The U.S. Geological Survey (USGS) National Water Use Program is responsible for compiling and disseminating the Nation's water-use data. Working in cooperation with local, State, and Federal agencies, the USGS has published an estimate of water use in the United States every 5 years, beginning in 1950. These 5-year compilations contain water-use estimates that are aggregated to the county level in the United States. This USGS data release contains summaries of method codes used in the 2015 national compilation of public supply, self-supplied domestic, thermoelectric, and irrigation water-use data. This data release also contains the county-level water-use estimates that support the evaluations in Luukkonen and others (2021). Finally, this data release contains summaries of regional medians and interquartile ranges from 1985 to 2015 that were used to highlight areas of unexpected variability, consistency and/or potential values that warrant further investigation. This data release supports the following publication: Luukkonen, C.L., Belitz, K., Sullivan, S.L., and Sargent, P., 2021, Factors affecting uncertainty of public supply, self-supplied domestic, irrigation, and thermoelectric water-use data, 1985-2015-Evaluation of information sources, estimation methods, and data variability: U.S. Geological Survey Scientific Investigations Report 2021-5082, 78 p., https://doi.org/10.3133/sir20215082.