Jason T. Magnuson, PhD (Former Employee)
Science and Products
Healthy Fish and Wildlife: Community Livelihoods, Fishing and Hunting Heritage, Recreation, and Economic Security
Healthy fish and wildlife underpin the economic vitality, food security, recreational enjoyment, and cultural heritage of fishing and hunting in communities across the United States. Fishing and hunting resources scale from the personal recreation of families to multi-billion-dollar industries. Recognizing these critical connections, the U.S. Geological Survey (USGS) works to understand, protect...
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Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Toxic Substances Hydrology, California Water Science Center, Central Midwest Water Science Center, Columbia Environmental Research Center, Eastern Ecological Science Center, Forest and Rangeland Ecosystem Science Center, Upper Midwest Environmental Sciences Center, Upper Midwest Water Science Center
Perfluorohexanesulfonic Acid (PFHxS) Dysregulates Lipid Homeostasis in Early Life Stage Fish
A frequently detected perfluorinated compound in the environment, perfluorohexanesulfonic acid (PFHxS), can alter lipid metabolism in developing fish. This work identifies a novel mechanism in which PFHxS targets lipid metabolism pathways by using multiple omic techniques and modeling approaches.
Gut-Liver Axis: Review on How Microplastics Can Cause Toxicity Through an Interaction Between the Gut, Microbial Community, and Liver
Microplastics can cause liver damage when consumed by terrestrial and aquatic organisms. This review proposes a novel mechanism to help explain the toxic effects following ingestion, which involves the gut, microbial community, and liver through the gut-liver axis.
Study Finds PFOSA Can Suppress Immune Function in Developing Zebrafish (Danio rerio)
The Stockholm Convention has labeled PFOS a “persistent organic pollutant” due to its long-enduring prevalence, negative toxicological effects, and ability to bioaccumulate in living things. Concerns about PFOSA have been raised due to its similarity to PFOS, its ability to metabolize into PFOS, and its persistent use today
Comprehensive Research on PFAS Exposomics and Risk Assessment
The Columbia Environmental Research Center (CERC) conducts cutting-edge research on per- and polyfluoroalkyl substances (PFAS) through the lens of the One Health Paradigm, emphasizing the interconnectedness of human, animal, and environmental health.
Fishing, Hunting and Subsistence Living Integrated Science Team
The Fishing, Hunting, and Subsistence Living Integrated Science Team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively...
Toxic effects of carbamazepine to embryonically exposed zebrafish during early life stage development Toxic effects of carbamazepine to embryonically exposed zebrafish during early life stage development
Embryonic zebrafish (Danio rerio) were exposed to 0, 1, 5, 10, or 50 micrograms per liter carbamazepine (CBZ) from 2 hours post fertilization (hpf) through hatching, and then sampled at 48, 72, or 144 hpf. Larvae collected at 48, 72, and 144 hpf were assessed for transcriptomic profiles using RNA sequencing. Larvae collected at 72 and 144 hpf time points were assessed for histological...
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Effects of carbamazepine to visual function in early life stage fish Effects of carbamazepine to visual function in early life stage fish
The frequent detection of pharmaceuticals and personal care products (PPCPs) in the environment raises concern for aquatic systems. Carbamazepine (CBZ), an antiepileptic drug, is among the most detected PPCP globally, with concentrations in surface water exceeding those that induce toxicity to aquatic organisms. Non-targeted transcriptomic profiling was conducted in zebrafish (Danio...
Authors
Jason Tyler Magnuson, Holly J. Puglis, Jessica K. Leet, Adam H. Moody, Célio Freire Mariz, Thea M. Edwards, Daniela M. Pampanin
Amitriptyline and nortriptyline induce ocular toxicity in early life stage zebrafish (Danio rerio) Amitriptyline and nortriptyline induce ocular toxicity in early life stage zebrafish (Danio rerio)
The global use of antidepressants has steadily increased, raising concern to aquatic ecosystems due to the incomplete removal during wastewater treatment. Tricyclic antidepressants (TCAs) act on the neuronal system by inhibiting the reuptake of serotonin and norepinephrine. However, despite visual function being heavily dependent on the neuronal system, a knowledge gap remains regarding...
Authors
Marwin Jafari, Jason Tyler Magnuson, Fabian Essfeld, Sebastian Eilebrecht, Katharina Brotzmann, Daniela M. Pampanin
Perfluorodecanoic acid (PFDA) disrupts immune regulation via the toll-like receptor signaling pathway in zebrafish Perfluorodecanoic acid (PFDA) disrupts immune regulation via the toll-like receptor signaling pathway in zebrafish
As there are a growing number of per- and polyfluoroalkyl substances (PFAS) alternative substitutes applied globally, it remains paramount to characterize their potential health risks. Perfluorodecanoic acid (PFDA) is the most common alternative PFAS detected in the environment; however, its toxic effects and underlying mechanism of action to aquatic biota remains unclear. In this study...
Authors
Jiazhen Wang, Di Fang, Jason Tyler Magnuson, Bentuo Xu, Chunmiao Zheng, Liang Tang, Wenhui Qiu
Metabolomic profiling identifies the mitochondria as a target of pentachlorophenol toxicity in the blood clam (Tegillarca granosa) Metabolomic profiling identifies the mitochondria as a target of pentachlorophenol toxicity in the blood clam (Tegillarca granosa)
The pervasive presence of pentachlorophenol (PCP) in aquatic-benthic ecosystems poses a threat to organisms. However, the toxicological mechanisms of PCP in benthic organisms are limited. In this study, Tegillarca granosa, a representative bivalve species, was treated with environmentally relevant concentrations of PCP (1, 10, and 100 μg/kg) and positive control for 28 days via sediment...
Authors
Yuyao Jiang, Yujia Yan, Yanru Guan, Jason Tyler Magnuson, Zijie Ding, Qingqing Ke, Aoxue Wang, Kun Qiao, Shuying Li, Wenjun Gui, Daniel Schlenk
Ecotoxicological effects of crude oil to early life stage Danio rerio: A molecular, morphological and behavioral approach focused on swim bladder development Ecotoxicological effects of crude oil to early life stage Danio rerio: A molecular, morphological and behavioral approach focused on swim bladder development
Proper development and inflation of the swim bladder is essential for swimming and foraging behavior in fish. To characterize the effects of the Brazilian oil spill that occurred between 2019 and 2020 to early life stage fish, the expression of genes involved in swim bladder development were targeted, with biochemical assays, morphology, and behavior assessed. The swim bladder was...
