Donald Tillitt, PhD (Former Employee)

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February 8, 2019

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...

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Ecosystems Mission Area, Species Management Research Program, Columbia Environmental Research Center

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

February 8, 2019

Thiamine (Vitamin B1) Deficiency in Fish and Wildlife

In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...

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January 1, 1997

Carrier effects of dosing the h4iie cells with 3,3′,4,4tt´etrachlorobiphenyl (PCB77) in dimethyl sulfoxide or isooctane Carrier effects of dosing the h4iie cells with 3,3′,4,4tt´etrachlorobiphenyl (PCB77) in dimethyl sulfoxide or isooctane

A rat hepatoma cell line, H4IIE serves as a bioassay tool to assess the potential toxicity of dioxin-like chemicals, including polychlorinated biphenyls (PCB) in environmental samples. PCB exposure to these cells induces cytochrome (CYP) P4501A1 activity in a dose-dependent fashion, thus allowing assessment of mixtures. The objective of this study was to determine the effect of different...

Authors

Kyung O. Yu, Jeff W. Fisher, G. Allen Burton, Donald E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

December 1, 1996

In vivo/in vitro comparison of pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77) In vivo/in vitro comparison of pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77)

The rat hepatoma cell line, H4IIE, serves as a useful tool to assess potential biological effects such as induction of cytochrome P4501A1 expression. The objectives of this study were twofold: to investigate the kinetic time course and dosimetry of PCB77 in rat hepatoma cells dosed with PCB77 and in liver of rats given ip doses of PCB77, and to comparein vitroandin vivoP4501A1 enzyme...

Authors

Kyung O. Yu, Donald E. Tillitt, Janusz Z. Byczkowski, G. Allen Burton, Stephen R. Channel, Joanne M. Drerup, Carlyle D. Flemming, Jeffrey W. Fisher

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Ecosystems Mission Area, Columbia Environmental Research Center

July 18, 1996

Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Theembryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes) Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Theembryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes)

Vertebrate embryos are extremely sensitive to environmental contaminants known as planar halogenated hydrocarbons (PHHs). The physiological targets that mediate PHH-induced embryotoxicity are not known. We have characterized embryotoxicity in medaka (Orizias latipes) caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the prototypic PHH. DNA degradation in cells of the embryonic...

Authors

Susannah M. Cantrell, Linda H. Lutz, Donald E. Tillitt, Mark Hannink

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Ecosystems Mission Area, Columbia Environmental Research Center

July 18, 1996

Application of enzyme-linked immunosorbent assay for measurement of polychlorinated biphenyls from hydrophobic solutions: Extracts of fish and dialysates of semipermeable membrane devices: Chapter 26 Application of enzyme-linked immunosorbent assay for measurement of polychlorinated biphenyls from hydrophobic solutions: Extracts of fish and dialysates of semipermeable membrane devices: Chapter 26

Determination of PCBs in biological tissue extracts by enzyme-linked immunosorbent assays (ELISAs) can be problematic, since the hydrophobic solvents used for their extraction and isolation from interfering biochemicals have limited compatibility with the polar solvents (e.g. methanol/water) and the immunochemical reagents used in ELISA. Our studies of these solvent effects indicate that

Authors

James L. Zajicek, Donald E. Tillitt, James N. Huckins, Jimmie D. Petty, Michael E. Potts, David A. Nardone

By

Ecosystems Mission Area, Columbia Environmental Research Center

July 11, 1996

Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation Effects of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) injected into the yolks of chicken (Gallus domesticus) eggs prior to incubation

The yolks of White Leghorn chicken (Gallus domesticus) eggs were injected prior to incubation with either 3,3′,4,4′,5- pentachlorobiphenyl (PCB 126) at doses ranging from 0.1 to 12.8 μg/kg egg or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at doses ranging from 0.04 to 0.64 μg/kg egg. Chicks were subjected to necropsy within 24 h of hatching. The brain, bursa, heart, liver, and spleen...

Authors

D.C. Powell, R.J. Aulerich, J.C. Meadows, D. E. Tillitt, J. P. Giesy, K. L. Stromborg, S.J. Bursian

By

Ecosystems Mission Area, Columbia Environmental Research Center

June 11, 1996

Organochlorine contaminants in double-crested cormorants from Green Bay, WI: I. Large-scale extraction and isolation from eggs using semi-permeable membrane dialysis Organochlorine contaminants in double-crested cormorants from Green Bay, WI: I. Large-scale extraction and isolation from eggs using semi-permeable membrane dialysis

A 41.3-kg sample of double-crested cormorant (Phalacrocorax auritus) egg contents was extracted, yielding over 2 L of egg lipid. The double-crested cormorant (DCC) egg extract, after clean-up and concentration, was intended for use in egg injection studies to determine the embryotoxicity of the organic contaminants found within the eggs. Large-scale dialysis was used as a preliminary...

