Donald Tillitt, PhD (Former Employee)
Science and Products
Filter Total Items: 215
TanA: a fluorogenic probe for thiaminase activity TanA: a fluorogenic probe for thiaminase activity
A fluorogenic thiamine analogue is presented as a fluorescent probe for thiaminase activity. The emission of the fluorophore is quenched by photoinduced electron transfer (PET) to the N-substituted pyridinium portion of the probe. Action of the enzyme releases the free pyridine group causing a substantial increase in fluorescence.
Authors
Wanjun Zhu, James L. Zajicek, Donald E. Tillitt, Timothy E. Glass
Environmental survey in the Tuul and Orkhon River basins of north-central Mongolia, 2010: Metals and other elements in streambed sediment and floodplain soil Environmental survey in the Tuul and Orkhon River basins of north-central Mongolia, 2010: Metals and other elements in streambed sediment and floodplain soil
Streambed sediment and subsurface floodplain soil were sampled for elemental analyses from 15 locations in river basins of north-central Mongolia during August 2010. Our primary objective was to conduct a reconnaissance-level assessment of potential inputs of toxicologically important metals and metalloids to Lake Baikal, Russia, that might originate from mining and urban activities...
Authors
William G. Brumbaugh, Donald E. Tillitt, Thomas W. May, Ch. Javzan, V. T. Komov
U.S. Geological Survey environmental health science strategy — Providing environmental health science for a changing world U.S. Geological Survey environmental health science strategy — Providing environmental health science for a changing world
Executive Summary America has an abundance of natural resources. We have bountiful clean water, fertile soil, and unrivaled national parks, wildlife refuges, and public lands. These resources enrich our lives and preserve our health and wellbeing. These resources have been maintained because of our history of respect for their value and an enduring commitment to their vigilant protection...
Authors
Patricia R. Bright, Herbert T. Buxton, Laurie S. Balistrieri, Larry B. Barber, Francis H. Chapelle, Paul C. Cross, David P. Krabbenhoft, Geoffrey S. Plumlee, Jonathan M. Sleeman, Donald E. Tillitt, Patricia L. Toccalino, James R. Winton
Thiamine deficiency: a viable hypothesis for paralytic syndrome in Baltic birds. Commentary on Sonne et al., 2012. A review of the factors causing paralysis in wild birds: implications for the paralytic syndrome observed in the Baltic Sea. Science of t Thiamine deficiency: a viable hypothesis for paralytic syndrome in Baltic birds. Commentary on Sonne et al., 2012. A review of the factors causing paralysis in wild birds: implications for the paralytic syndrome observed in the Baltic Sea. Science of t
In a recent assessment of hypotheses presented by Balk et al. (2009) regarding the etiology of a paralytic disease inflicting bird populations in Northern Europe, Sonne et al. (2012) “call for a major coordinated effort on research…” to “… integrate clinical, physiological, ecological and demographic investigations at all levels to better dissect the causes, the effects on ecosystems and...
Authors
Donald E. Tillitt, Clifford E. Kraft, Dale C. Honeyfield, John D. Fitzsimons
Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development
Thiamin pyrophosphokinase (TPK) converts thiamin to its active form, thiamin diphosphate. In humans, TPK expression is down-regulated in some thiamin deficiency related syndrome, and enhanced during pregnancy. Rainbow trout are also vulnerable to thiamin deficiency in wild life and are useful models for thiamin metabolism research. We identified the tpk gene transcript including seven...
Authors
Shinya Yuge, Catherine A. Richter, Maureen K. Wright-Osment, Diane Nicks, Stephanie K. Saloka, Donald E. Tillitt, Weiming Li
Paenibacillus thiaminolyticus is not the cause of thiamine deficiency impeding lake trout (Salvelinus namaycush) recruitment in the Great Lakes Paenibacillus thiaminolyticus is not the cause of thiamine deficiency impeding lake trout (Salvelinus namaycush) recruitment in the Great Lakes
Thiamine (vitamin B1) deficiency is a global concern affecting wildlife, livestock, and humans. In Great Lakes salmonines, thiamine deficiency causes embryo mortality and is an impediment to restoration of native lake trout (Salvelinus namaycush) stocks. Thiamine deficiency in fish may result from a diet of prey with high levels of thiaminase I. The discoveries that the bacterial species
Authors
Catherine A. Richter, Allison N. Evans, Maureen K. Wright-Osment, James L. Zajicek, Scott A. Heppell, Stephen C. Riley, Charles C. Krueger, Donald E. Tillitt
Science and Products
Filter Total Items: 215
TanA: a fluorogenic probe for thiaminase activity TanA: a fluorogenic probe for thiaminase activity
A fluorogenic thiamine analogue is presented as a fluorescent probe for thiaminase activity. The emission of the fluorophore is quenched by photoinduced electron transfer (PET) to the N-substituted pyridinium portion of the probe. Action of the enzyme releases the free pyridine group causing a substantial increase in fluorescence.
