amphibians, aquatic reptiles and mammals, are exposed daily to high concentrations of BPA and ethinyl estradiol (EE2), estrogen in birth control pills. In this review, we will...

Authors

Ramji K. Bhandari, Sharon L. Deem, Dawn K. Holliday, Caitlin M. Jandegian, Christopher D. Kassotis, Susan C. Nagel, Donald E. Tillitt, Frederick S. vom Saal, Cheryl S. Rosenfeld

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

April 8, 2015

Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta) Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta)

Environmental chemicals can disrupt endocrine signaling and adversely impact sexual differentiation in wildlife. Bisphenol A (BPA) is an estrogenic chemical commonly found in a variety of habitats. In this study, we used painted turtles (Chrysemys picta), which have temperature-dependent sex determination (TSD), as an animal model for ontogenetic endocrine disruption by BPA. We...

Authors

Caitlin M. Jandegian, Sharon L. Deem, Ramji K. Bhandari, Casey M. Holliday, Diane Nicks, Cheryl S. Rosenfeld, Kyle Selcer, Donald E. Tillitt, Fredrick S. vom Saal, Vanessa Velez, Ying Yang, Dawn K. Holliday

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

April 1, 2015

Characterization of Missouri surface waters near point sources of pollution reveals potential novel atmospheric route of exposure for bisphenol A and wastewater hormonal activity pattern Characterization of Missouri surface waters near point sources of pollution reveals potential novel atmospheric route of exposure for bisphenol A and wastewater hormonal activity pattern

Surface water contamination by chemical pollutants increasingly threatens water quality around the world. Among the many contaminants found in surface water, there is growing concern regarding endocrine disrupting chemicals, based on their ability to interfere with some aspect of hormone action in exposed organisms, including humans. This study assessed water quality at several sites...

Authors

Christopher D. Kassotis, David A. Alvarez, Julia A. Taylor, Frederick S. vom Saal, Susan C. Nagel, Donald E. Tillitt

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

March 25, 2015

Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes Transgenerational effects from early developmental exposures to bisphenol A or 17α-ethinylestradiol in medaka, Oryzias latipes

The transgenerational consequences of environmental contaminant exposures of aquatic vertebrates have the potential for broad ecological impacts, yet are largely uninvestigated. Bisphenol A (BPA) and 17α-ethinylestradiol (EE2) are two ubiquitous estrogenic chemicals present in aquatic environments throughout the United States and many other countries. Aquatic organisms, including fish...

Authors

Ramji K. Bhandari, Frederick S. vom Saal, Donald E. Tillitt

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Chesapeake Bay Activities, Columbia Environmental Research Center

January 1, 2015

Sensitivity of shovelnose sturgeon (Scaphirhynchus platorynchus) and pallid sturgeon (S. albus) early life stages to 3,30,4,40,5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure Sensitivity of shovelnose sturgeon (Scaphirhynchus platorynchus) and pallid sturgeon (S. albus) early life stages to 3,30,4,40,5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure

Concern exists that polychlorinated biphenyls (PCBs) may be contributing to the current decline of shovelnose sturgeon (Scaphirhynchus platorynchus) and the US federally endangered pallid sturgeon (Scaphirhynchus albus). Waterborne exposures with newly fertilized eggs were used to assess developmental and morphological effects of 2 of the most potent aryl hydrocarbon receptor (AhR)...

Authors

Justin Buckler, James S. Candrl, Michael J. McKee, Diana M. Papoulias, Donald E. Tillitt, David L. Galat

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

July 1, 2014

Methylmercury-induced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides) Methylmercury-induced changes in gene transcription associated with neuroendocrine disruption in largemouth bass (Micropterus salmoides)

Methyl-mercury (MeHg) is a potent neuroendocrine disruptor that impairs reproductive processes in fish. The objectives of this study were to (1) characterize transcriptomic changes induced by MeHg exposure in the female largemouth bass (LMB) hypothalamus under controlled laboratory conditions, (2) investigate the health and reproductive impacts of MeHg exposure on male and female...

Authors

Catherine A. Richter, Christopher J. Martyniuk, Mandy L. Annis, William G. Brumbaugh, Lia C. Chasar, Nancy D. Denslow, Donald E. Tillitt

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

June 16, 2014

Atrazine reduces reproduction in Japanese medaka (Oryzias latipes) Atrazine reduces reproduction in Japanese medaka (Oryzias latipes)

Atrazine is an effective broadleaf herbicide and the second most heavily used herbicide in the United States. Effects along the hypothalamus–pituitary–gonad axis in a number of vertebrate taxa have been demonstrated. Seasonally elevated concentrations of atrazine in surface waters may adversely affect fishes, but only a few studies have examined reproductive effects of this chemical. The...

Authors

Diana M. Papoulias, Donald E. Tillitt, Melaniya G. Talykina, Jeffrey J. Whyte, Catherine A. Richter

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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

March 6, 2014

Atrazine reduces reproduction in fathead minnow (Pimephales promelas): raw data report Atrazine reduces reproduction in fathead minnow (Pimephales promelas): raw data report

The herbicide, atrazine, routinely is observed in surface and groundwaters, particularly in the “corn belt” region, a high-use area of the United States. Atrazine has demonstrated effects on reproduction in mammals and amphibians, but the characterization of endocrine-related effects in fish has received only limited attention. Peak concentrations of atrazine in surface water of streams...

Authors

Donald E. Tillitt, Diana M. Papoulias, Jeffrey J. Whyte, Cathy A. Richter

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Ecosystems Mission Area, Columbia Environmental Research Center

March 1, 2014

Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region

The rapid rise in natural gas extraction using hydraulic fracturing increases the potential for contamination of surface and ground water from chemicals used throughout the process. Hundreds of products containing more than 750 chemicals and components are potentially used throughout the extraction process, including more than 100 known or suspected endocrine-disrupting chemicals. We

Authors

Christopher D. Kassotis, Donald E. Tillitt, J. Wade Davis, Anette M. Hormann, Susan C. Nagel

By

Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Columbia Environmental Research Center

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