Donald Tillitt, PhD (Former Employee)
Science and Products
Filter Total Items: 215
Accumulation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents by double-crested cormorant (Phalacrocorax auritus, Pelicaniformes) chicks in the North American Great Lakes Accumulation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents by double-crested cormorant (Phalacrocorax auritus, Pelicaniformes) chicks in the North American Great Lakes
Concentrations of polychlorinated biphenyls (PCBs), and 2,3,7,8-tetrachlordibenzo-p-dioxin equivalents (TCDD-EQ) were determined in eggs and chicks of double-crested cormorants (DCC) which were collected in 1989 from eight locations in the Laurentian Great Lakes. The mean biomagnification factor (BMF) from forage fish to eggs was found to be 31.3. Absolute and relative concentrations as...
Authors
P. D. Jones, J. P. Giesy, J.L. Newsted, D. A. Verbrugge, J.P. Ludwig, M. E. Ludwig, H. J. Auman, R. Crawford, D. E. Tillitt, T.J. Kubiak, D. A. Best
Large-scale dialysis of sample lipids Large-scale dialysis of sample lipids
The use of a semipermeable membrane device (SPMD) for dialysis in an organic solvent phase is an efficient alternative approach to separation of contaminants from large amounts of lipid (up to 50 grams or more) prior to organic chemical analysis. Passive separation of contaminants can be accomplished with a minimum of equipment and a comparatively small volume of solvent. This study...
Authors
Jill Meadows, Donald E. Tillitt, James Huckins, D. Schroeder
Dioxin-like toxic potency in Forster's tern eggs from Green Bay, Lake Michigan, North America Dioxin-like toxic potency in Forster's tern eggs from Green Bay, Lake Michigan, North America
The endangered Forster's tern (Sternaforsteri) population on Green Bay, Wisconsin has exhibited symptoms of embryotoxicity, congenital deformities, and poor hatching success. The putative causal agents are planar halogenated hydrocarbons (PHH). The objectives of this study were: 1) to evaluate the toxic potency of PHHs in extracts of Forster's tern eggs taken from Green Bay, Lake...
Authors
D. E. Tillitt, T.J. Kubiak, G.T. Ankley, J. P. Giesy
Determination of mono- and non-o,o′-chlorine substituted polychlorinated biphenyls in Aroclors and environmental samples Determination of mono- and non-o,o′-chlorine substituted polychlorinated biphenyls in Aroclors and environmental samples
High resolution capillary gas chromatography (GC) is the best known technique for the separation of complex mixtures; however, no single GC column has yet separated all 209 congeners of polychlorinated biphenyls (PCBs). A number of coeluting PCB congener pairs exist, and even under favorable separation conditions such as with multidimensional GC, assignment of peak identities to known...
Authors
Ted R. Schwartz, Donald E. Tillitt, Kevin P. Feltz, Paul H. Peterman
Uptake of planar polychlorinated biphenyls and 2,3,7,8-substituted polychlorinated dibenzofurans and dibenzo-p-dioxins by birds nesting in the lower Fox River and Green Bay, Wisconsin, USA Uptake of planar polychlorinated biphenyls and 2,3,7,8-substituted polychlorinated dibenzofurans and dibenzo-p-dioxins by birds nesting in the lower Fox River and Green Bay, Wisconsin, USA
The uptake of persistent polychlorinated hydrocarbons (PCHs) by four avian species was investigated at upper trophic levels of two aquatic food chains of the lower Fox River and Green Bay, Wisconsin. Accumulation of total and specific planar polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), polychlorinated dibenzo-p-dioxin (PCDDs), and H411E rat hepatoma cell...
