What does "georeferenced" mean?
Georeferencing means that the internal coordinate system of a map or aerial photo image can be related to a ground system of geographic coordinates. The relevant coordinate transforms are typically stored within the image file (GeoPDF and GeoTIFF are examples), though there are many possible mechanisms for implementing georeferencing. The most visible effect of georeferencing is that display software can show ground coordinates (such as latitude/longitude or UTM coordinates) and also measure ground distances and areas. Doing these things with USGS GeoPDF maps requires the free TerraGo toolbar extension to Adobe Reader.