Authors
Célio F. Mariz, Maria Karolaine de Melo Alves, Jason Tyler Magnuson, Italo Braga de Castro, Felix Augusto Silva de Andrade, Eliete Zanardi-Lamardo, Igor Dias Medeiros, Paulo S. Carvalho
Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish
Perfluorodecanesulfonate (PFDS), a long-chain polyfluoroalkyl substance (PFAS), is widely detected in aquatic environments and increasingly recognized for its environmental persistence and bioaccumulative potential; however, its immunotoxicity remains poorly understood in aquatic biota. In this study, early life stage zebrafish (Danio rerio) were exposed to environmentally relevant...
Authors
Chengwei Zhou, Wei Cheng, Rongrong Xuan, Xinyuan Kang, Jiazhen Wang, Jason Tyler Magnuson, Jialin Li, Di Fang, Wenhui Qiu
Non-USGS Publications**
Tang, L., Qiu, W., Zhang, S., Wang, J., Yang, X., Xu, B., Magnuson, J.T., Xu, E.G., Wu, M., and Zheng, C., 2023, Poly- and perfluoroalkyl substances induce immunotoxicity via the TLR pathway in zebrafish: Links to carbon-chain length: Environmental Science & Technology, v. 57, no. 15, p. 6139-6149. https://doi.org/10.1021/acs.est.2c09716
Magnuson, J.T., and Sandheinrich, M.B., 2023, Relation among mercury, selenium, and
biomarkers of oxidative stress in northern pike (Esox lucius): Toxics, v. 11, no. 3, p. 244.
https://www.mdpi.com/2305-6304/11/3/244
biomarkers of oxidative stress in northern pike (Esox lucius): Toxics, v. 11, no. 3, p. 244.
https://www.mdpi.com/2305-6304/11/3/244
Pampanin, D.M., Arnli, W.B., Magnuson, J.T., Monticelli, G., Dam, M., Mikalsen, S.-O., and Sydnes, M.O., 2023, Study of the long-finned pilot whale (Globicephala melas) bile content - An indicator of ocean health: Marine Pollution Bulletin, v. 189, p. 114795. https://doi.org/10.1016/j.marpolbul.2023.114795
Zhang, S., Zheng, M., Yang, G., Zhang, T., Magnuson, J.T., Chen, H., Zheng, C., and Qiu, W., 2023, Sunlight-mediated CaO2 inactivation of pathogen indicator organisms in surface water system: Roles of reactive species, characterization of pathogen inactivation: Water Research, v. 233, p. 119756. https://doi.org/10.1016/j.watres.2023.119756
Liu, S., Qiu, W., Li, R., Chen, B., Wu, X., Magnuson, J.T., Xu, B., Luo, S., Xu, E.G., and Zheng, C., 2023, Perfluorononanoic acid induces neurotoxicity via synaptogenesis signaling in zebrafish, v. 57, no. 9, p. 3783-3793. https://doi.org/10.1021/acs.est.2c06739
Magnuson, J.T., Fuller, N., McGruer, V., Huff Hartz, K.E., Acuña, S., Whitledge, G.W., Lydy, M.J., and Schlenk, D., 2023, Effect of temperature and dietary pesticide exposure on neuroendocrine and olfactory responses in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Pollution, v. 318, p. 120938. https://doi.org/10.1016/j.envpol.2022.120938
Chen, Q., Gao, Z., Wang, K., Magnuson, J.T., Chen, Y., Li, M., Shi, H., and Xu, L., 2023, High accumulation of microplastic fibers in fish hindgut induces an enhancement of triphenyl phosphate hydroxylation: Environmental Pollution, v. 317, p. 120804. https://doi.org/10.1016/j.envpol.2022.120804
Magnuson, J.T., Leads, R.R., McGruer, V., Qian, L., Tanabe, P., Roberts, A.P., and Schlenk, D., 2023, Transcriptomic profiling of miR-203a inhibitor and miR-34b-injected zebrafish (Danio rerio) validates oil-induced neurological, cardiovascular and eye toxicity response pathways: Aquatic Toxicology, v. 254, p. 106356. https://doi.org/10.1016/j.aquatox.2022.106356
Liu, X., Liu, S., Qiu, W., Magnuson, J.T., Liu, Z., Yang, G., Chen, H., Li, Y., Xu, X., and Zheng, C., 2022, Cardiotoxicity of PFOA, PFOS, and PFOSA in early life stage zebrafish: Molecular changes to behavioral-level response: Sustainable Horizons, v. 3, p. 100027. https://doi.org/10.1016/j.horiz.2022.100027
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., McGruer, V., Schlenk, D., and Lydy, M.J., 2022, Dietary exposure to environmentally relevant pesticide mixtures impairs swimming performance and lipid homeostatic gene expression in Juvenile Chinook salmon at elevated water temperatures: Environmental Pollution, v. 314, p. 120308. https://doi.org/10.1016/j.envpol.2022.120308
Magnuson, J.T., Longenecker-Wright, Z., Havranek, I., Monticelli, G., Brekken, H.K., Kallenborn, R., Schlenk, D., Sydnes, M.O., and Pampanin, D.M., 2022, Bioaccumulation potential of the tricyclic antidepressant amitriptyline in a marine Polychaete, Nereis virens: Science of The Total Environment, v. 851, p. 158193. https://doi.org/10.1016/j.scitotenv.2022.158193
Xuan, R., Qiu, W., Zhou, Y., Magnuson, J.T., Luo, S., Greer, J.B., Xu, B., Liu, J., Xu, E.G., Schlenk, D., and Zheng, C., 2022, Parental transfer of an antibiotic mixture induces cardiotoxicity in early life-stage zebrafish: A cross-generational study: Science of The Total Environment, v. 849, p. 157726. https://doi.org/10.1016/j.scitotenv.2022.157726
Magnuson, J.T., Caceres, L., Sy, N., Ji, C., Tanabe, P., Gan, J., Lydy, M.J., and Schlenk, D., 2022, The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss): Environmental Science & Technology, v. 56, no. 16, p. 11482-11492. https://doi.org/10.1021/acs.est.2c01542
Chen, H., Qiu, W., Yang, X., Chen, F., Chen, J., Tang, L., Zhong, H., Magnuson, J.T., Zheng, C., and Xu, E.G., 2022, Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8438-8448. https://doi.org/10.1021/acs.est.1c08875
Qiu, W., Liu, T., Liu, X., Chen, H., Luo, S., Chen, Q., Magnuson, J.T., Zheng, C., Xu, E.G., and Schlenk, D., 2022, Enrofloxacin Induces Intestinal Microbiota-Mediated Immunosuppression in Zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8428-8437. https://doi.org/10.1021/acs.est.1c08712
Leads, R.R., Magnuson, J.T., Lucero, J., Lund, A.K., Schlenk, D., Chavez, J.R., and Roberts, A.P., 2022, Transcriptomic responses and apoptosis in larval red drum (Sciaenops ocellatus) co-exposed to crude oil and ultraviolet (UV) radiation: Marine Pollution Bulletin, v. 179, p. 113684. https://doi.org/10.1016/j.marpolbul.2022.113684
Magnuson, J.T., Fuller, N., Huff Hartz, K.E., Anzalone, S., Whitledge, G.W., Acuña, S., Lydy, M.J., and Schlenk, D., 2022, Dietary exposure to bifenthrin and fipronil impacts swimming performance in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Science & Technology, v. 56, no. 8, p. 5071-5080. https://doi.org/10.1021/acs.est.1c06609
Xu, B., Qiu, W., Du, J., Wan, Z., Zhou, J.L., Chen, H., Liu, R., Magnuson, J.T., and Zheng, C., 2022, Translocation, bioaccumulation, and distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in plants: iScience, v. 25, no. 4, p. 104061. https://doi.org/10.1016/j.isci.2022.104061
Fuller, N., Anzalone, S.E., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., Magnuson, J.T., Schlenk, D., and Lydy, M.J., 2022, Bioavailability of legacy and current-use pesticides in juvenile Chinook salmon habitat of the Sacramento River watershed: Importance of sediment characteristics and extraction techniques: Chemosphere, v. 298, p. 134174. https://doi.org/10.1016/j.chemosphere.2022.134174
Anzalone, S.E., Fuller, N.W., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Magnuson, J.T., Schlenk, D., Acuña, S., and Lydy, M.J., 2022, Pesticide residues in juvenile Chinook salmon and prey items of the Sacramento River watershed, California – A comparison of riverine and floodplain habitats: Environmental Pollution, v. 303, p. 119102.