Authors
Wanjun Zhu, James L. Zajicek, Donald E. Tillitt, Timothy E. Glass
Environmental survey in the Tuul and Orkhon River basins of north-central Mongolia, 2010: Metals and other elements in streambed sediment and floodplain soil Environmental survey in the Tuul and Orkhon River basins of north-central Mongolia, 2010: Metals and other elements in streambed sediment and floodplain soil
Streambed sediment and subsurface floodplain soil were sampled for elemental analyses from 15 locations in river basins of north-central Mongolia during August 2010. Our primary objective was to conduct a reconnaissance-level assessment of potential inputs of toxicologically important metals and metalloids to Lake Baikal, Russia, that might originate from mining and urban activities...
Authors
William G. Brumbaugh, Donald E. Tillitt, Thomas W. May, Ch. Javzan, V. T. Komov
U.S. Geological Survey environmental health science strategy — Providing environmental health science for a changing world U.S. Geological Survey environmental health science strategy — Providing environmental health science for a changing world
Executive Summary America has an abundance of natural resources. We have bountiful clean water, fertile soil, and unrivaled national parks, wildlife refuges, and public lands. These resources enrich our lives and preserve our health and wellbeing. These resources have been maintained because of our history of respect for their value and an enduring commitment to their vigilant protection...
Authors
Patricia R. Bright, Herbert T. Buxton, Laurie S. Balistrieri, Larry B. Barber, Francis H. Chapelle, Paul C. Cross, David P. Krabbenhoft, Geoffrey S. Plumlee, Jonathan M. Sleeman, Donald E. Tillitt, Patricia L. Toccalino, James R. Winton
Thiamine deficiency: a viable hypothesis for paralytic syndrome in Baltic birds. Commentary on Sonne et al., 2012. A review of the factors causing paralysis in wild birds: implications for the paralytic syndrome observed in the Baltic Sea. Science of t Thiamine deficiency: a viable hypothesis for paralytic syndrome in Baltic birds. Commentary on Sonne et al., 2012. A review of the factors causing paralysis in wild birds: implications for the paralytic syndrome observed in the Baltic Sea. Science of t
In a recent assessment of hypotheses presented by Balk et al. (2009) regarding the etiology of a paralytic disease inflicting bird populations in Northern Europe, Sonne et al. (2012) “call for a major coordinated effort on research…” to “… integrate clinical, physiological, ecological and demographic investigations at all levels to better dissect the causes, the effects on ecosystems and...
Authors
Donald E. Tillitt, Clifford E. Kraft, Dale C. Honeyfield, John D. Fitzsimons
Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development Identification of the thiamin pyrophosphokinase gene in rainbow trout: Characteristic structure and expression of seven splice variants in tissues and cell lines and during embryo development
Thiamin pyrophosphokinase (TPK) converts thiamin to its active form, thiamin diphosphate. In humans, TPK expression is down-regulated in some thiamin deficiency related syndrome, and enhanced during pregnancy. Rainbow trout are also vulnerable to thiamin deficiency in wild life and are useful models for thiamin metabolism research. We identified the tpk gene transcript including seven...
Authors
Shinya Yuge, Catherine A. Richter, Maureen K. Wright-Osment, Diane Nicks, Stephanie K. Saloka, Donald E. Tillitt, Weiming Li
Paenibacillus thiaminolyticus is not the cause of thiamine deficiency impeding lake trout (Salvelinus namaycush) recruitment in the Great Lakes Paenibacillus thiaminolyticus is not the cause of thiamine deficiency impeding lake trout (Salvelinus namaycush) recruitment in the Great Lakes
Thiamine (vitamin B1) deficiency is a global concern affecting wildlife, livestock, and humans. In Great Lakes salmonines, thiamine deficiency causes embryo mortality and is an impediment to restoration of native lake trout (Salvelinus namaycush) stocks. Thiamine deficiency in fish may result from a diet of prey with high levels of thiaminase I. The discoveries that the bacterial species
Authors
Catherine A. Richter, Allison N. Evans, Maureen K. Wright-Osment, James L. Zajicek, Scott A. Heppell, Stephen C. Riley, Charles C. Krueger, Donald E. Tillitt
*Disclaimer: Listing outside positions with professional scientific organizations on this Staff Profile are for informational purposes only and do not constitute an endorsement of those professional scientific organizations or their activities by the USGS, Department of the Interior, or U.S. Government