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Below is a list of available Fish Health Program peer reviewed and published science.

Filter Total Items: 323

A new sturgeon herpesvirus from juvenile Lake Sturgeon Acipenser fulvescens displaying epithelial skin lesions

Herpesvirus infections of sturgeon pose a potential threat to sturgeon culture efforts worldwide. A new epitheliotropic herpesvirus named Acipenser herpesvirus 3 (AciHV-3) was detected in hatchery-reared Lake Sturgeon Acipenser fulvescens displaying skin lesions in central Canada. The growths were discovered in the fall, reached average prevalence levels of 0.2–40% and eventually regressed. No unu
Sharon Clouthier, Marek Tomczyk, Tamara Schroeder, Cheryl Klassen, André Dufresne, Eveline J. Emmenegger, Thomas Nalpathamkalam, Zhuozhi Wang, Bhooma Thiruvahindrapuram

Tire-derived transformation product 6PPD-quinone induces mortality and transcriptionally disrupts vascular permeability pathways in developing coho salmon

Urban stormwater runoff frequently contains the car tire transformation product 6PPD-quinone, which is highly toxic to juvenile and adult coho salmon (Onchorychus kisutch). However, it is currently unclear if embryonic stages are impacted. We addressed this by exposing developing coho salmon embryos starting at the eyed stage to three concentrations of 6PPD-quinone twice weekly until hatch. Impact
Justin Blaine Greer, Ellie Maureen Dalsky, Rachael F. Lane, John Hansen

Susceptibility of Pallid Sturgeon to viral hemorrhagic septicemia virus genotype IVb

ObjectiveViral hemorrhagic septicemia virus (VHSV) is an aquatic rhabdovirus causing severe disease in freshwater and saltwater fish species. The susceptibility of endangered Pallid Sturgeon Scaphirhynchus albus to VHSV genotype IVb (VHSV-IVb) infection was investigated.MethodsAn in vitro assessment using two Pallid Sturgeon cell lines derived from skin and spleen tissue and in vivo evaluation of
Lacey R. Hopper, Jolene A. Glenn, Elizabeth MacConnell, James Winton, Eveline J. Emmenegger

Establishing an in vitro model to assess the toxicity of 6PPD-quinone and other tire wear transformation products

The tire wear transformation product 6PPD-quinone (6PPDQ) has been implicated as the causative factor for broad scale mortality events for coho salmon in the Pacific Northwest. Highly variable sensitivity to 6PPDQ in closely related salmonids complicates efforts to evaluate the broader toxicological impacts to aquatic ecosystems. Our goals were to (1) validate the large range of in vivo species se
Justin Blaine Greer, Ellie Maureen Dalsky, Rachael F. Lane, John Hansen

Characterization of maternal immunity following vaccination of broodstock against IHNV or Flavobacterium psychrophilum in rainbow trout (Oncorhynchus mykiss)

Infectious hematopoietic necrosis (IHN) is a significant viral disease affecting salmonids, whereas Flavobacterium psychrophilum (Fp), the causative agent of bacterial coldwater disease (BCWD), remains one of the most significant bacterial pathogens of salmonids. We explored maternal immunity in the context of IHN and BCWD management in rainbow trout (Oncorhynchus mykiss) aquaculture. Two experime
Jie Ma, Jesse T. Trushenski, Evan M. Jones, Timothy J. Bruce, Doug G. McKenney, Gael Kurath, Kenneth D. Cain

Coproduction and modeling spatial contact networks prevent bias about infectious hematopoietic necrosis virus transmission for Snake River Basin salmonids

Much remains unknown about variation in pathogen transmission across the geographic range of a free-ranging fish or animal species and about the influence of movement (associated with husbandry practices or animal behavior) on pathogen transmission. Salmonid hatcheries are an ideal system in which to study these processes. Salmonid hatcheries are managed for endangered species recovery, supplement
Jeffrey P. Mattheiss, Rachel Breyta, Gael Kurath, Shannon L. LaDeau, David James Páez, Paige F. B. Ferguson

