Donald Tillitt, PhD (Former Employee)
Science and Products
Thiamine (Vitamin B1) Deficiency in Fish and Wildlife
In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...
Filter Total Items: 14
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Filter Total Items: 217
Reproductive success, developmental anomalies and environmental contaminants in double-crested cormorants (Phalacrocorax auritus) Reproductive success, developmental anomalies and environmental contaminants in double-crested cormorants (Phalacrocorax auritus)
To test an association between environmental contaminants and the prevalence of congenital anomalies in colonial waterbirds, we collected representative eggs for chemical analysis from double-crested cormorant nests at colonies in Lake Michigan, Wisconsin, USA, and Lake Winnipegosis, Manitoba, Canada, and periodically revisited the nests to determine the hatching success, survivorship of...
Authors
J. M. Larson, W. H. Karasov, L. Sileo, K. L. Stromborg, B. A. Hanbidge, J. P. Giesy, P. D. Jones, D. E. Tillitt, D. A. Verbrugge
Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology
The effects of consumption of environmental contaminants contained in carp (Cyprinus carpio)from Saginaw Bay, Michigan on various hematological parameters and liver integrity of adult female mink (Mustela vison) were determined. Mink were fed diets that contained 0 (control), 10, 20, or 40% carp prior to and throughout the reproductive period (182 days). The diets contained 0.015, 0.72...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Contaminants in fishes from great lakes-influenced sections and above dams of three Michigan Rivers: III. Implications for health of bald eagles Contaminants in fishes from great lakes-influenced sections and above dams of three Michigan Rivers: III. Implications for health of bald eagles
Recently, there have been discussions of the relative merits of passage of fishes around hydroelectric dams on three rivers (Au Sable, Manistee, and Muskegon) in Michigan. A hazard assessment was conducted to determine the potential for adverse effects on bald eagles that could consume such fishes from above and below dams on the three primary rivers. The hazard assessments were verified...
Authors
J. P. Giesy, W.W. Bowerman, M.A. Mora, D. A. Verbrugge, R. A. Othoudt, J.L. Newsted, C. L. Summer, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout
This study was undertaken to evaluate the relationship between mammalian and piscine 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalency factors (TEFs) for PCBs, based on induction of CYP1A enzyme activity, catalytic protein, and mRNA. Rainbow trout administered a single i.p. injection of TCDD had an average (±SD) ED50 of 0.91 ± 0.14 μg TCDD/kg for induction of ethoxyresorufin O
Authors
John L. Newsted, Paul D. Jones, John P. Giesy, Robert A. Crawford, Gerald T. Ankley, Donald E. Tillitt, Jay W. Gooch, Michael S. Denison
Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations
Carp (Cyprinus carpio) collected from Saginaw Bay, Michigan, containing 8.4 mg total polychlorinated biphenyls (PCBs)/kg and 194 ng of 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents (TEQs)/kg, were substituted for marine fish at levels of 0, 10, 20, or 40% in the diets of adult ranch mink (Mustela vison). The diets, containing 0.015, 0.72, 1.53, and 2.56 mg PCBs/kg diet, or 1.03, 19.41...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations
Semipermeable membrane devices (SPMDs) were used to passively sample aqueous polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in Bayou Meto, AR. The two sites were upstream and downstream from the confluence with a tributary that delivers PCDDs and PCDFs to the Bayou. Following dialysis, cleanup, and fractionation, four replicate 17-9 SPMD samples from...
Authors
Jon A. Lebo, Robert W. Gale, Jimmie D. Petty, Donald E. Tillitt, James N. Huckins, John C. Meadows, Carl E. Orazio, Kathy R. Echols, Dennis J. Schroeder, Lloyd E. Inmon
Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification
Mink are known to be very sensitive to the toxic effects of planar polychlorinated biphenyls (pPCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), collectively known as planar halogenated hydrocarbons (PHHs). Previously, we reported the reproductive effects in mink fed a diet containing 10, 20, or 40% fish taken from Saginaw Bay, Lake Huron. The...
Authors
Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajicek, Paul H. Peterman, Silvia N. Heaton, Paul D. Jones, Steven J. Bursian, Timothy J. Kubiak, John P. Giesy, Richard J. Aulerich
Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon
No abstract available.