https://doi.org/10.1016/j.envpol.2022.119102
https://doi.org/10.1016/j.envpol.2022.119102
Qiu, W., Chen, B., Tang, L., Zheng, C., Xu, B., Liu, Z., Magnuson, J.T., Zhang, S., Schlenk, D., Xu, E.G., and Xing, B., 2022, Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB: Environmental Science & Technology, v. 56, no. 7, p. 4251-4261. https://doi.org/10.1021/acs.est.1c07343
Magnuson, J.T., Qian, L., McGruer, V., Cheng, V., Volz, D.C., and Schlenk, D., 2022, Relationship between miR-203a inhibition and oil-induced toxicity in early life stage zebrafish (Danio rerio): Toxicology Reports, v. 9, p. 373-381. https://doi.org/10.1016/j.toxrep.2022.03.006
Qiu, W., Chen, H., Zhang, S., Xiong, Y., Zheng, M., Zhu, T., Park, M., Magnuson, J.T., Zheng, C., and El-Din, M.G., 2022, Remediation of surface water contaminated by pathogenic microorganisms using calcium peroxide: Matrix effect, micro-mechanisms and morphological-physiological changes: Water Research, v. 211, p. 118074. https://doi.org/10.1016/j.watres.2022.118074
McGruer, V., Khursigara, A.J., Magnuson, J.T., Esbaugh, A.J., Greer, J.B., and Schlenk, D., 2021, Exposure to Deepwater Horizon crude oil increases free cholesterol in larval red drum (Sciaenops ocellatus): Aquatic Toxicology, v. 241, p. 105988. https://doi.org/10.1016/j.aquatox.2021.105988
Fuller, N., Huff Hartz, K.E., Johanif, N., Magnuson, J.T., Robinson, E.K., Fulton, C.A., Poynton, H.C., Connon, R.E., and Lydy, M.J., 2021, Enhanced trophic transfer of chlorpyrifos from resistant Hyalella azteca to inland silversides (Menidia beryllina) and effects on acetylcholinesterase activity and swimming performance at varying temperatures: Environmental Pollution, v. 291, p. 118217. https://doi.org/10.1016/j.envpol.2021.118217
Greer, J.B., Magnuson, J.T., McGruer, V., Qian, L., Dasgupta, S., Volz, D.C., and Schlenk, D., 2021, miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish (Danio rerio) Embryos: Chemical Research in Toxicology, v. 34, no. 10, p. 2209-2215. https://doi.org/10.1021/acs.chemrestox.1c00238
Ajitha, V., Sarasan, M., Parvathi Sreevidya, C., Aswathy, C., Kachiprath, B., Mohandas, A., Singh, I.S.B., Hameed, A.S.S., Schlenk, D., Magnuson, J.T., and Puthumana, J., 2021, Cytotoxic impacts of treated electroplating industrial effluent and the comparative effect of their metal components (Zn, Hg, and Zn+Hg) on Danio rerio gill (DrG) cell line: Science of The Total Environment, v. 793, p. 148533. https://doi.org/10.1016/j.scitotenv.2021.148533
Ji, C., Tanabe, P., Shi, Q., Qian, L., McGruer, V., Magnuson, J.T., Wang, X., Gan, J., Gadepalli, R.S., Rimoldi, J., and Schlenk, D., 2021, Stage Dependent Enantioselective Metabolism of Bifenthrin in Embryos of Zebrafish (Danio rerio) and Japanese Medaka (Oryzias latipes): Environmental Science & Technology, v. 55, no. 13, p. 9087-9096. https://doi.org/10.1021/acs.est.1c01663
Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Lydy, M.J., and Schlenk, D., 2021, Transcriptomic and Histopathological Effects of Bifenthrin to the Brain of Juvenile Rainbow Trout (Oncorhynchus mykiss): Toxics, v. 9, no. 3, p. 48. https://doi.org/10.3390/toxics9030048
Harraka, G.T., Magnuson, J.T., Du, B., Wong, C.S., Maruya, K., and Schlenk, D., 2021, Evaluating the estrogenicity of an effluent-dominated river in California, USA: Comparisons of in vitro and in vivo bioassays: Science of The Total Environment, v. 758, p. 143965. https://doi.org/10.1016/j.scitotenv.2020.143965
Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., and Wang, C., 2021, Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems: Journal of Hazardous Materials, v. 404, p. 124083. https://doi.org/10.1016/j.jhazmat.2020.124083
Ji, C., Magnuson, J.T., Zhang, W., and Zhao, M., 2021, New insight into the enantioselective cytotoxicity of cypermethrin: imbalance between cell cycle and apoptosis: Journal of Hazardous Materials, v. 403, p. 123893. https://doi.org/10.1016/j.jhazmat.2020.123893
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Acuña, S., Schlenk, D., and Lydy, M.J., 2021, Effects of dietary cypermethrin exposure on swimming performance and expression of lipid homeostatic genes in livers of juvenile Chinook salmon, Oncorhynchus tshawytscha: Ecotoxicology, v. 30, no. 2, p. 257-267. https://doi.org/10.1007/s10646-021-02352-2
Chen, Q., Santos, M.M.d., Tanabe, P., Harraka, G.T., Magnuson, J.T., McGruer, V., Qiu, W., Shi, H., Snyder, S.A., and Schlenk, D., 2021, Bioassay guided analysis coupled with non-target chemical screening in polyethylene plastic shopping bag fragments after exposure to simulated gastric juice of Fish: Journal of Hazardous Materials, v. 401, p. 123421. https://doi.org/10.1016/j.jhazmat.2020.123421
