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Jason T. Magnuson, PhD

Dr. Jason Magnuson is a Research Biologist at the Columbia Environmental Research Center.

Dr. Magnuson researches the influence of environmental contaminants and abiotic stressors on fish health. He uses molecular-level endpoints, such as transcriptomics and metabolomics, to link to higher levels of biological organization, including histopathology, physiology, and behavior, to understand the toxicity of aquatic pollutants to fish. Previous research projects have involved the relationship between mercury and selenium molar ratios to fish stress responses, the impact of pesticides to neuroendocrine, olfactory, swimming performance, and neurotoxic responses to salmonids, the effects of polycyclic aromatic hydrocarbons present in crude oil on early life stage eye development and fish visual function, as well as the toxic response of contaminants when present as a mixture or co-exposed with ultraviolet radiation and temperature. Additionally, current research projects have focused on the impact of pharmaceuticals on early life stage fish development.

Professional Experience

  • 2023 - present, Research Biologist, U.S. Geological Survey, Columbia Environmental Research Center, Columbia, MO

  • 2021-2023, Postdoctoral Fellow, University of Stavanger, Stavanger, Norway

  • 2018-2021, Postdoctoral Fellow, University of California, Riverside, Riverside, CA

Education and Certifications

  • Ph.D. in Biology, University of North Texas, 2018

  • M.S. in Biology with Aquatic Science Concentration, University of Wisconsin-La Crosse, 2015

  • B.S. in Biology and minor in Environmental Science, Lander University, 2013

Science and Products

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Perfluorohexanesulfonic Acid (PFHxS) Dysregulates Lipid Homeostasis in Early Life Stage Fish

A frequently detected perfluorinated compound in the environment, perfluorohexanesulfonic acid (PFHxS), can alter lipid metabolism in developing fish. This work identifies a novel mechanism in which PFHxS targets lipid metabolism pathways by using multiple omic techniques and modeling approaches.
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Columbia Environmental Research Center
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Perfluorohexanesulfonic Acid (PFHxS) Dysregulates Lipid Homeostasis in Early Life Stage Fish

A frequently detected perfluorinated compound in the environment, perfluorohexanesulfonic acid (PFHxS), can alter lipid metabolism in developing fish. This work identifies a novel mechanism in which PFHxS targets lipid metabolism pathways by using multiple omic techniques and modeling approaches.
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Image Collage of Landsat, pollinator, and volcanologist

Gut-Liver Axis: Review on How Microplastics Can Cause Toxicity Through an Interaction Between the Gut, Microbial Community, and Liver

Microplastics can cause liver damage when consumed by terrestrial and aquatic organisms. This review proposes a novel mechanism to help explain the toxic effects following ingestion, which involves the gut, microbial community, and liver through the gut-liver axis.
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Columbia Environmental Research Center
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Gut-Liver Axis: Review on How Microplastics Can Cause Toxicity Through an Interaction Between the Gut, Microbial Community, and Liver

Microplastics can cause liver damage when consumed by terrestrial and aquatic organisms. This review proposes a novel mechanism to help explain the toxic effects following ingestion, which involves the gut, microbial community, and liver through the gut-liver axis.
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Zebrafish (Danio rerio)

Study Finds PFOSA Can Suppress Immune Function in Developing Zebrafish (Danio rerio)

The Stockholm Convention has labeled PFOS a “persistent organic pollutant” due to its long-enduring prevalence, negative toxicological effects, and ability to bioaccumulate in living things. Concerns about PFOSA have been raised due to its similarity to PFOS, its ability to metabolize into PFOS, and its persistent use today
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Columbia Environmental Research Center
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Study Finds PFOSA Can Suppress Immune Function in Developing Zebrafish (Danio rerio)

The Stockholm Convention has labeled PFOS a “persistent organic pollutant” due to its long-enduring prevalence, negative toxicological effects, and ability to bioaccumulate in living things. Concerns about PFOSA have been raised due to its similarity to PFOS, its ability to metabolize into PFOS, and its persistent use today
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Comprehensive Research on PFAS Exposomics and Risk Assessment

The Columbia Environmental Research Center (CERC) conducts cutting-edge research on per- and polyfluoroalkyl substances (PFAS) through the lens of the One Health Paradigm, emphasizing the interconnectedness of human, animal, and environmental health.
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Columbia Environmental Research Center
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Comprehensive Research on PFAS Exposomics and Risk Assessment

The Columbia Environmental Research Center (CERC) conducts cutting-edge research on per- and polyfluoroalkyl substances (PFAS) through the lens of the One Health Paradigm, emphasizing the interconnectedness of human, animal, and environmental health.
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Fishing, Hunting and Subsistence Living Integrated Science Team

The Fishing, Hunting, and Subsistence Living Integrated Science Team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively...
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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Toxic Substances Hydrology
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Fishing, Hunting and Subsistence Living Integrated Science Team

The Fishing, Hunting, and Subsistence Living Integrated Science Team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively...
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Filter Total Items: 15

Abundance of microplastics in a typical urban wetland in China: Association with occurrence and carbon storage

Microplastics (MPs) are gaining attention for their widespread presence and toxicity in ecosystems. However, their role as a carbon source in urban wetland carbon sinks is still unclear. In this study, the microplastic-carbon (MP-C) was firstly quantified based on the abundance and occurrence characteristics, including MP morphology, size and type in the Sanyang Wetland, a typical urban...
Authors
Haowen Zhang, Mengjie Pu, Ming Zheng, Bentuo Xu, Jason Tyler Magnuson, Qiqing Chen, Xiangrong Xu, Xiangyong Zheng, Min Zhao, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Exposure to the Polychlorinated biphenyl mixture Aroclor 1254 elicits neurological and cardiac developmental effects in early life stage zebrafish (Danio rerio)

The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g., fish tissue), the lack of standard exposure methods...
Authors
Corey A. Green, Jeffrey M. Morris, Jason Tyler Magnuson, Rachel Leads, Claire R. Lay, Michel Gielazyn, Lisa Rosman, Daniel Schlenk, Aaron P. Roberts
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Ecosystems Mission Area, Columbia Environmental Research Center

A universal method for the simultaneous determination of environmental pollutants in marine biological samples: Per- and polyfluoroalkyl substances and antibiotics as a case study

Conventional detection technologies for environmental contaminants have primarily focused on providing accurate qualitative and quantitative evaluations for single pollutant types, leading to increased costs and an inability to satisfy the growing demand for detecting a broader spectrum of pollutants. Here, we introduced a novel analytical method to simultaneously measure the...
Authors
Di Fang, Ge Yang, Bentuo Xu, Jialin Li, Jiayi Lin, Chunmiao Zheng, Jason Tyler Magnuson, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Perfluorohexanesulfonic acid (PFHxS) induces hepatotoxicity through the PPAR signaling pathway in larval zebrafish (Danio rerio)

In recent years, the industrial substitution of long-chain per- and polyfluoroalkyl substances (PFAS) with short-chain alternatives has become increasingly prevalent, resulting in the widespread environmental detection of perfluorohexanesulfonic acid (PFHxS), a short-chain PFAS. However, there remains limited information about the potential adverse effects of PFHxS at environmental...
Authors
Haolin Liao, Ying-Jie He, Shuwen Zhang, Xinyuan Kang, Xin Yang, Bentuo Xu, Jason Tyler Magnuson, Shuping Wang, Chunmiao Zheng, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Establishment of a cell culture from Daphnia magna as an in vitro model for (eco)toxicology assays: Case study using Bisphenol A as a representative cytotoxic and endocrine disrupting chemical

Bisphenol A (BPA) is a widely used industrial compound found in polycarbonate plastics, epoxy resin, and various polymer materials, leading to its ubiquitous presence in the environment. The toxicity of BPA to aquatic organisms has been well documented following in vivo exposure scenarios, with known cytotoxic and endocrine-disrupting effects. As such, BPA was used in this study as a...
Authors
Sreevidya CP, Manoj Kumar TM, Soumya Balakrishnana, Suresh Kunjiramana, Manomi Sarasan, Jason Tyler Magnuson, Jayesh Puthumana
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Ecosystems Mission Area, Columbia Environmental Research Center

Immunotoxic response of bio-based plastic on early life stage zebrafish (Danio rerio): A safe alternative to petroleum-based plastics?