Authors
Kevin P. Feltz, Donald E. Tillitt, Robert W. Gale, Paul H. Peterman
Deformities in birds of the Great Lakes region. Assigning causality Deformities in birds of the Great Lakes region. Assigning causality
No abstract available.
Authors
John P. Giesy, James P. Ludwig, Donald E. Tillitt
Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds
No abstract available.
Authors
J. P. Giesy, J. P. Ludwig, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury
Fishes of the Great Lakes contain hazardous chemicals such as synthetic halogenated hydrocarbons and metals. These fish can move from the lakes into the Great Lakes tributaries of Michigan. In doing so, they transport concentrationsof contaminants which may represent a risk to wildlife. Concentrations of mercury (Hg), total polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, M. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink
Populations of mink (Mustela vison) have declined in many areas of the world. Such declines have been linked to exposures to synthetic, halogenated hydrocarbons. In the Great Lakes region, mink are fewer in areas along the shore of the Great Lakes and their tributaries where mink have access to fish from the Great Lakes. Recently, there has been discussion of the relative merits of...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Science and Products
Thiamine (Vitamin B1) Deficiency in Fish and Wildlife
In the last few decades, thiamine deficiency has been observed in fish and wildlife in the Great Lakes, Alaska, Sweden and several other areas in North America and Europe. Thiamine is an essential vitamin needed for cell function. Thiamine deficiency has been linked to neurological disorders, immunosuppression, and lower reproductive viability. These disorders potentially reduce populations of...
Filter Total Items: 14
No Result Found
Filter Total Items: 217
Reproductive success, developmental anomalies and environmental contaminants in double-crested cormorants (Phalacrocorax auritus) Reproductive success, developmental anomalies and environmental contaminants in double-crested cormorants (Phalacrocorax auritus)
To test an association between environmental contaminants and the prevalence of congenital anomalies in colonial waterbirds, we collected representative eggs for chemical analysis from double-crested cormorant nests at colonies in Lake Michigan, Wisconsin, USA, and Lake Winnipegosis, Manitoba, Canada, and periodically revisited the nests to determine the hatching success, survivorship of...
Authors
J. M. Larson, W. H. Karasov, L. Sileo, K. L. Stromborg, B. A. Hanbidge, J. P. Giesy, P. D. Jones, D. E. Tillitt, D. A. Verbrugge
Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology Dietary exposure of mink to carp from Saginaw Bay, Michigan: 2. Hematology and liver pathology
The effects of consumption of environmental contaminants contained in carp (Cyprinus carpio)from Saginaw Bay, Michigan on various hematological parameters and liver integrity of adult female mink (Mustela vison) were determined. Mink were fed diets that contained 0 (control), 10, 20, or 40% carp prior to and throughout the reproductive period (182 days). The diets contained 0.015, 0.72...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Contaminants in fishes from great lakes-influenced sections and above dams of three Michigan Rivers: III. Implications for health of bald eagles Contaminants in fishes from great lakes-influenced sections and above dams of three Michigan Rivers: III. Implications for health of bald eagles
Recently, there have been discussions of the relative merits of passage of fishes around hydroelectric dams on three rivers (Au Sable, Manistee, and Muskegon) in Michigan. A hazard assessment was conducted to determine the potential for adverse effects on bald eagles that could consume such fishes from above and below dams on the three primary rivers. The hazard assessments were verified...
Authors
J. P. Giesy, W.W. Bowerman, M.A. Mora, D. A. Verbrugge, R. A. Othoudt, J.L. Newsted, C. L. Summer, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout
This study was undertaken to evaluate the relationship between mammalian and piscine 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxic equivalency factors (TEFs) for PCBs, based on induction of CYP1A enzyme activity, catalytic protein, and mRNA. Rainbow trout administered a single i.p. injection of TCDD had an average (±SD) ED50 of 0.91 ± 0.14 μg TCDD/kg for induction of ethoxyresorufin O
Authors
John L. Newsted, Paul D. Jones, John P. Giesy, Robert A. Crawford, Gerald T. Ankley, Donald E. Tillitt, Jay W. Gooch, Michael S. Denison
Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations Dietary exposure of mink to carp from Saginaw Bay, Michigan. 1. Effects on reproduction and survival, and the potential risks to wild mink populations
Carp (Cyprinus carpio) collected from Saginaw Bay, Michigan, containing 8.4 mg total polychlorinated biphenyls (PCBs)/kg and 194 ng of 2,3,7,8-tetrachloro-dibenzo-p-dioxin equivalents (TEQs)/kg, were substituted for marine fish at levels of 0, 10, 20, or 40% in the diets of adult ranch mink (Mustela vison). The diets, containing 0.015, 0.72, 1.53, and 2.56 mg PCBs/kg diet, or 1.03, 19.41...