Magnuson, J.T., Cryder, Z., Andrzejczyk, N.E., Harraka, G., Wolf, D.C., Gan, J., and Schlenk, D., 2020, Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment: Environmental Science & Technology, v. 54, no. 19, p. 12245-12253. https://doi.org/10.1021/acs.est.0c04847
Magnuson, J.T., Stieglitz, J.D., Garza, S.A., Benetti, D.D., Grosell, M., and Roberts, A.P., 2020, Development of visual function in early life stage mahi-mahi (coryphaena hippurus): Marine and Freshwater Behaviour and Physiology, v. 53, no. 5-6, p. 203-214. https://doi.org/10.1080/10236244.2020.1804300
Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., and Schlenk, D., 2020, Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring: Journal of Hazardous Materials, v. 399, p. 123009. https://doi.org/10.1016/j.jhazmat.2020.123009
Magnuson, J.T., Giroux, M., Cryder, Z., Gan, J., and Schlenk, D., 2020, The use of non-targeted metabolomics to assess the toxicity of bifenthrin to juvenile Chinook salmon (Oncorhynchus tshawytscha): Aquatic Toxicology, v. 224, p. 105518. https://doi.org/10.1016/j.aquatox.2020.105518
Bridges, K.N., Magnuson, J.T., Curran, T.E., Barker, A., Roberts, A.P., and Venables, B.J., 2019, Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure: Environmental Toxicology and Pharmacology, v. 69, p. 137-142. https://doi.org/10.1016/j.etap.2019.04.011
Perrichon, P., Stieglitz, J.D., Xu, E.G., Magnuson, J.T., Pasparakis, C., Mager, E.M., Wang, Y., Schlenk, D., Benetti, D.D., Roberts, A.P., Grosell, M., and Burggren, W.W., 2019, Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes: Developmental Dynamics, v. 248, no. 5, p. 337-350. https://doi.org/10.1002/dvdy.27
Xu, E.G., Magnuson, J.T., Diamante, G., Mager, E., Pasparakis, C., Grosell, M., Roberts, A.P., and Schlenk, D., 2018, Changes in microRNA–mRNA Signatures Agree with Morphological, Physiological, and Behavioral Changes in Larval Mahi-Mahi Treated with Deepwater Horizon Oil: Environmental Science & Technology, v. 52, no. 22, p. 13501-13510. https://doi.org/10.1021/acs.est.8b04169
Magnuson, J.T., Khursigara, A.J., Allmon, E.B., Esbaugh, A.J., and Roberts, A.P., 2018, Effects of Deepwater Horizon crude oil on ocular development in two estuarine fish species, red drum (Sciaenops ocellatus) and sheepshead minnow (Cyprinodon variegatus): Ecotoxicology and Environmental Safety, v. 166, p. 186-191. https://doi.org/10.1016/j.ecoenv.2018.09.087
Nielsen, K.M., Zhang, Y., Curran, T.E., Magnuson, J.T., Venables, B.J., Durrer, K.E., Allen, M.S., and Roberts, A.P., 2018, Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury: Environmental Science & Technology, v. 52, no. 15, p. 8774-8784. https://doi.org/10.1021/acs.est.8b01150
Nielsen, K.M., Krasnec, M.O., Magnuson, J.T., Morris, J.M., Gielazyn, M.L., Chavez, J.R., and Roberts, A.P., 2018, Influence of variable ultraviolet radiation and oil exposure duration on survival of red drum (Sciaenops ocellatus) larvae: Environmental Toxicology and Chemistry, v. 37, no. 9, p. 2372-2379. https://doi.org/10.1002/etc.4183
Xu, E.G., Khursigara, A.J., Magnuson, J., Hazard, E.S., Hardiman, G., Esbaugh, A.J., Roberts, A.P., and Schlenk, D., 2017, Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure to Weathered Deepwater Horizon Crude Oil: Developmental and Transcriptomic Consequences: Environmental Science & Technology, v. 51, no. 17, p. 10162-10172. https://doi.org/10.1021/acs.est.7b02037
Sweet, L.E., Magnuson, J., Garner, T.R., Alloy, M.M., Stieglitz, J.D., Benetti, D., Grosell, M., and Roberts, A.P., 2017, Exposure to ultraviolet radiation late in development increases the toxicity of oil to mahi-mahi (Coryphaena hippurus) embryos: Environmental Toxicology and Chemistry, v. 36, no. 6, p. 1592-1598. https://doi.org/10.1002/etc.3687
Magnuson, J.T., and Schlenk, D., 2023, Chapter 3.2.1 - Metabolism vs. metabolomics: Mechanisms of endocrine disruption, in Carnevali, O., and Hardiman, G., eds., Environmental Contaminants and Endocrine Health: Academic Press, p. 235-245.
https://doi.org/10.1016/B978-0-12-824464-7.00014-3
https://doi.org/10.1016/B978-0-12-824464-7.00014-3
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.
Science and Products
Healthy Fish and Wildlife: Community Livelihoods, Fishing and Hunting Heritage, Recreation, and Economic Security
Healthy fish and wildlife underpin the economic vitality, food security, recreational enjoyment, and cultural heritage of fishing and hunting in communities across the United States. Fishing and hunting resources scale from the personal recreation of families to multi-billion-dollar industries. Recognizing these critical connections, the U.S. Geological Survey (USGS) works to understand, protect...