Authors
Gerald T. Ankley, Gerald J. Niemi, Keith B. Lodge, Hallett J. Harris, Donald L. Beaver, Donald E. Tillitt, Ted R. Schwartz, John P. Giesy, Paul D. Jones, Cynthia Hagley
Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents
In recent years contamination of the Great Lakes ecosystem with planar chlorinated hydrocarbons (PCHs) has attracted considerable concern due to their known reproductive and teratogenic effects. The H4IIE bioassay has been standardized as a means of measuring the biological potency of a PCH mixture as 2,3,7,8-tetrachloro-p-dibenzodioxin equivalents (TCDD-EQ). Using this bioassay we have
Authors
P. D. Jones, G.T. Ankley, D. A. Best, R. Crawford, N. DeGalan, J. P. Giesy, T.J. Kubiak, J. P. Ludwig, J.L. Newsted, D. E. Tillitt, D. A. Verbrugge
2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents in tissues of birds at Green Bay, Wisconsin, USA 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents in tissues of birds at Green Bay, Wisconsin, USA
The environment has become contaminated with complex mixtures of planar, chlorinated hydrocarbons (PCHs) such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and structurally similar compounds. Because the potencies of individual congeners to cause the same adverse effects vary greatly and the relative as well as...
Authors
Paul D. Jones, John P. Giesy, John L. Newsted, David A. Verbrugge, Donald L. Beaver, Gerald T. Ankley, Donald E. Tillitt, Keith B. Lodge, Gerald J. Niemi
Caspian tern reproduction in the Saginaw Bay ecosystem following a 100-year flood event Caspian tern reproduction in the Saginaw Bay ecosystem following a 100-year flood event
In the 2 years that followed the 100-year flood incident of September 1986 in the Saginaw River/Bay ecosystem, the reproduction of Caspian terns collapsed and then slowly recovered. Egg viability and fledging rates of hatched chicks were drastically depressed in 1987 and 1988. Eggs from clutches laid later in the year were less viable and chicks hatched from these eggs displayed wasting...
Authors
James P. Ludwig, Heidi J. Auman, Hiroko Kurita, Matthew E. Ludwig, Loraine M. Campbell, John P. Giesy, Donald E. Tillitt, Paul Jones, Nobu Yamashita, Shinsuke Tanabe, Ryo Tatsukawa
A comparison of water quality criteria for the Great Lakes based on human and wildlife health A comparison of water quality criteria for the Great Lakes based on human and wildlife health
Water quality criteria (WQC) can be derived in several ways. The usual techniques involve hazard and risk assessment procedures. For non-persistent, non-biomagnified compounds and elements, WQC are experimentally derived from their acute and chronic toxicity to aquatic organisms. For those persistent chlorinated hydrocarbons (PCHs) that are bioaccumulated and biomagnified, these...
Authors
James P. Ludwig, John P. Giesy, Cheryl L. Summer, William Bowerman, Richard J. Aulerich, Steven J. Bursian, Heidi J. Auman, Paul D. Jones, Lisa L. Williams, Donald E. Tillitt, Michael Gilbertson
Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the Great Lakes Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the Great Lakes
We evaluated the overall potency of polychlorinated biphenyl (PCB)-containing extracts from double-crested cormorant (Phalacrocorax auritis) eggs with an in vitro bioassay system, the H4IIE rat hepatoma cell bioassay. Results from the H4IIE bioassay were strongly correlated with the hatching success of eggs in the colonies, whereas conventional methods of PCB analysis correlated poorly...
Authors
D. E. Tillitt, G.T. Ankley, J. P. Giesy, J.P. Ludwig, H. Kurita-Matsuba, D. V. Weseloh, P.S. Ross, C.A. Bishop, L. Sileo, K. L. Stromborg, J. Larson, T.J. Kubiak
H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes
Fish-eating waterbirds from the Great Lakes of North America have shown symptoms of poisoning similar to those observed in laboratory exposures of various avian species to planar halogenated hydrocarbons (PHHs). PHHs, include among others, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) and have been implicated in...