Bio-based plastics are marketed as environmentally friendly alternatives to petroleum-based plastics, although they require specific composting conditions for degradation, which leads to their accumulation in the environment and potential risks to aquatic organisms. We hypothesized that the accumulation of bio-based plastics may induce immunotoxic responses in fish. Our research focused...
Authors
Haodong Cheng, Yao Zou, Bin Lu, Jiazhen Wang, Rongrong Xuan, Jason Tyler Magnuson, Chunmiao Zheng, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Perfluorohexanesulfonic acid (PFHxS) impairs lipid homeostasis in zebrafish larvae through activation of PPARα

Perfluorohexanesulfonic acid (PFHxS), an emerging short-chain per- and polyfluoroalkyl substance, has been frequently detected in aquatic environments. Adverse outcome pathway studies have shown that perfluorinated compounds impair lipid homeostasis through peroxisome proliferator activated receptors (PPARs). However, many of these studies were performed at high concentrations and may...
Authors
Ying-Jie He, Haolin Liao, Ge Yang, Wenhui Qui, Rongrong Xuan, Guomao Zheng, Bentuo Xu, Xin Yang, Jason Tyler Magnuson, Daniel Schlenk, Chunmiao Zheng
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Ecosystems Mission Area, Columbia Environmental Research Center

Dopaminergic and anti-estrogenic responses in juvenile steelhead (Oncorhynchus mykiss) exposed to bifenthrin

The frequency of detection and concentrations of bifenthrin, a pyrethroid insecticide, in the waterways inhabited by the endangered species, steelhead trout (Oncorhynchus mykiss), has become a significant concern for regulatory agencies. Endocrine disruption has been observed with estrogenic and anti-estrogenic responses in fish species at different life stages. Since several studies...
Authors
Jason Tyler Magnuson, Nathan D. Sy, Philip Tanabe, Chenyang Ji, Jay Gan, Daniel Schlenk
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Ecosystems Mission Area, Columbia Environmental Research Center

Perfluorooctane sulfonamide induced autotoxic effects on the zebrafish immune system

Perfluorooctane sulfonamide (PFOSA) is an immediate perfluorooctanesulfonate (PFOS) precursor (PreFOS). Previous studies have shown PFOSA to induce stronger toxic responses compared to other perfluorinated compounds (PFCs). However, the specific nature of PFOSA-induced toxicity, whether autonomous or mediated by its metabolite PFOS, has not been fully elucidated. This study...
Authors
Honghong Chen, Yao Zou, Xingyuan Kang, Ge Yang, Xinghe Yang, Yingying Yao, Jason Tyler Magnuson, Xinde Cao, Wenhui Qiu, Elvis Zu Genbo, Chunmiao Zheng
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Ecosystems Mission Area, Columbia Environmental Research Center

The roles of diet and habitat use in pesticide bioaccumulation by juvenile Chinook Salmon: Insights from stable isotopes and fatty acid biomarkers

Stable isotopes (SI) and fatty acid (FA) biomarkers can provide insights regarding trophic pathways and habitats associated with contaminant bioaccumulation. We assessed relationships between SI and FA biomarkers and published data on concentrations of two pesticides [dichlorodiphenyltrichloroethane and degradation products (DDX) and bifenthrin] in juvenile Chinook Salmon (Oncorhynchus...
Authors
Sara E. Anzalone, Neil W. Fuller, Kara E. Huff Hartz, Gregory W. Whitledge, Jason Tyler Magnuson, Daniel Schlenk, Shawn Acuña, Matt R. Whiles, Michael J. Lydy
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Ecosystems Mission Area, Columbia Environmental Research Center

Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis

Microplastics (MPs) are environmental contaminants that are present in all environments and can enter the human body, accumulate in various organs, and cause harm through the ingestion of food, inhalation, and dermal contact. The connection between bowel and liver disease and the interplay between gut, liver, and flora has been conceptualized as the “gut-liver axis”. Microplastics can...
Authors
Xiaomei Wang, Kaili Deng, Pei Zhen Zhang, Qiqing Chen, Jason Tyler Magnuson, Wenhui Qiu, Yuping Zhou
By
Ecosystems Mission Area, Columbia Environmental Research Center

Mixture effects of per- and polyfluoroalkyl substances on embryonic and larval Sheepshead Minnows (Cyprinodon variegatus)

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and persistent environmental contaminants originating from many everyday products. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are two PFAS that are commonly found at high concentrations in aquatic environments. Both chemicals have previously been shown to be toxic to fish, as well as having complex and...
Authors
Philip Tanabe, Peter B. Key, Katy W. Chung, Emily C. Pisarski, Jessica L. Reiner, Rodowa. Alix E., Jason Tyler Magnuson, Marie E. DeLorenzo
By
Ecosystems Mission Area, Columbia Environmental Research Center