By
Ecosystems Mission Area, Contaminant Biology, Environmental Health Program, Toxic Substances Hydrology, California Water Science Center, Central Midwest Water Science Center, Columbia Environmental Research Center, Eastern Ecological Science Center, Forest and Rangeland Ecosystem Science Center, Upper Midwest Environmental Sciences Center, Upper Midwest Water Science Center
Perfluorohexanesulfonic Acid (PFHxS) Dysregulates Lipid Homeostasis in Early Life Stage Fish
A frequently detected perfluorinated compound in the environment, perfluorohexanesulfonic acid (PFHxS), can alter lipid metabolism in developing fish. This work identifies a novel mechanism in which PFHxS targets lipid metabolism pathways by using multiple omic techniques and modeling approaches.
Gut-Liver Axis: Review on How Microplastics Can Cause Toxicity Through an Interaction Between the Gut, Microbial Community, and Liver
Microplastics can cause liver damage when consumed by terrestrial and aquatic organisms. This review proposes a novel mechanism to help explain the toxic effects following ingestion, which involves the gut, microbial community, and liver through the gut-liver axis.
Study Finds PFOSA Can Suppress Immune Function in Developing Zebrafish (Danio rerio)
The Stockholm Convention has labeled PFOS a “persistent organic pollutant” due to its long-enduring prevalence, negative toxicological effects, and ability to bioaccumulate in living things. Concerns about PFOSA have been raised due to its similarity to PFOS, its ability to metabolize into PFOS, and its persistent use today
Comprehensive Research on PFAS Exposomics and Risk Assessment
The Columbia Environmental Research Center (CERC) conducts cutting-edge research on per- and polyfluoroalkyl substances (PFAS) through the lens of the One Health Paradigm, emphasizing the interconnectedness of human, animal, and environmental health.
Fishing, Hunting and Subsistence Living Integrated Science Team
The Fishing, Hunting, and Subsistence Living Integrated Science Team focuses on contaminant and pathogen exposures in the environment that could impact the presence and vitality of fish and wildlife populations that drive commercial, recreational and subsistence activities such as hunting and fishing. If actual risks are identified this project will inform how to economically and effectively...
Toxic effects of carbamazepine to embryonically exposed zebrafish during early life stage development Toxic effects of carbamazepine to embryonically exposed zebrafish during early life stage development
Embryonic zebrafish (Danio rerio) were exposed to 0, 1, 5, 10, or 50 micrograms per liter carbamazepine (CBZ) from 2 hours post fertilization (hpf) through hatching, and then sampled at 48, 72, or 144 hpf. Larvae collected at 48, 72, and 144 hpf were assessed for transcriptomic profiles using RNA sequencing. Larvae collected at 72 and 144 hpf time points were assessed for histological...
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Effects of carbamazepine to visual function in early life stage fish Effects of carbamazepine to visual function in early life stage fish
The frequent detection of pharmaceuticals and personal care products (PPCPs) in the environment raises concern for aquatic systems. Carbamazepine (CBZ), an antiepileptic drug, is among the most detected PPCP globally, with concentrations in surface water exceeding those that induce toxicity to aquatic organisms. Non-targeted transcriptomic profiling was conducted in zebrafish (Danio...
Authors
Jason Tyler Magnuson, Holly J. Puglis, Jessica K. Leet, Adam H. Moody, Célio Freire Mariz, Thea M. Edwards, Daniela M. Pampanin
Amitriptyline and nortriptyline induce ocular toxicity in early life stage zebrafish (Danio rerio) Amitriptyline and nortriptyline induce ocular toxicity in early life stage zebrafish (Danio rerio)
The global use of antidepressants has steadily increased, raising concern to aquatic ecosystems due to the incomplete removal during wastewater treatment. Tricyclic antidepressants (TCAs) act on the neuronal system by inhibiting the reuptake of serotonin and norepinephrine. However, despite visual function being heavily dependent on the neuronal system, a knowledge gap remains regarding...
Authors
Marwin Jafari, Jason Tyler Magnuson, Fabian Essfeld, Sebastian Eilebrecht, Katharina Brotzmann, Daniela M. Pampanin
Perfluorodecanoic acid (PFDA) disrupts immune regulation via the toll-like receptor signaling pathway in zebrafish Perfluorodecanoic acid (PFDA) disrupts immune regulation via the toll-like receptor signaling pathway in zebrafish
As there are a growing number of per- and polyfluoroalkyl substances (PFAS) alternative substitutes applied globally, it remains paramount to characterize their potential health risks. Perfluorodecanoic acid (PFDA) is the most common alternative PFAS detected in the environment; however, its toxic effects and underlying mechanism of action to aquatic biota remains unclear. In this study...
Authors
Jiazhen Wang, Di Fang, Jason Tyler Magnuson, Bentuo Xu, Chunmiao Zheng, Liang Tang, Wenhui Qiu
Metabolomic profiling identifies the mitochondria as a target of pentachlorophenol toxicity in the blood clam (Tegillarca granosa) Metabolomic profiling identifies the mitochondria as a target of pentachlorophenol toxicity in the blood clam (Tegillarca granosa)
The pervasive presence of pentachlorophenol (PCP) in aquatic-benthic ecosystems poses a threat to organisms. However, the toxicological mechanisms of PCP in benthic organisms are limited. In this study, Tegillarca granosa, a representative bivalve species, was treated with environmentally relevant concentrations of PCP (1, 10, and 100 μg/kg) and positive control for 28 days via sediment...
Authors
Yuyao Jiang, Yujia Yan, Yanru Guan, Jason Tyler Magnuson, Zijie Ding, Qingqing Ke, Aoxue Wang, Kun Qiao, Shuying Li, Wenjun Gui, Daniel Schlenk
Ecotoxicological effects of crude oil to early life stage Danio rerio: A molecular, morphological and behavioral approach focused on swim bladder development Ecotoxicological effects of crude oil to early life stage Danio rerio: A molecular, morphological and behavioral approach focused on swim bladder development
Proper development and inflation of the swim bladder is essential for swimming and foraging behavior in fish. To characterize the effects of the Brazilian oil spill that occurred between 2019 and 2020 to early life stage fish, the expression of genes involved in swim bladder development were targeted, with biochemical assays, morphology, and behavior assessed. The swim bladder was...
Authors
Célio F. Mariz, Maria Karolaine de Melo Alves, Jason Tyler Magnuson, Italo Braga de Castro, Felix Augusto Silva de Andrade, Eliete Zanardi-Lamardo, Igor Dias Medeiros, Paulo S. Carvalho
Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish
Perfluorodecanesulfonate (PFDS), a long-chain polyfluoroalkyl substance (PFAS), is widely detected in aquatic environments and increasingly recognized for its environmental persistence and bioaccumulative potential; however, its immunotoxicity remains poorly understood in aquatic biota. In this study, early life stage zebrafish (Danio rerio) were exposed to environmentally relevant...