Exposure to 17α-ethinylestradiol results in differential susceptibility of largemouth bass (Micropterus salmoides) to bacterial infection

Disease outbreaks, skin lesions, mortality events, and reproductive abnormalities have been observed in wild populations of centrarchids. The presence of estrogenic endocrine disrupting compounds (EEDCs) has been implicated as a potential causal factor for these effects. The effects of prior EEDC exposure on immune response were examined in juvenile largemouth bass (Micropterus salmoides) exposed
Jessica Kristin Leet, Justin Greer, Cathy A. Richter, Luke R. Iwanowicz, Edward Spinard, Jacquelyn McDonald, Carla M. Conway, Robert W. Gale, Donald E. Tillitt, John Hansen

Comparative susceptibilities of selected California Chinook salmon and steelhead populations to isolates of L Genogroup Infectious Hematopoietic Necrosis Virus (IHNV)

Salmonid species demonstrate varied susceptibility to the viral pathogen infectious hematopoietic necrosis virus (IHNV). In California conservation hatcheries, juvenile Chinook salmon (Oncorhynchus tshawytscha) have experienced disease outbreaks due to L genogroup IHNV since the 1940s, while indigenous steelhead (anadromous O. mykiss) appear relatively resistant. To characterize factors contributi
Christin M. Bendorf, Susan C. Yun, Gael Kurath, Ronald P. Hedrick

Brief oil exposure reduces fitness in wild Gulf of Mexico mahi-mahi (Coryphaena hippurus)

The Deepwater Horizon (DWH) disaster released 3.19 million barrels of crude oil into the Gulf of Mexico (GOM) in 2010, overlapping the habitat of pelagic fish populations. Using mahi-mahi (Coryphaena hippurus)─a highly migratory marine teleost present in the GOM during the spill─as a model species, laboratory experiments demonstrate injuries to physiology and behavior following oil exposure. Howev
Lela S. Schlenker, John D. Stieglitz, Justin Blaine Greer, Robin Faillettaz, Chi Hin Lam, Ronald H. Hoenig, Rachael M. Heuer, Charles J. McGuigan, Christina Pasparakis, Emma B. Esch, Gabrielle M. Ménard, Alexandra L. Jaroszewski, Claire B. Paris, Daniel Schlenk, Daniel D. Benetti, Martin Grosell

Evaluating the effect of nuclear inclusion X (NIX) infections on Pacific razor clam populations

ABSTRACT: Nuclear inclusion X (NIX), the etiological agent of bacterial gill disease in Pacific razor clams Siliqua patula, was associated with host mortality events in coastal Washington State, USA, during the mid-1980s. Ongoing observations of truncated razor clam size distributions in Kalaloch Beach, Washington, raised concerns that NIX continues to impact populations. We conducted a series of
Maya Groner, Paul Hershberger, Steven C. Fradkin, Carla M. Conway, Aine C. Hawthorn, Maureen K. Purcell

Variation in within-host replication kinetics among virus genotypes provides evidence of specialist and generalist infection strategies across three salmonid host species

Theory of the evolution of pathogen specialization suggests that a specialist pathogen gains high fitness in one host, but this comes with fitness loss in other hosts. By contrast, a generalist pathogen does not achieve high fitness in any host, but gains ecological fitness by exploiting different hosts, and has higher fitness than specialists in nonspecialized hosts. As a result, specialist patho
David James Páez, Douglas G. McKenney, Maureen K. Purcell, Kerry A. Naish, Gael Kurath

Evaluation of Francisella orientalis ΔpdpA as a live attenuated vaccine against piscine Francisellosis in Nile tilapia

Francisella orientalis is an important bacterial pathogen of marine and freshwater fish with worldwide distribution. Fish francisellosis is a severe subacute to chronic granulomatous disease, with high mortalities and high infectivity rates in cultured and wild fish. To date, there is no approved vaccine for this disease. In this study, we evaluated the efficacy of a defined F. orientalis pathogen
Fernanda de Alexandre Sebastião, John Hansen, Esteban Soto