Non-USGS Publications**

Tang, L., Qiu, W., Zhang, S., Wang, J., Yang, X., Xu, B., Magnuson, J.T., Xu, E.G., Wu, M., and Zheng, C., 2023, Poly- and perfluoroalkyl substances induce immunotoxicity via the TLR pathway in zebrafish: Links to carbon-chain length: Environmental Science & Technology, v. 57, no. 15, p. 6139-6149. https://doi.org/10.1021/acs.est.2c09716
Magnuson, J.T., and Sandheinrich, M.B., 2023, Relation among mercury, selenium, and
biomarkers of oxidative stress in northern pike (Esox lucius): Toxics, v. 11, no. 3, p. 244.
https://www.mdpi.com/2305-6304/11/3/244
Pampanin, D.M., Arnli, W.B., Magnuson, J.T., Monticelli, G., Dam, M., Mikalsen, S.-O., and Sydnes, M.O., 2023, Study of the long-finned pilot whale (Globicephala melas) bile content - An indicator of ocean health: Marine Pollution Bulletin, v. 189, p. 114795. https://doi.org/10.1016/j.marpolbul.2023.114795
Zhang, S., Zheng, M., Yang, G., Zhang, T., Magnuson, J.T., Chen, H., Zheng, C., and Qiu, W., 2023, Sunlight-mediated CaO2 inactivation of pathogen indicator organisms in surface water system: Roles of reactive species, characterization of pathogen inactivation: Water Research, v. 233, p. 119756. https://doi.org/10.1016/j.watres.2023.119756
Liu, S., Qiu, W., Li, R., Chen, B., Wu, X., Magnuson, J.T., Xu, B., Luo, S., Xu, E.G., and Zheng, C., 2023, Perfluorononanoic acid induces neurotoxicity via synaptogenesis signaling in zebrafish, v. 57, no. 9, p. 3783-3793. https://doi.org/10.1021/acs.est.2c06739
Magnuson, J.T., Fuller, N., McGruer, V., Huff Hartz, K.E., Acuña, S., Whitledge, G.W., Lydy, M.J., and Schlenk, D., 2023, Effect of temperature and dietary pesticide exposure on neuroendocrine and olfactory responses in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Pollution, v. 318, p. 120938. https://doi.org/10.1016/j.envpol.2022.120938
Chen, Q., Gao, Z., Wang, K., Magnuson, J.T., Chen, Y., Li, M., Shi, H., and Xu, L., 2023, High accumulation of microplastic fibers in fish hindgut induces an enhancement of triphenyl phosphate hydroxylation: Environmental Pollution, v. 317, p. 120804. https://doi.org/10.1016/j.envpol.2022.120804
Magnuson, J.T., Leads, R.R., McGruer, V., Qian, L., Tanabe, P., Roberts, A.P., and Schlenk, D., 2023, Transcriptomic profiling of miR-203a inhibitor and miR-34b-injected zebrafish (Danio rerio) validates oil-induced neurological, cardiovascular and eye toxicity response pathways: Aquatic Toxicology, v. 254, p. 106356. https://doi.org/10.1016/j.aquatox.2022.106356
Liu, X., Liu, S., Qiu, W., Magnuson, J.T., Liu, Z., Yang, G., Chen, H., Li, Y., Xu, X., and Zheng, C., 2022, Cardiotoxicity of PFOA, PFOS, and PFOSA in early life stage zebrafish: Molecular changes to behavioral-level response: Sustainable Horizons, v. 3, p. 100027. https://doi.org/10.1016/j.horiz.2022.100027
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., McGruer, V., Schlenk, D., and Lydy, M.J., 2022, Dietary exposure to environmentally relevant pesticide mixtures impairs swimming performance and lipid homeostatic gene expression in Juvenile Chinook salmon at elevated water temperatures: Environmental Pollution, v. 314, p. 120308. https://doi.org/10.1016/j.envpol.2022.120308
Magnuson, J.T., Longenecker-Wright, Z., Havranek, I., Monticelli, G., Brekken, H.K., Kallenborn, R., Schlenk, D., Sydnes, M.O., and Pampanin, D.M., 2022, Bioaccumulation potential of the tricyclic antidepressant amitriptyline in a marine Polychaete, Nereis virens: Science of The Total Environment, v. 851, p. 158193. https://doi.org/10.1016/j.scitotenv.2022.158193
Xuan, R., Qiu, W., Zhou, Y., Magnuson, J.T., Luo, S., Greer, J.B., Xu, B., Liu, J., Xu, E.G., Schlenk, D., and Zheng, C., 2022, Parental transfer of an antibiotic mixture induces cardiotoxicity in early life-stage zebrafish: A cross-generational study: Science of The Total Environment, v. 849, p. 157726. https://doi.org/10.1016/j.scitotenv.2022.157726
Magnuson, J.T., Caceres, L., Sy, N., Ji, C., Tanabe, P., Gan, J., Lydy, M.J., and Schlenk, D., 2022, The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss): Environmental Science & Technology, v. 56, no. 16, p. 11482-11492. https://doi.org/10.1021/acs.est.2c01542
Chen, H., Qiu, W., Yang, X., Chen, F., Chen, J., Tang, L., Zhong, H., Magnuson, J.T., Zheng, C., and Xu, E.G., 2022, Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8438-8448. https://doi.org/10.1021/acs.est.1c08875
Qiu, W., Liu, T., Liu, X., Chen, H., Luo, S., Chen, Q., Magnuson, J.T., Zheng, C., Xu, E.G., and Schlenk, D., 2022, Enrofloxacin Induces Intestinal Microbiota-Mediated Immunosuppression in Zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8428-8437. https://doi.org/10.1021/acs.est.1c08712
Leads, R.R., Magnuson, J.T., Lucero, J., Lund, A.K., Schlenk, D., Chavez, J.R., and Roberts, A.P., 2022, Transcriptomic responses and apoptosis in larval red drum (Sciaenops ocellatus) co-exposed to crude oil and ultraviolet (UV) radiation: Marine Pollution Bulletin, v. 179, p. 113684. https://doi.org/10.1016/j.marpolbul.2022.113684
Magnuson, J.T., Fuller, N., Huff Hartz, K.E., Anzalone, S., Whitledge, G.W., Acuña, S., Lydy, M.J., and Schlenk, D., 2022, Dietary exposure to bifenthrin and fipronil impacts swimming performance in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Science & Technology, v. 56, no. 8, p. 5071-5080. https://doi.org/10.1021/acs.est.1c06609
Xu, B., Qiu, W., Du, J., Wan, Z., Zhou, J.L., Chen, H., Liu, R., Magnuson, J.T., and Zheng, C., 2022, Translocation, bioaccumulation, and distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in plants: iScience, v. 25, no. 4, p. 104061. https://doi.org/10.1016/j.isci.2022.104061
Fuller, N., Anzalone, S.E., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., Magnuson, J.T., Schlenk, D., and Lydy, M.J., 2022, Bioavailability of legacy and current-use pesticides in juvenile Chinook salmon habitat of the Sacramento River watershed: Importance of sediment characteristics and extraction techniques: Chemosphere, v. 298, p. 134174. https://doi.org/10.1016/j.chemosphere.2022.134174
Anzalone, S.E., Fuller, N.W., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Magnuson, J.T., Schlenk, D., Acuña, S., and Lydy, M.J., 2022, Pesticide residues in juvenile Chinook salmon and prey items of the Sacramento River watershed, California – A comparison of riverine and floodplain habitats: Environmental Pollution, v. 303, p. 119102.
https://doi.org/10.1016/j.envpol.2022.119102
Qiu, W., Chen, B., Tang, L., Zheng, C., Xu, B., Liu, Z., Magnuson, J.T., Zhang, S., Schlenk, D., Xu, E.G., and Xing, B., 2022, Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB: Environmental Science & Technology, v. 56, no. 7, p. 4251-4261. https://doi.org/10.1021/acs.est.1c07343
Magnuson, J.T., Qian, L., McGruer, V., Cheng, V., Volz, D.C., and Schlenk, D., 2022, Relationship between miR-203a inhibition and oil-induced toxicity in early life stage zebrafish (Danio rerio): Toxicology Reports, v. 9, p. 373-381. https://doi.org/10.1016/j.toxrep.2022.03.006
Qiu, W., Chen, H., Zhang, S., Xiong, Y., Zheng, M., Zhu, T., Park, M., Magnuson, J.T., Zheng, C., and El-Din, M.G., 2022, Remediation of surface water contaminated by pathogenic microorganisms using calcium peroxide: Matrix effect, micro-mechanisms and morphological-physiological changes: Water Research, v. 211, p. 118074. https://doi.org/10.1016/j.watres.2022.118074
McGruer, V., Khursigara, A.J., Magnuson, J.T., Esbaugh, A.J., Greer, J.B., and Schlenk, D., 2021, Exposure to Deepwater Horizon crude oil increases free cholesterol in larval red drum (Sciaenops ocellatus): Aquatic Toxicology, v. 241, p. 105988. https://doi.org/10.1016/j.aquatox.2021.105988