Authors
Donald E. Tillitt, Gerald T. Ankley, David A. Verbrugge, John P. Giesy, James P. Ludwig, Timothy J. Kubiak
Science and Products
Filter Total Items: 215
Accumulation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents by double-crested cormorant (Phalacrocorax auritus, Pelicaniformes) chicks in the North American Great Lakes Accumulation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents by double-crested cormorant (Phalacrocorax auritus, Pelicaniformes) chicks in the North American Great Lakes
Concentrations of polychlorinated biphenyls (PCBs), and 2,3,7,8-tetrachlordibenzo-p-dioxin equivalents (TCDD-EQ) were determined in eggs and chicks of double-crested cormorants (DCC) which were collected in 1989 from eight locations in the Laurentian Great Lakes. The mean biomagnification factor (BMF) from forage fish to eggs was found to be 31.3. Absolute and relative concentrations as...
Authors
P. D. Jones, J. P. Giesy, J.L. Newsted, D. A. Verbrugge, J.P. Ludwig, M. E. Ludwig, H. J. Auman, R. Crawford, D. E. Tillitt, T.J. Kubiak, D. A. Best
Large-scale dialysis of sample lipids Large-scale dialysis of sample lipids
The use of a semipermeable membrane device (SPMD) for dialysis in an organic solvent phase is an efficient alternative approach to separation of contaminants from large amounts of lipid (up to 50 grams or more) prior to organic chemical analysis. Passive separation of contaminants can be accomplished with a minimum of equipment and a comparatively small volume of solvent. This study...
Authors
Jill Meadows, Donald E. Tillitt, James Huckins, D. Schroeder
Dioxin-like toxic potency in Forster's tern eggs from Green Bay, Lake Michigan, North America Dioxin-like toxic potency in Forster's tern eggs from Green Bay, Lake Michigan, North America
The endangered Forster's tern (Sternaforsteri) population on Green Bay, Wisconsin has exhibited symptoms of embryotoxicity, congenital deformities, and poor hatching success. The putative causal agents are planar halogenated hydrocarbons (PHH). The objectives of this study were: 1) to evaluate the toxic potency of PHHs in extracts of Forster's tern eggs taken from Green Bay, Lake...
Authors
D. E. Tillitt, T.J. Kubiak, G.T. Ankley, J. P. Giesy
Determination of mono- and non-o,o′-chlorine substituted polychlorinated biphenyls in Aroclors and environmental samples Determination of mono- and non-o,o′-chlorine substituted polychlorinated biphenyls in Aroclors and environmental samples
High resolution capillary gas chromatography (GC) is the best known technique for the separation of complex mixtures; however, no single GC column has yet separated all 209 congeners of polychlorinated biphenyls (PCBs). A number of coeluting PCB congener pairs exist, and even under favorable separation conditions such as with multidimensional GC, assignment of peak identities to known...
Authors
Ted R. Schwartz, Donald E. Tillitt, Kevin P. Feltz, Paul H. Peterman
Uptake of planar polychlorinated biphenyls and 2,3,7,8-substituted polychlorinated dibenzofurans and dibenzo-p-dioxins by birds nesting in the lower Fox River and Green Bay, Wisconsin, USA Uptake of planar polychlorinated biphenyls and 2,3,7,8-substituted polychlorinated dibenzofurans and dibenzo-p-dioxins by birds nesting in the lower Fox River and Green Bay, Wisconsin, USA
The uptake of persistent polychlorinated hydrocarbons (PCHs) by four avian species was investigated at upper trophic levels of two aquatic food chains of the lower Fox River and Green Bay, Wisconsin. Accumulation of total and specific planar polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs), polychlorinated dibenzo-p-dioxin (PCDDs), and H411E rat hepatoma cell...
