Donald Tillitt, PhD (Former Employee)

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February 8, 2019

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...

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Ecosystems Mission Area, Species Management Research Program, Columbia Environmental Research Center

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

February 8, 2019

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...

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January 1, 2003

In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes). In ovo exposure to o,p -DDE affects sexual development but not sexual differentiation in Japanese medaka (Oryzias latipes).

Despite being banned in many countries, dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) continue to be found in fish tissues at concentrations of concern. Like o,p -DDT, o,p -DDE is estrogenic and is believed to exert its effects through binding to the estrogen receptor. The limited toxicologic data...

Authors

D. M. Papoulias, Sergio A. Villalobos, J. Meadows, Douglas B. Noltie, J. P. Giesy, D. E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 2003

Comparison of prehatch C-start responses in rainbow trout and lake trout embryos by means of a tactile stimulus test Comparison of prehatch C-start responses in rainbow trout and lake trout embryos by means of a tactile stimulus test

The C-start in teleost fishes, a type of startle response, mediates the ability to respond to abrupt, unexpected stimuli and is characterized by a short-latency, C-type fast start acceleration. In prehatch fish embryos, the C-start appears necessary for mechanical breakdown of the egg chorion and successful hatching by way of increased embryo movement and distribution of the hatching...

Authors

P.J. Wright, Douglas B. Noltie, D. E. Tillitt

January 1, 2003

Determination of PCBs in fish using enzyme-linked immunosorbent assay (ELISA) Determination of PCBs in fish using enzyme-linked immunosorbent assay (ELISA)

Polychlorinated biphenyls (PCBs) were determined in fish tissue using an enzyme-linked immunosorbent assay (ELISA). Standard curves for Aroclor 1248, 1254, and 1260 in catfish tissue were developed with ranges from 0.05 to 0.5 ppm and 0.5 to 5.0 ppm. Wild fish were initially analyzed using gas chromatography/electron-capture detection (GC/ECD) and those having residues within the...

Authors

J.A. Lasrado, C.R. Santerre, J.L. Zajicek, J.R. Stahl, D. E. Tillitt, D. Deardorff

January 1, 2003

Workshop 3.5: Closing the gap between exposure and effects in monitoring studies Workshop 3.5: Closing the gap between exposure and effects in monitoring studies

A major challenge to contaminant monitoring programs is the selection of an appropriate suite of measurements for assessing exposure and effects. Early monitoring programs relied solely on residue analysis to detect the organochlorine compounds that were in use at that time. A shift to the use of more transient, less persistent chemicals required that a new set of tools be developed to...

Authors

Donald E. Tillitt, Diana M. Papoulias

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 2003

Toxicity of o,p′-DDE to medaka d-rR strain after a one-time embryonic exposure by in ovo nanoinjection: An early through juvenile life cycle assessment Toxicity of o,p′-DDE to medaka d-rR strain after a one-time embryonic exposure by in ovo nanoinjection: An early through juvenile life cycle assessment

The toxicity of o,p′-DDE (1,1-dichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethylene) was evaluated in embryos of medaka (Oryzias latipes) following a one time exposure via nanoinjection. Medaka eggs (early gastrula) were injected with 0.5 nl of triolein (vehicle control) or 0.5 nl of 4 graded doses (0.0005-0.5 ng/egg) of o,p′-DDE in triolein. Embryos were allowed to develop, and fry...

Authors

Sergio A. Villalobos, Diana M. Papoulias, Stephanie D. Pastva, Alan L. Blankenship, John C. Meadows, Donald E. Tillitt, John P. Giesy

July 18, 2002

Effects of chronic dietary exposure to environmentally relevant concentrations to 2,3,7,8-tetrachlorodibenzo-p-dioxin on survival, growth, reproduction and biochemical responses of female rainbow trout (Oncorhynchus mykiss) Effects of chronic dietary exposure to environmentally relevant concentrations to 2,3,7,8-tetrachlorodibenzo-p-dioxin on survival, growth, reproduction and biochemical responses of female rainbow trout (Oncorhynchus mykiss)

Adult female rainbow trout were exposed to dietary 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at concentrations of 1.8, 18 and 90 ng TCDD/kg (ww) food for up to 300 day. At the end of the exposure fish were spawned and the reproductive outcomes were assessed. TCDD was accumulated into tissues and eggs in a dose-dependent manner with steady state being achieved after 50–100 day of...

Authors

John P. Giesy, Paul D. Jones, Kurunthachalam Kannan, John L. Newsted, Donald E. Tillitt, Lisa L. Williams

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 2002

2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Zebrafish Embryo: Local Circulation Failure in the Dorsal Midbrain Is Associated with Increased Apoptosis

No abstract available.

Authors

Donald E. Tillitt, Diana M. Papoulias

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 2002

Ontogenetic improvement of visual function in the medaka Oryzias latipes based on an optomotor testing system for larval and adult fish Ontogenetic improvement of visual function in the medaka Oryzias latipes based on an optomotor testing system for larval and adult fish

We developed a system for evaluation of visual function in larval and adult fish. Both optomotor (swimming) and optokinetic (eye movement) responses were monitored and recorded using a system of rotating stripes. The system allowed manipulation of factors such as width of the stripes used, rotation speed of the striped drum, and light illuminance levels within both the scotopic and...

Authors

Paulo S. M. Carvalho, Douglas B. Noltie, D. E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 2002

Project summary, discussion, and recommendations Project summary, discussion, and recommendations

No abstract available at this time

Authors

C. J. Schmitt, D. E. Tillitt, V. S. Blazer, T. S. Gross, N. D. Denslow, T.M. Bartish, B.S. Arnold

By

Ecosystems Mission Area, Eastern Ecological Science Center

January 1, 2002

Project Overview Project Overview

No abstract available at this time

Authors

C. J. Schmitt, D. E. Tillitt, G.M. Dethloff, T.M. Bartish, V. S. Blazer, T. S. Gross, B. E. Wright

By

Ecosystems Mission Area, Eastern Ecological Science Center

December 31, 2001

Regulation of subcellular localization of the Aryl Hydrocarbon Receptor (AhR) Regulation of subcellular localization of the Aryl Hydrocarbon Receptor (AhR)

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxicity of dioxin and other xenobiotics. In the absence of exogenous ligand, AhR is cytosolic. We investigated how AhR is retained in the cytosol and how dioxin induces AhR to move to the nucleus. Disruption of nuclear export of AhR by the nuclear export inhibitor leptomycin B (LMB) or by...

Authors

Cathy A. Richter, Donald E. Tillitt, Mark Hannink

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 2001

Cytochrome P450 1A expression in midwater fishes: Potential effects of chemical contaminants in remote oceanic zones Cytochrome P450 1A expression in midwater fishes: Potential effects of chemical contaminants in remote oceanic zones

Cytochrome P450 1A (CYP1A) induction is a robust marker for exposure to polynuclear aromatic hydrocarbons and planar halogenated aromatic hydrocarbons that are aryl hydrocarbon receptor agonists. We examined CYP1A expression in mesopelagic fishes from the western North Atlantic. Individuals in 22 species were obtained from slope water and the Sargasso Sea in 1977, 1978, and 1993. Aryl...

Authors

John J. Stegeman, Jennifer J. Schlezinger, James E. Craddock, Donald E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

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