Fuller, N., Huff Hartz, K.E., Johanif, N., Magnuson, J.T., Robinson, E.K., Fulton, C.A., Poynton, H.C., Connon, R.E., and Lydy, M.J., 2021, Enhanced trophic transfer of chlorpyrifos from resistant Hyalella azteca to inland silversides (Menidia beryllina) and effects on acetylcholinesterase activity and swimming performance at varying temperatures: Environmental Pollution, v. 291, p. 118217. https://doi.org/10.1016/j.envpol.2021.118217
Greer, J.B., Magnuson, J.T., McGruer, V., Qian, L., Dasgupta, S., Volz, D.C., and Schlenk, D., 2021, miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish (Danio rerio) Embryos: Chemical Research in Toxicology, v. 34, no. 10, p. 2209-2215. https://doi.org/10.1021/acs.chemrestox.1c00238
Ajitha, V., Sarasan, M., Parvathi Sreevidya, C., Aswathy, C., Kachiprath, B., Mohandas, A., Singh, I.S.B., Hameed, A.S.S., Schlenk, D., Magnuson, J.T., and Puthumana, J., 2021, Cytotoxic impacts of treated electroplating industrial effluent and the comparative effect of their metal components (Zn, Hg, and Zn+Hg) on Danio rerio gill (DrG) cell line: Science of The Total Environment, v. 793, p. 148533. https://doi.org/10.1016/j.scitotenv.2021.148533
Ji, C., Tanabe, P., Shi, Q., Qian, L., McGruer, V., Magnuson, J.T., Wang, X., Gan, J., Gadepalli, R.S., Rimoldi, J., and Schlenk, D., 2021, Stage Dependent Enantioselective Metabolism of Bifenthrin in Embryos of Zebrafish (Danio rerio) and Japanese Medaka (Oryzias latipes): Environmental Science & Technology, v. 55, no. 13, p. 9087-9096. https://doi.org/10.1021/acs.est.1c01663
Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Lydy, M.J., and Schlenk, D., 2021, Transcriptomic and Histopathological Effects of Bifenthrin to the Brain of Juvenile Rainbow Trout (Oncorhynchus mykiss): Toxics, v. 9, no. 3, p. 48. https://doi.org/10.3390/toxics9030048
Harraka, G.T., Magnuson, J.T., Du, B., Wong, C.S., Maruya, K., and Schlenk, D., 2021, Evaluating the estrogenicity of an effluent-dominated river in California, USA: Comparisons of in vitro and in vivo bioassays: Science of The Total Environment, v. 758, p. 143965. https://doi.org/10.1016/j.scitotenv.2020.143965
Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., and Wang, C., 2021, Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems: Journal of Hazardous Materials, v. 404, p. 124083. https://doi.org/10.1016/j.jhazmat.2020.124083
Ji, C., Magnuson, J.T., Zhang, W., and Zhao, M., 2021, New insight into the enantioselective cytotoxicity of cypermethrin: imbalance between cell cycle and apoptosis: Journal of Hazardous Materials, v. 403, p. 123893. https://doi.org/10.1016/j.jhazmat.2020.123893
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Acuña, S., Schlenk, D., and Lydy, M.J., 2021, Effects of dietary cypermethrin exposure on swimming performance and expression of lipid homeostatic genes in livers of juvenile Chinook salmon, Oncorhynchus tshawytscha: Ecotoxicology, v. 30, no. 2, p. 257-267. https://doi.org/10.1007/s10646-021-02352-2
Chen, Q., Santos, M.M.d., Tanabe, P., Harraka, G.T., Magnuson, J.T., McGruer, V., Qiu, W., Shi, H., Snyder, S.A., and Schlenk, D., 2021, Bioassay guided analysis coupled with non-target chemical screening in polyethylene plastic shopping bag fragments after exposure to simulated gastric juice of Fish: Journal of Hazardous Materials, v. 401, p. 123421. https://doi.org/10.1016/j.jhazmat.2020.123421
Magnuson, J.T., Cryder, Z., Andrzejczyk, N.E., Harraka, G., Wolf, D.C., Gan, J., and Schlenk, D., 2020, Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment: Environmental Science & Technology, v. 54, no. 19, p. 12245-12253. https://doi.org/10.1021/acs.est.0c04847
Magnuson, J.T., Stieglitz, J.D., Garza, S.A., Benetti, D.D., Grosell, M., and Roberts, A.P., 2020, Development of visual function in early life stage mahi-mahi (coryphaena hippurus): Marine and Freshwater Behaviour and Physiology, v. 53, no. 5-6, p. 203-214. https://doi.org/10.1080/10236244.2020.1804300
Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., and Schlenk, D., 2020, Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring: Journal of Hazardous Materials, v. 399, p. 123009. https://doi.org/10.1016/j.jhazmat.2020.123009
Magnuson, J.T., Giroux, M., Cryder, Z., Gan, J., and Schlenk, D., 2020, The use of non-targeted metabolomics to assess the toxicity of bifenthrin to juvenile Chinook salmon (Oncorhynchus tshawytscha): Aquatic Toxicology, v. 224, p. 105518. https://doi.org/10.1016/j.aquatox.2020.105518
Bridges, K.N., Magnuson, J.T., Curran, T.E., Barker, A., Roberts, A.P., and Venables, B.J., 2019, Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure: Environmental Toxicology and Pharmacology, v. 69, p. 137-142. https://doi.org/10.1016/j.etap.2019.04.011
Perrichon, P., Stieglitz, J.D., Xu, E.G., Magnuson, J.T., Pasparakis, C., Mager, E.M., Wang, Y., Schlenk, D., Benetti, D.D., Roberts, A.P., Grosell, M., and Burggren, W.W., 2019, Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes: Developmental Dynamics, v. 248, no. 5, p. 337-350. https://doi.org/10.1002/dvdy.27
Xu, E.G., Magnuson, J.T., Diamante, G., Mager, E., Pasparakis, C., Grosell, M., Roberts, A.P., and Schlenk, D., 2018, Changes in microRNA–mRNA Signatures Agree with Morphological, Physiological, and Behavioral Changes in Larval Mahi-Mahi Treated with Deepwater Horizon Oil: Environmental Science & Technology, v. 52, no. 22, p. 13501-13510. https://doi.org/10.1021/acs.est.8b04169
Magnuson, J.T., Khursigara, A.J., Allmon, E.B., Esbaugh, A.J., and Roberts, A.P., 2018, Effects of Deepwater Horizon crude oil on ocular development in two estuarine fish species, red drum (Sciaenops ocellatus) and sheepshead minnow (Cyprinodon variegatus): Ecotoxicology and Environmental Safety, v. 166, p. 186-191. https://doi.org/10.1016/j.ecoenv.2018.09.087
Nielsen, K.M., Zhang, Y., Curran, T.E., Magnuson, J.T., Venables, B.J., Durrer, K.E., Allen, M.S., and Roberts, A.P., 2018, Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury: Environmental Science & Technology, v. 52, no. 15, p. 8774-8784. https://doi.org/10.1021/acs.est.8b01150
Nielsen, K.M., Krasnec, M.O., Magnuson, J.T., Morris, J.M., Gielazyn, M.L., Chavez, J.R., and Roberts, A.P., 2018, Influence of variable ultraviolet radiation and oil exposure duration on survival of red drum (Sciaenops ocellatus) larvae: Environmental Toxicology and Chemistry, v. 37, no. 9, p. 2372-2379. https://doi.org/10.1002/etc.4183
Xu, E.G., Khursigara, A.J., Magnuson, J., Hazard, E.S., Hardiman, G., Esbaugh, A.J., Roberts, A.P., and Schlenk, D., 2017, Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure to Weathered Deepwater Horizon Crude Oil: Developmental and Transcriptomic Consequences: Environmental Science & Technology, v. 51, no. 17, p. 10162-10172. https://doi.org/10.1021/acs.est.7b02037
Sweet, L.E., Magnuson, J., Garner, T.R., Alloy, M.M., Stieglitz, J.D., Benetti, D., Grosell, M., and Roberts, A.P., 2017, Exposure to ultraviolet radiation late in development increases the toxicity of oil to mahi-mahi (Coryphaena hippurus) embryos: Environmental Toxicology and Chemistry, v. 36, no. 6, p. 1592-1598. https://doi.org/10.1002/etc.3687
Magnuson, J.T., and Schlenk, D., 2023, Chapter 3.2.1 - Metabolism vs. metabolomics: Mechanisms of endocrine disruption, in Carnevali, O., and Hardiman, G., eds., Environmental Contaminants and Endocrine Health: Academic Press, p. 235-245.
https://doi.org/10.1016/B978-0-12-824464-7.00014-3