Authors
S. N. Heaton, S.J. Bursian, J. P. Giesy, D. E. Tillitt, J. A. Render, P. D. Jones, D. A. Verbrugge, T.J. Kubiak, R.J. Aulerich
Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations Use of the semipermeable membrane device as an in situ sampler of waterborne bioavailable PCDD and PCDF residues at sub-parts-per-quadrillion concentrations
Semipermeable membrane devices (SPMDs) were used to passively sample aqueous polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in Bayou Meto, AR. The two sites were upstream and downstream from the confluence with a tributary that delivers PCDDs and PCDFs to the Bayou. Following dialysis, cleanup, and fractionation, four replicate 17-9 SPMD samples from...
Authors
Jon A. Lebo, Robert W. Gale, Jimmie D. Petty, Donald E. Tillitt, James N. Huckins, John C. Meadows, Carl E. Orazio, Kathy R. Echols, Dennis J. Schroeder, Lloyd E. Inmon
Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification Dietary exposure of mink to carp from Saginaw Bay. 3. Characterization of dietary exposure to planar halogenated hydrocarbons, dioxin equivalents, and biomagnification
Mink are known to be very sensitive to the toxic effects of planar polychlorinated biphenyls (pPCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs), collectively known as planar halogenated hydrocarbons (PHHs). Previously, we reported the reproductive effects in mink fed a diet containing 10, 20, or 40% fish taken from Saginaw Bay, Lake Huron. The...
Authors
Donald E. Tillitt, Robert W. Gale, John C. Meadows, James L. Zajicek, Paul H. Peterman, Silvia N. Heaton, Paul D. Jones, Steven J. Bursian, Timothy J. Kubiak, John P. Giesy, Richard J. Aulerich
Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon Automated HPLC fractionation of PCDDs and PCDFs and planar and nonplanar PCBs on C18-dispersed PX-21 carbon
No abstract available.
Authors
Kevin P. Feltz, Donald E. Tillitt, Robert W. Gale, Paul H. Peterman
Deformities in birds of the Great Lakes region. Assigning causality Deformities in birds of the Great Lakes region. Assigning causality
No abstract available.
Authors
John P. Giesy, James P. Ludwig, Donald E. Tillitt
Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds
No abstract available.
Authors
J. P. Giesy, J. P. Ludwig, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. I: Concentrations of organo chlorine insecticides, polychlorinated biphenyls, dioxin equivalents, and mercury
Fishes of the Great Lakes contain hazardous chemicals such as synthetic halogenated hydrocarbons and metals. These fish can move from the lakes into the Great Lakes tributaries of Michigan. In doing so, they transport concentrationsof contaminants which may represent a risk to wildlife. Concentrations of mercury (Hg), total polychlorinated biphenyls (PCBs), 2,3,7,8-tetrachlorodibenzo-p...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, M. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink Contaminants in fishes from Great Lakes-influenced sections and above dams of three Michigan rivers. II: Implications for health of mink
Populations of mink (Mustela vison) have declined in many areas of the world. Such declines have been linked to exposures to synthetic, halogenated hydrocarbons. In the Great Lakes region, mink are fewer in areas along the shore of the Great Lakes and their tributaries where mink have access to fish from the Great Lakes. Recently, there has been discussion of the relative merits of...
Authors
J. P. Giesy, D. A. Verbrugge, R. A. Othout, W.W. Bowerman, M.A. Mora, P. D. Jones, J.L. Newsted, C. Vandervoort, S. N. Heaton, R.J. Aulerich, S.J. Bursian, J. P. Ludwig, G. A. Dawson, T.J. Kubiak, D. A. Best, D. E. Tillitt
*Disclaimer: Listing outside positions with professional scientific organizations on this Staff Profile are for informational purposes only and do not constitute an endorsement of those professional scientific organizations or their activities by the USGS, Department of the Interior, or U.S. Government