Authors
Gerald T. Ankley, Gerald J. Niemi, Keith B. Lodge, Hallett J. Harris, Donald L. Beaver, Donald E. Tillitt, Ted R. Schwartz, John P. Giesy, Paul D. Jones, Cynthia Hagley
Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents Biomagnification of bioassay derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents
In recent years contamination of the Great Lakes ecosystem with planar chlorinated hydrocarbons (PCHs) has attracted considerable concern due to their known reproductive and teratogenic effects. The H4IIE bioassay has been standardized as a means of measuring the biological potency of a PCH mixture as 2,3,7,8-tetrachloro-p-dibenzodioxin equivalents (TCDD-EQ). Using this bioassay we have
Authors
P. D. Jones, G.T. Ankley, D. A. Best, R. Crawford, N. DeGalan, J. P. Giesy, T.J. Kubiak, J. P. Ludwig, J.L. Newsted, D. E. Tillitt, D. A. Verbrugge
2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents in tissues of birds at Green Bay, Wisconsin, USA 2,3,7,8-Tetrachlorodibenzo-p-dioxin equivalents in tissues of birds at Green Bay, Wisconsin, USA
The environment has become contaminated with complex mixtures of planar, chlorinated hydrocarbons (PCHs) such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and structurally similar compounds. Because the potencies of individual congeners to cause the same adverse effects vary greatly and the relative as well as...
Authors
Paul D. Jones, John P. Giesy, John L. Newsted, David A. Verbrugge, Donald L. Beaver, Gerald T. Ankley, Donald E. Tillitt, Keith B. Lodge, Gerald J. Niemi
Caspian tern reproduction in the Saginaw Bay ecosystem following a 100-year flood event Caspian tern reproduction in the Saginaw Bay ecosystem following a 100-year flood event
In the 2 years that followed the 100-year flood incident of September 1986 in the Saginaw River/Bay ecosystem, the reproduction of Caspian terns collapsed and then slowly recovered. Egg viability and fledging rates of hatched chicks were drastically depressed in 1987 and 1988. Eggs from clutches laid later in the year were less viable and chicks hatched from these eggs displayed wasting...
Authors
James P. Ludwig, Heidi J. Auman, Hiroko Kurita, Matthew E. Ludwig, Loraine M. Campbell, John P. Giesy, Donald E. Tillitt, Paul Jones, Nobu Yamashita, Shinsuke Tanabe, Ryo Tatsukawa
A comparison of water quality criteria for the Great Lakes based on human and wildlife health A comparison of water quality criteria for the Great Lakes based on human and wildlife health
Water quality criteria (WQC) can be derived in several ways. The usual techniques involve hazard and risk assessment procedures. For non-persistent, non-biomagnified compounds and elements, WQC are experimentally derived from their acute and chronic toxicity to aquatic organisms. For those persistent chlorinated hydrocarbons (PCHs) that are bioaccumulated and biomagnified, these...
Authors
James P. Ludwig, John P. Giesy, Cheryl L. Summer, William Bowerman, Richard J. Aulerich, Steven J. Bursian, Heidi J. Auman, Paul D. Jones, Lisa L. Williams, Donald E. Tillitt, Michael Gilbertson
Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the Great Lakes Polychlorinated biphenyl residues and egg mortality in double-crested cormorants from the Great Lakes
We evaluated the overall potency of polychlorinated biphenyl (PCB)-containing extracts from double-crested cormorant (Phalacrocorax auritis) eggs with an in vitro bioassay system, the H4IIE rat hepatoma cell bioassay. Results from the H4IIE bioassay were strongly correlated with the hatching success of eggs in the colonies, whereas conventional methods of PCB analysis correlated poorly...
Authors
D. E. Tillitt, G.T. Ankley, J. P. Giesy, J.P. Ludwig, H. Kurita-Matsuba, D. V. Weseloh, P.S. Ross, C.A. Bishop, L. Sileo, K. L. Stromborg, J. Larson, T.J. Kubiak
H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes H4IIE rat hepatoma cell bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in colonial fish-eating waterbird eggs from the Great Lakes
Fish-eating waterbirds from the Great Lakes of North America have shown symptoms of poisoning similar to those observed in laboratory exposures of various avian species to planar halogenated hydrocarbons (PHHs). PHHs, include among others, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) and have been implicated in...
Authors
Donald E. Tillitt, Gerald T. Ankley, David A. Verbrugge, John P. Giesy, James P. Ludwig, Timothy J. Kubiak
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