**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.

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Perfluorohexanesulfonic Acid (PFHxS) Dysregulates Lipid Homeostasis in Early Life Stage Fish

A frequently detected perfluorinated compound in the environment, perfluorohexanesulfonic acid (PFHxS), can alter lipid metabolism in developing fish. This work identifies a novel mechanism in which PFHxS targets lipid metabolism pathways by using multiple omic techniques and modeling approaches.
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Columbia Environmental Research Center
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Perfluorohexanesulfonic Acid (PFHxS) Dysregulates Lipid Homeostasis in Early Life Stage Fish

A frequently detected perfluorinated compound in the environment, perfluorohexanesulfonic acid (PFHxS), can alter lipid metabolism in developing fish. This work identifies a novel mechanism in which PFHxS targets lipid metabolism pathways by using multiple omic techniques and modeling approaches.
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Gut-Liver Axis: Review on How Microplastics Can Cause Toxicity Through an Interaction Between the Gut, Microbial Community, and Liver

Microplastics can cause liver damage when consumed by terrestrial and aquatic organisms. This review proposes a novel mechanism to help explain the toxic effects following ingestion, which involves the gut, microbial community, and liver through the gut-liver axis.
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Columbia Environmental Research Center
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Gut-Liver Axis: Review on How Microplastics Can Cause Toxicity Through an Interaction Between the Gut, Microbial Community, and Liver

Microplastics can cause liver damage when consumed by terrestrial and aquatic organisms. This review proposes a novel mechanism to help explain the toxic effects following ingestion, which involves the gut, microbial community, and liver through the gut-liver axis.
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Zebrafish (Danio rerio)

Study Finds PFOSA Can Suppress Immune Function in Developing Zebrafish (Danio rerio)

The Stockholm Convention has labeled PFOS a “persistent organic pollutant” due to its long-enduring prevalence, negative toxicological effects, and ability to bioaccumulate in living things. Concerns about PFOSA have been raised due to its similarity to PFOS, its ability to metabolize into PFOS, and its persistent use today
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Columbia Environmental Research Center
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Study Finds PFOSA Can Suppress Immune Function in Developing Zebrafish (Danio rerio)

The Stockholm Convention has labeled PFOS a “persistent organic pollutant” due to its long-enduring prevalence, negative toxicological effects, and ability to bioaccumulate in living things. Concerns about PFOSA have been raised due to its similarity to PFOS, its ability to metabolize into PFOS, and its persistent use today
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Comprehensive Research on PFAS Exposomics and Risk Assessment

The Columbia Environmental Research Center (CERC) conducts cutting-edge research on per- and polyfluoroalkyl substances (PFAS) through the lens of the One Health Paradigm, emphasizing the interconnectedness of human, animal, and environmental health.
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Columbia Environmental Research Center
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Comprehensive Research on PFAS Exposomics and Risk Assessment

The Columbia Environmental Research Center (CERC) conducts cutting-edge research on per- and polyfluoroalkyl substances (PFAS) through the lens of the One Health Paradigm, emphasizing the interconnectedness of human, animal, and environmental health.
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Fishing, Hunting and Subsistence Living Integrated Science Team

The Fishing, Hunting, and Subsistence Living Integrated Science Team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively...
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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Toxic Substances Hydrology
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Fishing, Hunting and Subsistence Living Integrated Science Team

The Fishing, Hunting, and Subsistence Living Integrated Science Team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively...
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Abundance of microplastics in a typical urban wetland in China: Association with occurrence and carbon storage

Microplastics (MPs) are gaining attention for their widespread presence and toxicity in ecosystems. However, their role as a carbon source in urban wetland carbon sinks is still unclear. In this study, the microplastic-carbon (MP-C) was firstly quantified based on the abundance and occurrence characteristics, including MP morphology, size and type in the Sanyang Wetland, a typical urban...
Authors
Haowen Zhang, Mengjie Pu, Ming Zheng, Bentuo Xu, Jason Tyler Magnuson, Qiqing Chen, Xiangrong Xu, Xiangyong Zheng, Min Zhao, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Exposure to the Polychlorinated biphenyl mixture Aroclor 1254 elicits neurological and cardiac developmental effects in early life stage zebrafish (Danio rerio)

The goal of this study was to compare the bioaccumulation of the PCB mixture Aroclor 1254 in zebrafish to cardiac and neurologic outcomes. The establishment of effect concentrations (ECs) for cardiac and neurotoxic effects of PCBs in early life stage fish is challenging due to a lack of measured PCB concentrations in test media (e.g., fish tissue), the lack of standard exposure methods...
Authors
Corey A. Green, Jeffrey M. Morris, Jason Tyler Magnuson, Rachel Leads, Claire R. Lay, Michel Gielazyn, Lisa Rosman, Daniel Schlenk, Aaron P. Roberts
By
Ecosystems Mission Area, Columbia Environmental Research Center

A universal method for the simultaneous determination of environmental pollutants in marine biological samples: Per- and polyfluoroalkyl substances and antibiotics as a case study

Conventional detection technologies for environmental contaminants have primarily focused on providing accurate qualitative and quantitative evaluations for single pollutant types, leading to increased costs and an inability to satisfy the growing demand for detecting a broader spectrum of pollutants. Here, we introduced a novel analytical method to simultaneously measure the...
Authors
Di Fang, Ge Yang, Bentuo Xu, Jialin Li, Jiayi Lin, Chunmiao Zheng, Jason Tyler Magnuson, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Perfluorohexanesulfonic acid (PFHxS) induces hepatotoxicity through the PPAR signaling pathway in larval zebrafish (Danio rerio)

In recent years, the industrial substitution of long-chain per- and polyfluoroalkyl substances (PFAS) with short-chain alternatives has become increasingly prevalent, resulting in the widespread environmental detection of perfluorohexanesulfonic acid (PFHxS), a short-chain PFAS. However, there remains limited information about the potential adverse effects of PFHxS at environmental...
Authors
Haolin Liao, Ying-Jie He, Shuwen Zhang, Xinyuan Kang, Xin Yang, Bentuo Xu, Jason Tyler Magnuson, Shuping Wang, Chunmiao Zheng, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Establishment of a cell culture from Daphnia magna as an in vitro model for (eco)toxicology assays: Case study using Bisphenol A as a representative cytotoxic and endocrine disrupting chemical

Bisphenol A (BPA) is a widely used industrial compound found in polycarbonate plastics, epoxy resin, and various polymer materials, leading to its ubiquitous presence in the environment. The toxicity of BPA to aquatic organisms has been well documented following in vivo exposure scenarios, with known cytotoxic and endocrine-disrupting effects. As such, BPA was used in this study as a...
Authors
Sreevidya CP, Manoj Kumar TM, Soumya Balakrishnana, Suresh Kunjiramana, Manomi Sarasan, Jason Tyler Magnuson, Jayesh Puthumana
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Ecosystems Mission Area, Columbia Environmental Research Center

Immunotoxic response of bio-based plastic on early life stage zebrafish (Danio rerio): A safe alternative to petroleum-based plastics?

