Hon Ip
Biography
As a Diagnostic and Research Virologist, I am interested in the emergence and spread of novel, introduced, and endemic viral diseases of wildlife. For example, through the National Wildlife Health Center’s long-standing program to investigate wildlife mortality events in the United States, our Diagnostic Virology Laboratory was first to detect introductions of West Nile Virus (in 1999) and Highly Pathogenic Avian Influenza H5N8 (in 2014). Both of these introductions resulted in large-scale monitoring efforts that provided real-time and actionable intelligence to state and federal partners for disease response. We have also investigated periodic recurrence of Newcastle Disease in cormorants, geographic expansion of Eurasian collared doves and associated spread of pigeon paramyxovirus, and applied phylogenetic approaches to understand the diversity and transmission of viral diseases on the landscape. Since 2008 we have been studying viruses in North American bats, including coronaviruses. Following the recent emergence of COVID-19, this work provides a highly relevant framework for investigating possible impacts of the SARS-CoV-2 virus on native, North American bat species, and for more broadly characterizing the diversity of coronaviruses in North American wildlife.
Education
- Ph. D. Molecular Parasitology. The Rockefeller University, New York, NY.
- M. Sc. Microbiology and Parasitology. University of Toronto, Ontario, Canada.
- B. Sc. Microbiology and Parasitology. University of Toronto, Ontario, Canada.
Affiliations
- Honorary Associate Fellow. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison.
- Adjunct Assistant Professor. Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison.
Science and Products
Presence of avian influenza viruses in waterfowl and wetlands during summer 2010 in California: Are resident birds a potential reservoir?
Although wild waterfowl are the main reservoir for low pathogenic avian influenza viruses (LPAIv), the environment plays a critical role for the circulation and persistence of AIv. LPAIv may persist for extended periods in cold environments, suggesting that waterfowl breeding areas in the northern hemisphere may be an important reservoir for AIv...
Henaux, V.; Samuel, M.D.; Dusek, Robert J.; Fleskes, J.P.; Ip, Hon S. Experimental challenge and pathology of highly pathogenic avian influenza virus H5N1 in dunlin (Calidris alpina), an intercontinental migrant shorebird species
Background Shorebirds (Charadriiformes) are considered one of the primary reservoirs of avian influenza. Because these species are highly migratory, there is concern that infected shorebirds may be a mechanism by which highly pathogenic avian influenza virus (HPAIV) H5N1 could be introduced into North America from Asia. Large numbers of dunlin (...
Hall, Jeffrey S.; Franson, J. Christian; Gill, Robert E.; Meteyer, Carol U.; TeSlaa, Joshua L.; Nashold, Sean W.; Dusek, Robert J.; Ip, Hon S. Influence of body condition on influenza A virus infection in mallard ducks: Experimental infection data
Migrating waterfowl are implicated in the global spread of influenza A viruses (IAVs), and mallards (Anas platyrhynchos) are considered a particularly important IAV reservoir. Prevalence of IAV infection in waterfowl peaks during autumn pre-migration staging and then declines as birds reach wintering areas. Migration is energetically costly and...
Arsnoe, Dustin M.; Ip, Hon S.; Owen, Jennifer C. Evidence for limited exchange of avian influenza viruses between seaducks and dabbling ducks at Alaska Peninsula coastal lagoons
Avian influenza virus (AIV) prevalence and sequence data were analyzed for Steller's eiders (Polysticta stelleri) to assess the role of this species in transporting virus genes between continents and maintaining a regional viral reservoir with sympatric northern pintails (Anas acuta). AIV prevalence was 0.2% at Izembek Lagoon and 3.9% at Nelson...
Ramey, Andrew M.; Pearce, John M.; Reeves, Andrew B.; Franson, J. Christian; Petersen, Margaret R.; Ip, Hon S. Interspecific exchange of avian influenza virus genes in Alaska: The influence of trans-hemispheric migratory tendency and breeding ground sympatry
The movement and transmission of avian influenza viral strains via wild migratory birds may vary by host species as a result of migratory tendency and sympatry with other infected individuals. To examine the roles of host migratory tendency and species sympatry on the movement of Eurasian low-pathogenic avian influenza (LPAI) genes into North...