Authors
Chengwei Zhou, Wei Cheng, Rongrong Xuan, Xinyuan Kang, Jiazhen Wang, Jason Tyler Magnuson, Jialin Li, Di Fang, Wenhui Qiu
Non-USGS Publications**
Tang, L., Qiu, W., Zhang, S., Wang, J., Yang, X., Xu, B., Magnuson, J.T., Xu, E.G., Wu, M., and Zheng, C., 2023, Poly- and perfluoroalkyl substances induce immunotoxicity via the TLR pathway in zebrafish: Links to carbon-chain length: Environmental Science & Technology, v. 57, no. 15, p. 6139-6149. https://doi.org/10.1021/acs.est.2c09716
Magnuson, J.T., and Sandheinrich, M.B., 2023, Relation among mercury, selenium, and
biomarkers of oxidative stress in northern pike (Esox lucius): Toxics, v. 11, no. 3, p. 244.
https://www.mdpi.com/2305-6304/11/3/244
biomarkers of oxidative stress in northern pike (Esox lucius): Toxics, v. 11, no. 3, p. 244.
https://www.mdpi.com/2305-6304/11/3/244
Pampanin, D.M., Arnli, W.B., Magnuson, J.T., Monticelli, G., Dam, M., Mikalsen, S.-O., and Sydnes, M.O., 2023, Study of the long-finned pilot whale (Globicephala melas) bile content - An indicator of ocean health: Marine Pollution Bulletin, v. 189, p. 114795. https://doi.org/10.1016/j.marpolbul.2023.114795
Zhang, S., Zheng, M., Yang, G., Zhang, T., Magnuson, J.T., Chen, H., Zheng, C., and Qiu, W., 2023, Sunlight-mediated CaO2 inactivation of pathogen indicator organisms in surface water system: Roles of reactive species, characterization of pathogen inactivation: Water Research, v. 233, p. 119756. https://doi.org/10.1016/j.watres.2023.119756
Liu, S., Qiu, W., Li, R., Chen, B., Wu, X., Magnuson, J.T., Xu, B., Luo, S., Xu, E.G., and Zheng, C., 2023, Perfluorononanoic acid induces neurotoxicity via synaptogenesis signaling in zebrafish, v. 57, no. 9, p. 3783-3793. https://doi.org/10.1021/acs.est.2c06739
Magnuson, J.T., Fuller, N., McGruer, V., Huff Hartz, K.E., Acuña, S., Whitledge, G.W., Lydy, M.J., and Schlenk, D., 2023, Effect of temperature and dietary pesticide exposure on neuroendocrine and olfactory responses in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Pollution, v. 318, p. 120938. https://doi.org/10.1016/j.envpol.2022.120938
Chen, Q., Gao, Z., Wang, K., Magnuson, J.T., Chen, Y., Li, M., Shi, H., and Xu, L., 2023, High accumulation of microplastic fibers in fish hindgut induces an enhancement of triphenyl phosphate hydroxylation: Environmental Pollution, v. 317, p. 120804. https://doi.org/10.1016/j.envpol.2022.120804
Magnuson, J.T., Leads, R.R., McGruer, V., Qian, L., Tanabe, P., Roberts, A.P., and Schlenk, D., 2023, Transcriptomic profiling of miR-203a inhibitor and miR-34b-injected zebrafish (Danio rerio) validates oil-induced neurological, cardiovascular and eye toxicity response pathways: Aquatic Toxicology, v. 254, p. 106356. https://doi.org/10.1016/j.aquatox.2022.106356
Liu, X., Liu, S., Qiu, W., Magnuson, J.T., Liu, Z., Yang, G., Chen, H., Li, Y., Xu, X., and Zheng, C., 2022, Cardiotoxicity of PFOA, PFOS, and PFOSA in early life stage zebrafish: Molecular changes to behavioral-level response: Sustainable Horizons, v. 3, p. 100027. https://doi.org/10.1016/j.horiz.2022.100027
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., McGruer, V., Schlenk, D., and Lydy, M.J., 2022, Dietary exposure to environmentally relevant pesticide mixtures impairs swimming performance and lipid homeostatic gene expression in Juvenile Chinook salmon at elevated water temperatures: Environmental Pollution, v. 314, p. 120308. https://doi.org/10.1016/j.envpol.2022.120308
Magnuson, J.T., Longenecker-Wright, Z., Havranek, I., Monticelli, G., Brekken, H.K., Kallenborn, R., Schlenk, D., Sydnes, M.O., and Pampanin, D.M., 2022, Bioaccumulation potential of the tricyclic antidepressant amitriptyline in a marine Polychaete, Nereis virens: Science of The Total Environment, v. 851, p. 158193. https://doi.org/10.1016/j.scitotenv.2022.158193
Xuan, R., Qiu, W., Zhou, Y., Magnuson, J.T., Luo, S., Greer, J.B., Xu, B., Liu, J., Xu, E.G., Schlenk, D., and Zheng, C., 2022, Parental transfer of an antibiotic mixture induces cardiotoxicity in early life-stage zebrafish: A cross-generational study: Science of The Total Environment, v. 849, p. 157726. https://doi.org/10.1016/j.scitotenv.2022.157726
Magnuson, J.T., Caceres, L., Sy, N., Ji, C., Tanabe, P., Gan, J., Lydy, M.J., and Schlenk, D., 2022, The use of non-targeted lipidomics and histopathology to characterize the neurotoxicity of bifenthrin to juvenile rainbow trout (Oncorhynchus mykiss): Environmental Science & Technology, v. 56, no. 16, p. 11482-11492. https://doi.org/10.1021/acs.est.2c01542
Chen, H., Qiu, W., Yang, X., Chen, F., Chen, J., Tang, L., Zhong, H., Magnuson, J.T., Zheng, C., and Xu, E.G., 2022, Perfluorooctane sulfonamide (PFOSA) induces cardiotoxicity via aryl hydrocarbon receptor activation in zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8438-8448. https://doi.org/10.1021/acs.est.1c08875
Qiu, W., Liu, T., Liu, X., Chen, H., Luo, S., Chen, Q., Magnuson, J.T., Zheng, C., Xu, E.G., and Schlenk, D., 2022, Enrofloxacin Induces Intestinal Microbiota-Mediated Immunosuppression in Zebrafish: Environmental Science & Technology, v. 56, no. 12, p. 8428-8437. https://doi.org/10.1021/acs.est.1c08712
Leads, R.R., Magnuson, J.T., Lucero, J., Lund, A.K., Schlenk, D., Chavez, J.R., and Roberts, A.P., 2022, Transcriptomic responses and apoptosis in larval red drum (Sciaenops ocellatus) co-exposed to crude oil and ultraviolet (UV) radiation: Marine Pollution Bulletin, v. 179, p. 113684. https://doi.org/10.1016/j.marpolbul.2022.113684
Magnuson, J.T., Fuller, N., Huff Hartz, K.E., Anzalone, S., Whitledge, G.W., Acuña, S., Lydy, M.J., and Schlenk, D., 2022, Dietary exposure to bifenthrin and fipronil impacts swimming performance in juvenile Chinook salmon (Oncorhynchus tshawytscha): Environmental Science & Technology, v. 56, no. 8, p. 5071-5080. https://doi.org/10.1021/acs.est.1c06609
Xu, B., Qiu, W., Du, J., Wan, Z., Zhou, J.L., Chen, H., Liu, R., Magnuson, J.T., and Zheng, C., 2022, Translocation, bioaccumulation, and distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in plants: iScience, v. 25, no. 4, p. 104061. https://doi.org/10.1016/j.isci.2022.104061
Fuller, N., Anzalone, S.E., Huff Hartz, K.E., Whitledge, G.W., Acuña, S., Magnuson, J.T., Schlenk, D., and Lydy, M.J., 2022, Bioavailability of legacy and current-use pesticides in juvenile Chinook salmon habitat of the Sacramento River watershed: Importance of sediment characteristics and extraction techniques: Chemosphere, v. 298, p. 134174. https://doi.org/10.1016/j.chemosphere.2022.134174
Anzalone, S.E., Fuller, N.W., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Magnuson, J.T., Schlenk, D., Acuña, S., and Lydy, M.J., 2022, Pesticide residues in juvenile Chinook salmon and prey items of the Sacramento River watershed, California – A comparison of riverine and floodplain habitats: Environmental Pollution, v. 303, p. 119102.