Bio-based plastics are marketed as environmentally friendly alternatives to petroleum-based plastics, although they require specific composting conditions for degradation, which leads to their accumulation in the environment and potential risks to aquatic organisms. We hypothesized that the accumulation of bio-based plastics may induce immunotoxic responses in fish. Our research focused...
Authors
Haodong Cheng, Yao Zou, Bin Lu, Jiazhen Wang, Rongrong Xuan, Jason Tyler Magnuson, Chunmiao Zheng, Wenhui Qiu
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Ecosystems Mission Area, Columbia Environmental Research Center

Perfluorohexanesulfonic acid (PFHxS) impairs lipid homeostasis in zebrafish larvae through activation of PPARα

Perfluorohexanesulfonic acid (PFHxS), an emerging short-chain per- and polyfluoroalkyl substance, has been frequently detected in aquatic environments. Adverse outcome pathway studies have shown that perfluorinated compounds impair lipid homeostasis through peroxisome proliferator activated receptors (PPARs). However, many of these studies were performed at high concentrations and may...
Authors
Ying-Jie He, Haolin Liao, Ge Yang, Wenhui Qui, Rongrong Xuan, Guomao Zheng, Bentuo Xu, Xin Yang, Jason Tyler Magnuson, Daniel Schlenk, Chunmiao Zheng
By
Ecosystems Mission Area, Columbia Environmental Research Center

Dopaminergic and anti-estrogenic responses in juvenile steelhead (Oncorhynchus mykiss) exposed to bifenthrin

The frequency of detection and concentrations of bifenthrin, a pyrethroid insecticide, in the waterways inhabited by the endangered species, steelhead trout (Oncorhynchus mykiss), has become a significant concern for regulatory agencies. Endocrine disruption has been observed with estrogenic and anti-estrogenic responses in fish species at different life stages. Since several studies...
Authors
Jason Tyler Magnuson, Nathan D. Sy, Philip Tanabe, Chenyang Ji, Jay Gan, Daniel Schlenk
By
Ecosystems Mission Area, Columbia Environmental Research Center

Perfluorooctane sulfonamide induced autotoxic effects on the zebrafish immune system

Perfluorooctane sulfonamide (PFOSA) is an immediate perfluorooctanesulfonate (PFOS) precursor (PreFOS). Previous studies have shown PFOSA to induce stronger toxic responses compared to other perfluorinated compounds (PFCs). However, the specific nature of PFOSA-induced toxicity, whether autonomous or mediated by its metabolite PFOS, has not been fully elucidated. This study...
Authors
Honghong Chen, Yao Zou, Xingyuan Kang, Ge Yang, Xinghe Yang, Yingying Yao, Jason Tyler Magnuson, Xinde Cao, Wenhui Qiu, Elvis Zu Genbo, Chunmiao Zheng
By
Ecosystems Mission Area, Columbia Environmental Research Center

The roles of diet and habitat use in pesticide bioaccumulation by juvenile Chinook Salmon: Insights from stable isotopes and fatty acid biomarkers

Stable isotopes (SI) and fatty acid (FA) biomarkers can provide insights regarding trophic pathways and habitats associated with contaminant bioaccumulation. We assessed relationships between SI and FA biomarkers and published data on concentrations of two pesticides [dichlorodiphenyltrichloroethane and degradation products (DDX) and bifenthrin] in juvenile Chinook Salmon (Oncorhynchus...
Authors
Sara E. Anzalone, Neil W. Fuller, Kara E. Huff Hartz, Gregory W. Whitledge, Jason Tyler Magnuson, Daniel Schlenk, Shawn Acuña, Matt R. Whiles, Michael J. Lydy
By
Ecosystems Mission Area, Columbia Environmental Research Center

Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis

Microplastics (MPs) are environmental contaminants that are present in all environments and can enter the human body, accumulate in various organs, and cause harm through the ingestion of food, inhalation, and dermal contact. The connection between bowel and liver disease and the interplay between gut, liver, and flora has been conceptualized as the “gut-liver axis”. Microplastics can...
Authors
Xiaomei Wang, Kaili Deng, Pei Zhen Zhang, Qiqing Chen, Jason Tyler Magnuson, Wenhui Qiu, Yuping Zhou
By
Ecosystems Mission Area, Columbia Environmental Research Center

Mixture effects of per- and polyfluoroalkyl substances on embryonic and larval Sheepshead Minnows (Cyprinodon variegatus)

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and persistent environmental contaminants originating from many everyday products. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are two PFAS that are commonly found at high concentrations in aquatic environments. Both chemicals have previously been shown to be toxic to fish, as well as having complex and...
Authors
Philip Tanabe, Peter B. Key, Katy W. Chung, Emily C. Pisarski, Jessica L. Reiner, Rodowa. Alix E., Jason Tyler Magnuson, Marie E. DeLorenzo
By
Ecosystems Mission Area, Columbia Environmental Research Center