Authors

J.C. Meadows, D. E. Tillitt, T.R. Schwartz, D.J. Schroeder, K. R. Echols, R.W. Gale, D.C. Powell, S.J. Bursian

By

Ecosystems Mission Area, Columbia Environmental Research Center

June 11, 1996

Rainbow trout embryotoxicity of a complex contaminant mixture extracted from Lake Michigan lake trout Rainbow trout embryotoxicity of a complex contaminant mixture extracted from Lake Michigan lake trout

Persistent Hydrophobic contaminants such as poly chlorinated dibenzo-p-dioxins, dibenzofurans and biphenyl congeners are present in aquatic systems, and are known to produce adverse effects in fish. Reproductive failure in fish populations has been observed in aquatic systems contaminated with persistent hydrophobic compounds. In order to mimic maternal transfer of environmental...

Authors

Penelope J. Wilson, D. E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

May 13, 1996

Optimization of the Ames/salmonella mutagenicity assay for use with extracts of aquatic sediments Optimization of the Ames/salmonella mutagenicity assay for use with extracts of aquatic sediments

Non-mutagenic components interfered with the ability of the standard Ames/salmonella assay to detect mutagenicity in extracts of contaminated Great Lakes sediments. The use of gel permeation chromatography (GPC) to remove these macromolecules from methylene chloride extracts prior to Ames testing enhanced the likelihood of transfer of mutagenic components into dimethyl sulf oxide (the...

Authors

Diana M. Papoulias, Denny R. Buckler, Donald E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

May 13, 1996

Fish egg injection as an alternative exposure route for early life stage toxicity studies: Description of two unique methods: Chapter 4 Fish egg injection as an alternative exposure route for early life stage toxicity studies: Description of two unique methods: Chapter 4

In the environment, lipophilic contaminants such as halogenated aromatic hydrocarbons (HAHs, e.g., polychlorinated biphenyls, PCBs) and polycyclic aromatic hydrocarbons (PAHs, e.g., benzo[a]pyrene) readily bioaccumulate in fish, and the bioaccumulation of these lipophilic chemicals by adult fish may have significant consequences on the development and survival of their offspring...

Authors

Mary K. Walker, Erik W. Zabel, Gun Akerman, Lennart Balk, Peggy J. Wright, Donald E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 1996

Deformities, PCBs, and TCDD-equivalents in double-crested cormorants (Phalacrocorax auritus) and Caspian terns (Hydroprogne caspia) of the Upper Great Lakes 1986–1991: Testing a cause-effect hypothesis Deformities, PCBs, and TCDD-equivalents in double-crested cormorants (Phalacrocorax auritus) and Caspian terns (Hydroprogne caspia) of the Upper Great Lakes 1986–1991: Testing a cause-effect hypothesis

Deformities have been reported in many species of colonial waterbirds from several localities on the Laurentian Great Lakes. The hypothesis that deformities were caused by either polychlorinated biphenyls (PCBs) or contaminants measured as 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQs) is tested in this review of available data on concentrations of contaminants in eggs and...

Authors

James P. Ludwig, Hiroko Kurita-Matsuba, Heidi J. Auman, Matthew E. Ludwig, Cheryl L. Summer, John P. Giesy, Donald E. Tillitt, Paul D. Jones

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 1996

Analysis of non-ortho-PCBs in fish, bird eggs, sediments, soils, and SPMD samples by gas chromatography/high resolution mass spectrometry: Chapter 27 Analysis of non-ortho-PCBs in fish, bird eggs, sediments, soils, and SPMD samples by gas chromatography/high resolution mass spectrometry: Chapter 27

No abstract available.

Authors

Paul H. Peterman, Robert W. Gale, Donald E. Tillitt, Kevin P. Feltz

By

Ecosystems Mission Area, Columbia Environmental Research Center

January 1, 1996

Comparison of the uptake of dioxin-like compounds by caged channel catfish and semipermeable membrane devices in the Saginaw River, Michigan Comparison of the uptake of dioxin-like compounds by caged channel catfish and semipermeable membrane devices in the Saginaw River, Michigan

Elevated concentrations of planar, halogenated hydrocarbons have been linked to reproductive problems in a variety of fish-eating birds and mammals in the Great Lakes and in particular Saginaw Bay. Currently, there are no accurate procedures to assess bioavailability of these contaminants. Polychlorinated dibenzo-p-dioxins and dibenzofurans and mono- and non-ortho-chloro-substituted...

Authors

Robert W. Gale, James N. Huckins, Jimmie D. Petty, Paul H. Peterman, Lisa L. Williams, Douglas Morse, Ted R. Schwartz, Donald E. Tillitt

By

Ecosystems Mission Area, Columbia Environmental Research Center

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