https://doi.org/10.1016/j.envpol.2022.119102
https://doi.org/10.1016/j.envpol.2022.119102
Qiu, W., Chen, B., Tang, L., Zheng, C., Xu, B., Liu, Z., Magnuson, J.T., Zhang, S., Schlenk, D., Xu, E.G., and Xing, B., 2022, Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB: Environmental Science & Technology, v. 56, no. 7, p. 4251-4261. https://doi.org/10.1021/acs.est.1c07343
Magnuson, J.T., Qian, L., McGruer, V., Cheng, V., Volz, D.C., and Schlenk, D., 2022, Relationship between miR-203a inhibition and oil-induced toxicity in early life stage zebrafish (Danio rerio): Toxicology Reports, v. 9, p. 373-381. https://doi.org/10.1016/j.toxrep.2022.03.006
Qiu, W., Chen, H., Zhang, S., Xiong, Y., Zheng, M., Zhu, T., Park, M., Magnuson, J.T., Zheng, C., and El-Din, M.G., 2022, Remediation of surface water contaminated by pathogenic microorganisms using calcium peroxide: Matrix effect, micro-mechanisms and morphological-physiological changes: Water Research, v. 211, p. 118074. https://doi.org/10.1016/j.watres.2022.118074
McGruer, V., Khursigara, A.J., Magnuson, J.T., Esbaugh, A.J., Greer, J.B., and Schlenk, D., 2021, Exposure to Deepwater Horizon crude oil increases free cholesterol in larval red drum (Sciaenops ocellatus): Aquatic Toxicology, v. 241, p. 105988. https://doi.org/10.1016/j.aquatox.2021.105988
Fuller, N., Huff Hartz, K.E., Johanif, N., Magnuson, J.T., Robinson, E.K., Fulton, C.A., Poynton, H.C., Connon, R.E., and Lydy, M.J., 2021, Enhanced trophic transfer of chlorpyrifos from resistant Hyalella azteca to inland silversides (Menidia beryllina) and effects on acetylcholinesterase activity and swimming performance at varying temperatures: Environmental Pollution, v. 291, p. 118217. https://doi.org/10.1016/j.envpol.2021.118217
Greer, J.B., Magnuson, J.T., McGruer, V., Qian, L., Dasgupta, S., Volz, D.C., and Schlenk, D., 2021, miR133b Microinjection during Early Development Targets Transcripts of Cardiomyocyte Ion Channels and Induces Oil-like Cardiotoxicity in Zebrafish (Danio rerio) Embryos: Chemical Research in Toxicology, v. 34, no. 10, p. 2209-2215. https://doi.org/10.1021/acs.chemrestox.1c00238
Ajitha, V., Sarasan, M., Parvathi Sreevidya, C., Aswathy, C., Kachiprath, B., Mohandas, A., Singh, I.S.B., Hameed, A.S.S., Schlenk, D., Magnuson, J.T., and Puthumana, J., 2021, Cytotoxic impacts of treated electroplating industrial effluent and the comparative effect of their metal components (Zn, Hg, and Zn+Hg) on Danio rerio gill (DrG) cell line: Science of The Total Environment, v. 793, p. 148533. https://doi.org/10.1016/j.scitotenv.2021.148533
Ji, C., Tanabe, P., Shi, Q., Qian, L., McGruer, V., Magnuson, J.T., Wang, X., Gan, J., Gadepalli, R.S., Rimoldi, J., and Schlenk, D., 2021, Stage Dependent Enantioselective Metabolism of Bifenthrin in Embryos of Zebrafish (Danio rerio) and Japanese Medaka (Oryzias latipes): Environmental Science & Technology, v. 55, no. 13, p. 9087-9096. https://doi.org/10.1021/acs.est.1c01663
Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Lydy, M.J., and Schlenk, D., 2021, Transcriptomic and Histopathological Effects of Bifenthrin to the Brain of Juvenile Rainbow Trout (Oncorhynchus mykiss): Toxics, v. 9, no. 3, p. 48. https://doi.org/10.3390/toxics9030048
Harraka, G.T., Magnuson, J.T., Du, B., Wong, C.S., Maruya, K., and Schlenk, D., 2021, Evaluating the estrogenicity of an effluent-dominated river in California, USA: Comparisons of in vitro and in vivo bioassays: Science of The Total Environment, v. 758, p. 143965. https://doi.org/10.1016/j.scitotenv.2020.143965
Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., and Wang, C., 2021, Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems: Journal of Hazardous Materials, v. 404, p. 124083. https://doi.org/10.1016/j.jhazmat.2020.124083
Ji, C., Magnuson, J.T., Zhang, W., and Zhao, M., 2021, New insight into the enantioselective cytotoxicity of cypermethrin: imbalance between cell cycle and apoptosis: Journal of Hazardous Materials, v. 403, p. 123893. https://doi.org/10.1016/j.jhazmat.2020.123893
Fuller, N., Magnuson, J.T., Huff Hartz, K.E., Fulton, C.A., Whitledge, G.W., Acuña, S., Schlenk, D., and Lydy, M.J., 2021, Effects of dietary cypermethrin exposure on swimming performance and expression of lipid homeostatic genes in livers of juvenile Chinook salmon, Oncorhynchus tshawytscha: Ecotoxicology, v. 30, no. 2, p. 257-267. https://doi.org/10.1007/s10646-021-02352-2
Chen, Q., Santos, M.M.d., Tanabe, P., Harraka, G.T., Magnuson, J.T., McGruer, V., Qiu, W., Shi, H., Snyder, S.A., and Schlenk, D., 2021, Bioassay guided analysis coupled with non-target chemical screening in polyethylene plastic shopping bag fragments after exposure to simulated gastric juice of Fish: Journal of Hazardous Materials, v. 401, p. 123421. https://doi.org/10.1016/j.jhazmat.2020.123421