Non-USGS Publications**

Tang, L., Qiu, W., Zhang, S., Wang, J., Yang, X., Xu, B., Magnuson, J.T., Xu, E.G., Wu, M., and Zheng, C., 2023, Poly- and perfluoroalkyl substances induce immunotoxicity via the TLR pathway in zebrafish: Links to carbon-chain length: Environmental Science & Technology, v. 57, no. 15, p. 6139-6149. https://doi.org/10.1021/acs.est.2c09716
Magnuson, J.T., and Sandheinrich, M.B., 2023, Relation among mercury, selenium, and
biomarkers of oxidative stress in northern pike (Esox lucius): Toxics, v. 11, no. 3, p. 244.
https://www.mdpi.com/2305-6304/11/3/244
Pampanin, D.M., Arnli, W.B., Magnuson, J.T., Monticelli, G., Dam, M., Mikalsen, S.-O., and Sydnes, M.O., 2023, Study of the long-finned pilot whale (Globicephala melas) bile content - An indicator of ocean health: Marine Pollution Bulletin, v. 189, p. 114795. https://doi.org/10.1016/j.marpolbul.2023.114795
Zhang, S., Zheng, M., Yang, G., Zhang, T., Magnuson, J.T., Chen, H., Zheng, C., and Qiu, W., 2023, Sunlight-mediated CaO2 inactivation of pathogen indicator organisms in surface water system: Roles of reactive species, characterization of pathogen inactivation: Water Research, v. 233, p. 119756. https://doi.org/10.1016/j.watres.2023.119756
Liu, S., Qiu, W., Li, R., Chen, B., Wu, X., Magnuson, J.T., Xu, B., Luo, S., Xu, E.G., and Zheng, C., 2023, Perfluorononanoic acid induces neurotoxicity via synaptogenesis signaling in zebrafish, v. 57, no. 9, p. 3783-3793. https://doi.org/10.1021/acs.est.2c06739
Magnuson, J.T., Fuller, N., McGruer, V., Huff Hartz, K.E., Acuña, S., Whitledge, G.W., Lydy, M.J., and Schlenk, D., 2023, Effect of temperature and dietary pesticide exposure on neuroendocrine and olfactory responses in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Pollution, v. 318, p. 120938. https://doi.org/10.1016/j.envpol.2022.120938
Chen, Q., Gao, Z., Wang, K., Magnuson, J.T., Chen, Y., Li, M., Shi, H., and Xu, L., 2023, High accumulation of microplastic fibers in fish hindgut induces an enhancement of triphenyl phosphate hydroxylation: Environmental Pollution, v. 317, p. 120804. https://doi.org/10.1016/j.envpol.2022.120804
Magnuson, J.T., Leads, R.R., McGruer, V., Qian, L., Tanabe, P., Roberts, A.P., and Schlenk, D., 2023, Transcriptomic profiling of miR-203a inhibitor and miR-34b-injected zebrafish (Danio rerio) validates oil-induced neurological, cardiovascular and eye toxicity response pathways: Aquatic Toxicology, v. 254, p. 106356. https://doi.org/10.1016/j.aquatox.2022.106356
Liu, X., Liu, S., Qiu, W., Magnuson, J.T., Liu, Z., Yang, G., Chen, H., Li, Y., Xu, X., and Zheng, C., 2022, Cardiotoxicity of PFOA, PFOS, and PFOSA in early life stage zebrafish: Molecular changes to behavioral-level response: Sustainable Horizons, v. 3, p. 100027. https://doi.org/10.1016/j.horiz.2022.100027
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., McGruer, V., Schlenk, D., and Lydy, M.J., 2022, Dietary exposure to environmentally relevant pesticide mixtures impairs swimming performance and lipid homeostatic gene expression in Juvenile Chinook salmon at elevated water temperatures: Environmental Pollution, v. 314, p. 120308. https://doi.org/10.1016/j.envpol.2022.120308
Magnuson, J.T., Longenecker-Wright, Z., Havranek, I., Monticelli, G., Brekken, H.K., Kallenborn, R., Schlenk, D., Sydnes, M.O., and Pampanin, D.M., 2022, Bioaccumulation potential of the tricyclic antidepressant amitriptyline in a marine Polychaete, Nereis virens: Science of The Total Environment, v. 851, p. 158193. https://doi.org/10.1016/j.scitotenv.2022.158193
Xuan, R., Qiu, W., Zhou, Y., Magnuson, J.T., Luo, S., Greer, J.B., Xu, B., Liu, J., Xu, E.G., Schlenk, D., and Zheng, C., 2022, Parental transfer of an antibiotic mixture induces cardiotoxicity in early life-stage zebrafish: A cross-generational study: Science of The Total Environment, v. 849, p. 157726. https://doi.org/10.1016/j.scitotenv.2022.157726
Magnuson, J.T., Caceres, L., Sy, N., Ji, C., Tanabe, P., Gan, J., Lydy, M.J., and Schlenk, D., 2022, The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss): Environmental Science & Technology, v. 56, no. 16, p. 11482-11492. https://doi.org/10.1021/acs.est.2c01542
Chen, H., Qiu, W., Yang, X., Chen, F., Chen, J., Tang, L., Zhong, H., Magnuson, J.T., Zheng, C., and Xu, E.G., 2022, Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8438-8448. https://doi.org/10.1021/acs.est.1c08875
Qiu, W., Liu, T., Liu, X., Chen, H., Luo, S., Chen, Q., Magnuson, J.T., Zheng, C., Xu, E.G., and Schlenk, D., 2022, Enrofloxacin Induces Intestinal Microbiota-Mediated Immunosuppression in Zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8428-8437. https://doi.org/10.1021/acs.est.1c08712
Leads, R.R., Magnuson, J.T., Lucero, J., Lund, A.K., Schlenk, D., Chavez, J.R., and Roberts, A.P., 2022, Transcriptomic responses and apoptosis in larval red drum (Sciaenops ocellatus) co-exposed to crude oil and ultraviolet (UV) radiation: Marine Pollution Bulletin, v. 179, p. 113684. https://doi.org/10.1016/j.marpolbul.2022.113684
Magnuson, J.T., Fuller, N., Huff Hartz, K.E., Anzalone, S., Whitledge, G.W., Acuña, S., Lydy, M.J., and Schlenk, D., 2022, Dietary exposure to bifenthrin and fipronil impacts swimming performance in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Science & Technology, v. 56, no. 8, p. 5071-5080. https://doi.org/10.1021/acs.est.1c06609
Xu, B., Qiu, W., Du, J., Wan, Z., Zhou, J.L., Chen, H., Liu, R., Magnuson, J.T., and Zheng, C., 2022, Translocation, bioaccumulation, and distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in plants: iScience, v. 25, no. 4, p. 104061. https://doi.org/10.1016/j.isci.2022.104061
Fuller, N., Anzalone, S.E., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., Magnuson, J.T., Schlenk, D., and Lydy, M.J., 2022, Bioavailability of legacy and current-use pesticides in juvenile Chinook salmon habitat of the Sacramento River watershed: Importance of sediment characteristics and extraction techniques: Chemosphere, v. 298, p. 134174. https://doi.org/10.1016/j.chemosphere.2022.134174
Anzalone, S.E., Fuller, N.W., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Magnuson, J.T., Schlenk, D., Acuña, S., and Lydy, M.J., 2022, Pesticide residues in juvenile Chinook salmon and prey items of the Sacramento River watershed, California – A comparison of riverine and floodplain habitats: Environmental Pollution, v. 303, p. 119102.
https://doi.org/10.1016/j.envpol.2022.119102
Qiu, W., Chen, B., Tang, L., Zheng, C., Xu, B., Liu, Z., Magnuson, J.T., Zhang, S., Schlenk, D., Xu, E.G., and Xing, B., 2022, Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB: Environmental Science & Technology, v. 56, no. 7, p. 4251-4261. https://doi.org/10.1021/acs.est.1c07343
Magnuson, J.T., Qian, L., McGruer, V., Cheng, V., Volz, D.C., and Schlenk, D., 2022, Relationship between miR-203a inhibition and oil-induced toxicity in early life stage zebrafish (Danio rerio): Toxicology Reports, v. 9, p. 373-381. https://doi.org/10.1016/j.toxrep.2022.03.006
Qiu, W., Chen, H., Zhang, S., Xiong, Y., Zheng, M., Zhu, T., Park, M., Magnuson, J.T., Zheng, C., and El-Din, M.G., 2022, Remediation of surface water contaminated by pathogenic microorganisms using calcium peroxide: Matrix effect, micro-mechanisms and morphological-physiological changes: Water Research, v. 211, p. 118074. https://doi.org/10.1016/j.watres.2022.118074
McGruer, V., Khursigara, A.J., Magnuson, J.T., Esbaugh, A.J., Greer, J.B., and Schlenk, D., 2021, Exposure to Deepwater Horizon crude oil increases free cholesterol in larval red drum (Sciaenops ocellatus): Aquatic Toxicology, v. 241, p. 105988. https://doi.org/10.1016/j.aquatox.2021.105988