Pearce, John M.; Reeves, Andrew B.; Ramey, Andrew M.; Hupp, Jerry W.; Ip, Hon S.; Bertram, M.; Petrula, M.J.; Scotton, B.D.; Trust, K.A.; Meixell, Brandt W.; Runstadler, J.A. Evaluation of Nobuto filter paper strips for the detection of avian influenza virus antibody in waterfowl
The utility of using Nobuto paper strips for the detection of avian influenza antibodies was examined in mallards (Anas platyrhynchos) experimentally infected with low pathogenic avian influenza viruses. Blood was collected 2 wk after infection and was preserved either as serum or whole blood absorbed onto Nobuto strips. Analysis of samples using...
Dusek, Robert J.; Hall, Jeffrey S.; Nashold, Sean W.; Teslaa, Joshua L.; Ip, Hon S. Influence of body condition on influenza a virus infection in mallard ducks: Experimental infection data
Migrating waterfowl are implicated in the global spread of influenza A viruses (IAVs), and mallards (Anas platyrhynchos) are considered a particularly important IAV reservoir. Prevalence of IAV infection in waterfowl peaks during autumn pre-migration staging and then declines as birds reach wintering areas. Migration is energetically costly and...
Arsnoe, D.M.; Ip, Hon S.; Owen, J.C. Intercontinental reassortment and genomic variation of low pathogenic avian influenza viruses isolated from northern pintails (Anas acuta) in Alaska: examining the evidence through space and time
Migration and population genetic data for northern pintails (Anas acuta) and phylogenetic analysis of low pathogenic avian influenza (LPAI) viruses from this host in Alaska suggest that northern pintails are involved in ongoing intercontinental transmission of avian influenza. Here, we further refine this conclusion through phylogenetic analyses...
Ramey, Andrew M.; Pearce, John M.; Flint, Paul L.; Ip, Hon S.; Derksen, Dirk V.; Franson, J. Christian; Petrula, Michael J.; Scotton, Bradley D.; Sowl, Kristine M.; Wege, Michael L.; Trust, Kimberly A. Limited evidence of trans-hemispheric movement of avian influenza viruses among contemporary North American shorebird isolates
Migratory routes of gulls, terns, and shorebirds (Charadriiformes) are known to cross hemispheric boundaries and intersect with outbreak areas of highly pathogenic avian influenza (HPAI). Prior assessments of low pathogenic avian influenza (LPAI) among species of this taxonomic order found some evidence for trans-hemispheric movement of virus...
Pearce, John M.; Ramey, Andrew M.; Ip, Hon S.; Gill, Robert E. Transmission and reassortment of avian influenza viruses at the Asian-North American interface
Twenty avian influenza viruses were isolated from seven wild migratory bird species sampled at St. Lawrence Island, Alaska. We tested predictions based on previous phylogenetic analyses of avian influenza viruses that support spatially dependent trans-hemispheric gene flow and frequent interspecies transmission at a location situated at the Asian...
Ramey, Andrew M.; Pearce, John M.; Ely, Craig R.; Guy, Lisa M. Sheffield; Irons, David B.; Derksen, Dirk V.; Ip, Hon S. Validation of a real-time reverse transcriptase-PCR assay for the detection of H7 avian influenza virus
This report describes the validation of an avian influenza virus (AIV) H7 subtype-specific real-time reverse transcriptasePCR (rRT-PCR) assay developed at the Southeast Poultry Research Laboratory (SEPRL) for the detection of H7 AI in North and South American wild aquatic birds and poultry. The validation was a collaborative effort by the SEPRL...
Pedersen, J.; Killian, M.L.; Hines, N.; Senne, D.; Panigrahy, B.; Ip, Hon S.; Spackman, Erica Avian influenza at both ends of a migratory flyway: characterizing viral genomic diversity to optimize surveillance plans for North America
Although continental populations of avian influenza viruses are genetically distinct, transcontinental reassortment in low pathogenic avian influenza (LPAI) viruses has been detected in migratory birds. Thus, genomic analyses of LPAI viruses could serve as an approach to prioritize species and regions targeted by North American surveillance...
Pearce, John M.; Ramey, Andrew M.; Flint, Paul L.; Koehler, Anson V.; Fleskes, Joseph P.; Franson, J. Christian; Hall, Jeffrey S.; Derksen, Dirk V.; Ip, Hon S.