Magnuson, J.T., Cryder, Z., Andrzejczyk, N.E., Harraka, G., Wolf, D.C., Gan, J., and Schlenk, D., 2020, Metabolomic Profiles in the Brains of Juvenile Steelhead (Oncorhynchus mykiss) Following Bifenthrin Treatment: Environmental Science & Technology, v. 54, no. 19, p. 12245-12253. https://doi.org/10.1021/acs.est.0c04847
Magnuson, J.T., Stieglitz, J.D., Garza, S.A., Benetti, D.D., Grosell, M., and Roberts, A.P., 2020, Development of visual function in early life stage mahi-mahi (coryphaena hippurus): Marine and Freshwater Behaviour and Physiology, v. 53, no. 5-6, p. 203-214. https://doi.org/10.1080/10236244.2020.1804300
Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., and Schlenk, D., 2020, Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring: Journal of Hazardous Materials, v. 399, p. 123009. https://doi.org/10.1016/j.jhazmat.2020.123009
Magnuson, J.T., Giroux, M., Cryder, Z., Gan, J., and Schlenk, D., 2020, The use of non-targeted metabolomics to assess the toxicity of bifenthrin to juvenile Chinook salmon (Oncorhynchus tshawytscha): Aquatic Toxicology, v. 224, p. 105518. https://doi.org/10.1016/j.aquatox.2020.105518
Bridges, K.N., Magnuson, J.T., Curran, T.E., Barker, A., Roberts, A.P., and Venables, B.J., 2019, Alterations to the vision-associated transcriptome of zebrafish (Danio rerio) following developmental norethindrone exposure: Environmental Toxicology and Pharmacology, v. 69, p. 137-142. https://doi.org/10.1016/j.etap.2019.04.011
Perrichon, P., Stieglitz, J.D., Xu, E.G., Magnuson, J.T., Pasparakis, C., Mager, E.M., Wang, Y., Schlenk, D., Benetti, D.D., Roberts, A.P., Grosell, M., and Burggren, W.W., 2019, Mahi-mahi (Coryphaena hippurus) life development: morphological, physiological, behavioral and molecular phenotypes: Developmental Dynamics, v. 248, no. 5, p. 337-350. https://doi.org/10.1002/dvdy.27
Xu, E.G., Magnuson, J.T., Diamante, G., Mager, E., Pasparakis, C., Grosell, M., Roberts, A.P., and Schlenk, D., 2018, Changes in microRNA–mRNA Signatures Agree with Morphological, Physiological, and Behavioral Changes in Larval Mahi-Mahi Treated with Deepwater Horizon Oil: Environmental Science & Technology, v. 52, no. 22, p. 13501-13510. https://doi.org/10.1021/acs.est.8b04169
Magnuson, J.T., Khursigara, A.J., Allmon, E.B., Esbaugh, A.J., and Roberts, A.P., 2018, Effects of Deepwater Horizon crude oil on ocular development in two estuarine fish species, red drum (Sciaenops ocellatus) and sheepshead minnow (Cyprinodon variegatus): Ecotoxicology and Environmental Safety, v. 166, p. 186-191. https://doi.org/10.1016/j.ecoenv.2018.09.087
Nielsen, K.M., Zhang, Y., Curran, T.E., Magnuson, J.T., Venables, B.J., Durrer, K.E., Allen, M.S., and Roberts, A.P., 2018, Alterations to the Intestinal Microbiome and Metabolome of Pimephales promelas and Mus musculus Following Exposure to Dietary Methylmercury: Environmental Science & Technology, v. 52, no. 15, p. 8774-8784. https://doi.org/10.1021/acs.est.8b01150
Nielsen, K.M., Krasnec, M.O., Magnuson, J.T., Morris, J.M., Gielazyn, M.L., Chavez, J.R., and Roberts, A.P., 2018, Influence of variable ultraviolet radiation and oil exposure duration on survival of red drum (Sciaenops ocellatus) larvae: Environmental Toxicology and Chemistry, v. 37, no. 9, p. 2372-2379. https://doi.org/10.1002/etc.4183
Xu, E.G., Khursigara, A.J., Magnuson, J., Hazard, E.S., Hardiman, G., Esbaugh, A.J., Roberts, A.P., and Schlenk, D., 2017, Larval Red Drum (Sciaenops ocellatus) Sublethal Exposure to Weathered Deepwater Horizon Crude Oil: Developmental and Transcriptomic Consequences: Environmental Science & Technology, v. 51, no. 17, p. 10162-10172. https://doi.org/10.1021/acs.est.7b02037
Sweet, L.E., Magnuson, J., Garner, T.R., Alloy, M.M., Stieglitz, J.D., Benetti, D., Grosell, M., and Roberts, A.P., 2017, Exposure to ultraviolet radiation late in development increases the toxicity of oil to mahi-mahi (Coryphaena hippurus) embryos: Environmental Toxicology and Chemistry, v. 36, no. 6, p. 1592-1598. https://doi.org/10.1002/etc.3687
Magnuson, J.T., and Schlenk, D., 2023, Chapter 3.2.1 - Metabolism vs. metabolomics: Mechanisms of endocrine disruption, in Carnevali, O., and Hardiman, G., eds., Environmental Contaminants and Endocrine Health: Academic Press, p. 235-245.
https://doi.org/10.1016/B978-0-12-824464-7.00014-3
https://doi.org/10.1016/B978-0-12-824464-7.00014-3
**Disclaimer: The views expressed in Non-USGS publications are those of the author and do not represent the views of the USGS, Department of the Interior, or the U.S. Government.