Fuller, N., Huff Hartz, K.E., Johanif, N., Magnuson, J.T., Robinson, E.K., Fulton, C.A., Poynton, H.C., Connon, R.E., and Lydy, M.J., 2021, Enhanced trophic transfer of chlorpyrifos from resistant Hyalella azteca to inland silversides (Menidia beryllina) and effects on acetylcholinesterase activity and swimming performance at varying temperatures: Environmental Pollution, v. 291, p. 118217. https://doi.org/10.1016/j.envpol.2021.118217
Greer, J.B., Magnuson, J.T., McGruer, V., Qian, L., Dasgupta, S., Volz, D.C., and Schlenk, D., 2021, miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish (Danio rerio) Embryos: Chemical Research in Toxicology, v. 34, no. 10, p. 2209-2215. https://doi.org/10.1021/acs.chemrestox.1c00238
Ajitha, V., Sarasan, M., Parvathi Sreevidya, C., Aswathy, C., Kachiprath, B., Mohandas, A., Singh, I.S.B., Hameed, A.S.S., Schlenk, D., Magnuson, J.T., and Puthumana, J., 2021, Cytotoxic impacts of treated electroplating industrial effluent and the comparative effect of their metal components (Zn, Hg, and Zn+Hg) on Danio rerio gill (DrG) cell line: Science of The Total Environment, v. 793, p. 148533. https://doi.org/10.1016/j.scitotenv.2021.148533
Ji, C., Tanabe, P., Shi, Q., Qian, L., McGruer, V., Magnuson, J.T., Wang, X., Gan, J., Gadepalli, R.S., Rimoldi, J., and Schlenk, D., 2021, Stage Dependent Enantioselective Metabolism of Bifenthrin in Embryos of Zebrafish (Danio rerio) and Japanese Medaka (Oryzias latipes): Environmental Science & Technology, v. 55, no. 13, p. 9087-9096. https://doi.org/10.1021/acs.est.1c01663
Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Lydy, M.J., and Schlenk, D., 2021, Transcriptomic and Histopathological Effects of Bifenthrin to the Brain of Juvenile Rainbow Trout (Oncorhynchus mykiss): Toxics, v. 9, no. 3, p. 48. https://doi.org/10.3390/toxics9030048
Harraka, G.T., Magnuson, J.T., Du, B., Wong, C.S., Maruya, K., and Schlenk, D., 2021, Evaluating the estrogenicity of an effluent-dominated river in California, USA: Comparisons of in vitro and in vivo bioassays: Science of The Total Environment, v. 758, p. 143965. https://doi.org/10.1016/j.scitotenv.2020.143965
Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., and Wang, C., 2021, Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems: Journal of Hazardous Materials, v. 404, p. 124083. https://doi.org/10.1016/j.jhazmat.2020.124083
Ji, C., Magnuson, J.T., Zhang, W., and Zhao, M., 2021, New insight into the enantioselective cytotoxicity of cypermethrin: imbalance between cell cycle and apoptosis: Journal of Hazardous Materials, v. 403, p. 123893. https://doi.org/10.1016/j.jhazmat.2020.123893
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Acuña, S., Schlenk, D., and Lydy, M.J., 2021, Effects of dietary cypermethrin exposure on swimming performance and expression of lipid homeostatic genes in livers of juvenile Chinook salmon, Oncorhynchus tshawytscha: Ecotoxicology, v. 30, no. 2, p. 257-267. https://doi.org/10.1007/s10646-021-02352-2
Chen, Q., Santos, M.M.d., Tanabe, P., Harraka, G.T., Magnuson, J.T., McGruer, V., Qiu, W., Shi, H., Snyder, S.A., and Schlenk, D., 2021, Bioassay guided analysis coupled with non-target chemical screening in polyethylene plastic shopping bag fragments after exposure to simulated gastric juice of Fish: Journal of Hazardous Materials, v. 401, p. 123421. https://doi.org/10.1016/j.jhazmat.2020.123421
Magnuson, J.T., Cryder, Z., Andrzejczyk, N.E., Harraka, G., Wolf, D.C., Gan, J., and Schlenk, D., 2020, Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment: Environmental Science & Technology, v. 54, no. 19, p. 12245-12253. https://doi.org/10.1021/acs.est.0c04847
Magnuson, J.T., Stieglitz, J.D., Garza, S.A., Benetti, D.D., Grosell, M., and Roberts, A.P., 2020, Development of visual function in early life stage mahi-mahi (coryphaena hippurus): Marine and Freshwater Behaviour and Physiology, v. 53, no. 5-6, p. 203-214. https://doi.org/10.1080/10236244.2020.1804300
Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., and Schlenk, D., 2020, Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring: Journal of Hazardous Materials, v. 399, p. 123009. https://doi.org/10.1016/j.jhazmat.2020.123009
Magnuson, J.T., Giroux, M., Cryder, Z., Gan, J., and Schlenk, D., 2020, The use of non-targeted metabolomics to assess the toxicity of bifenthrin to juvenile Chinook salmon (Oncorhynchus tshawytscha): Aquatic Toxicology, v. 224, p. 105518. https://doi.org/10.1016/j.aquatox.2020.105518
Bridges, K.N., Magnuson, J.T., Curran, T.E., Barker, A., Roberts, A.P., and Venables, B.J., 2019, Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure: Environmental Toxicology and Pharmacology, v. 69, p. 137-142. https://doi.org/10.1016/j.etap.2019.04.011
Perrichon, P., Stieglitz, J.D., Xu, E.G., Magnuson, J.T., Pasparakis, C., Mager, E.M., Wang, Y., Schlenk, D., Benetti, D.D., Roberts, A.P., Grosell, M., and Burggren, W.W., 2019, Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes: Developmental Dynamics, v. 248, no. 5, p. 337-350. https://doi.org/10.1002/dvdy.27
Xu, E.G., Magnuson, J.T., Diamante, G., Mager, E., Pasparakis, C., Grosell, M., Roberts, A.P., and Schlenk, D., 2018, Changes in microRNA–mRNA Signatures Agree with Morphological, Physiological, and Behavioral Changes in Larval Mahi-Mahi Treated with Deepwater Horizon Oil: Environmental Science & Technology, v. 52, no. 22, p. 13501-13510. https://doi.org/10.1021/acs.est.8b04169
Magnuson, J.T., Khursigara, A.J., Allmon, E.B., Esbaugh, A.J., and Roberts, A.P., 2018, Effects of Deepwater Horizon crude oil on ocular development in two estuarine fish species, red drum (Sciaenops ocellatus) and sheepshead minnow (Cyprinodon variegatus): Ecotoxicology and Environmental Safety, v. 166, p. 186-191. https://doi.org/10.1016/j.ecoenv.2018.09.087
Nielsen, K.M., Zhang, Y., Curran, T.E., Magnuson, J.T., Venables, B.J., Durrer, K.E., Allen, M.S., and Roberts, A.P., 2018, Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury: Environmental Science & Technology, v. 52, no. 15, p. 8774-8784. https://doi.org/10.1021/acs.est.8b01150
Nielsen, K.M., Krasnec, M.O., Magnuson, J.T., Morris, J.M., Gielazyn, M.L., Chavez, J.R., and Roberts, A.P., 2018, Influence of variable ultraviolet radiation and oil exposure duration on survival of red drum (Sciaenops ocellatus) larvae: Environmental Toxicology and Chemistry, v. 37, no. 9, p. 2372-2379. https://doi.org/10.1002/etc.4183
Xu, E.G., Khursigara, A.J., Magnuson, J., Hazard, E.S., Hardiman, G., Esbaugh, A.J., Roberts, A.P., and Schlenk, D., 2017, Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure to Weathered Deepwater Horizon Crude Oil: Developmental and Transcriptomic Consequences: Environmental Science & Technology, v. 51, no. 17, p. 10162-10172. https://doi.org/10.1021/acs.est.7b02037
Sweet, L.E., Magnuson, J., Garner, T.R., Alloy, M.M., Stieglitz, J.D., Benetti, D., Grosell, M., and Roberts, A.P., 2017, Exposure to ultraviolet radiation late in development increases the toxicity of oil to mahi-mahi (Coryphaena hippurus) embryos: Environmental Toxicology and Chemistry, v. 36, no. 6, p. 1592-1598. https://doi.org/10.1002/etc.3687
Magnuson, J.T., and Schlenk, D., 2023, Chapter 3.2.1 - Metabolism vs. metabolomics: Mechanisms of endocrine disruption, in Carnevali, O., and Hardiman, G., eds., Environmental Contaminants and Endocrine Health: Academic Press, p. 235-245.
https://doi.org/10.1016/B978-0-12-824464-7.00014-3

**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.

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